Testing a gender-inclusive program for HIV prevention

Harnessing the Power of Technology to Develop a Population-based HIV Prevention Program for Trans Girls

NA · Center for Innovative Public Health Research · NCT06586151

This study is testing a new HIV prevention program that uses text messages to help trans girls and nonbinary youth aged 14-18 learn how to protect themselves from HIV.

Quick facts

PhaseNA
Study typeInterventional
Enrollment200 (estimated)
Ages14 Years to 18 Years
SexMale
SponsorCenter for Innovative Public Health Research (other)
Locations1 site (San Clemente, California)
Trial IDNCT06586151 on ClinicalTrials.gov

What this trial studies

This study evaluates a gender-inclusive HIV prevention program aimed at trans girls and nonbinary youth assigned male at birth. The intervention involves providing information through text messaging to promote HIV preventive behaviors among adolescents aged 14-18. If successful, the program could be scaled up quickly and cost-effectively to reach a larger population. Participants will engage with the program over a six-month period while providing feedback through online surveys.

Who should consider this trial

Good fit: Ideal candidates are adolescents aged 14-18 assigned male at birth who identify as transgender, non-binary, or gender fluid.

Not a fit: Patients who do not identify as non-cisgender or are outside the age range of 14-18 may not benefit from this study.

Why it matters

Potential benefit: If successful, this program could significantly improve HIV prevention behaviors among trans girls and nonbinary youth.

How similar studies have performed: Other studies have shown success with similar gender-inclusive health interventions, indicating potential for positive outcomes in this area.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. assigned male sex at birth and currently have a non-cisgender identity (e.g., transgender girl, non-binary, gender fluid, unsure);
2. aged 14-18 years and have not yet graduated high school;
3. English-speaking;
4. the sole user of a cell phone with an unlimited text messaging plan;
5. have access to the Internet to complete online surveys;
6. intend to have the same cell number for the next 6 months;
7. provide informed assent;
8. not have taken part in a previous #TranscendentHealth study activity or know someone who is in the study to increase the diversity of input from transgirls, and
9. agree to enroll over the phone with study staff.

Exclusion Criteria:

* None beyond not meeting inclusion criteria

Where this trial is running

San Clemente, California

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: HIV Prevention, HIV, Adolescence, mHealth

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.