Intervention to improve PrEP use among Black men who have sex with men
Official title: Intervention to Enhance Prep Persistence Among Men
Run by Brown University · NCT06872307 · Data updated 2026-11-12
This study is testing a new support program to help Black men who have sex with men start and stick with PrEP to prevent HIV.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Men only |
| Enrollment | 300 (estimated) |
| Sponsor | Brown University Academic / other |
| Locations | 3 sites (Atlanta, Georgia and 2 other locations) |
| Status | Recruiting |
| Started | October 1, 2024 |
| Main results expected | July 31, 2028 |
| Study ends | July 31, 2028 |
| Registry record updated | October 16, 2026 |
| Trial ID | NCT06872307 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are Black/African American men aged 18 and older who have had at least one male sex partner in the past year and are HIV-negative.
✕Probably not a fit
Patients who do not identify as Black/African American or who have taken PrEP within the last 30 days will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate a patient navigation intervention designed to enhance the initiation, adherence, and retention of pre-exposure prophylaxis (PrEP) among Black/African American men who have sex with men (B/AA MSM). The study addresses the significant barriers that this population faces in accessing and maintaining PrEP care, which is crucial for HIV prevention. Participants will be enrolled in a randomized controlled trial to assess the effectiveness of the RAMP-It-Up intervention, which builds on previous pilot studies that demonstrated its acceptability and preliminary effectiveness. The trial will involve collaboration with community health centers to ensure culturally congruent healthcare services are provided.
Why it matters
Potential benefit: If successful, this intervention could significantly improve PrEP uptake and retention in care among Black men who have sex with men, ultimately reducing HIV transmission rates in this high-risk population.
How similar studies have gone: Previous studies have shown promising results with similar patient navigation interventions aimed at improving PrEP outcomes among high-risk populations, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18 years and older * Assigned male sex at birth * Report at least one male sex partner in the past 12 months * Meet the CDC eligibility criteria for PrEP * Have not taken PrEP for at least 30 days * Are HIV-negative based on antibody testing at the time of enrollment * Understand and speak English * Able to provide informed consent * Agree to authorize study access to their EHR and pharmacy fill data. Eligible patients who are interested in participating will be consented and enrolled into the study. Exclusion Criteria: * Under the age of 18 * Assigned female sex at birth * Has not had a male sex partner in the past 12 months * Does not meet CDC eligibility criteria for PrEP * Has taken PrEP within the last 30 days * HIV-positive or inconclusive HIV status based on antibody testing at the time of enrollment * Does not understand or speak English * Unable to provide informed consent * Does not agree to authorize study access to their EHR and pharmacy fill data.
Where it's running
-
Emory University
Atlanta, Georgia, United States Recruiting -
University of Mississippi Medical Center
Jackson, Mississippi, United States Recruiting -
The Rhode Island Public Health Institute
Providence, Rhode Island, United States Recruiting
Study contacts
- Study coordinator: Dr. Amy Nunn, ScD
- Email: amy_nunn@brown.edu
- Phone: 401-863-6568
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.