Condition

PrEP clinical trials and research

• 10Clinical trials
• 336NIH research projects
• 4Countries

Newest PrEP clinical trials

All recruiting trials (10)

• Long-acting HIV PrEP and contraception PK study in AGYW

  This study tests how long-acting cabotegravir for PrEP interacts with hormonal contraception in young women.

  Recruiting University of Alabama at Birmingham · Bontleng, Gaborone · NCT07516548

• PrEP Linkage With Immediate Medications in the Emergency Department

  This study tests starting PrEP right in the Parkland Memorial Hospital ED and linking patients to ongoing PrEP care to see if it increases PrEP uptake in Dallas.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07462611

• Linking Youth to PrEP Services for HIV Prevention

  This project tests a community-based PrEP delivery plus a supportive mobile app to help teens and young adults steadily use PrEP.

  Recruiting at 4 sites Westat · San Francisco, California and 3 other locations · NCT07438041

• PrEP Optimization Through Enhanced Continuum Tracking (PrOTECT AL)

  This project will test a real-time PrEP care dashboard and implementation strategies at seven Alabama clinics to see if they increase PrEP coverage and equity among people at risk for HIV.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT07231640

• ICONA Prevention Program for People Using PrEP in Italy

  This program will follow HIV-negative adults in Italy who are starting or already using PrEP to see how well PrEP prevents HIV, how tolerable it is, and what helps or hinders people from staying on it.

  Recruiting at 18 sites Fondazione ICONA · Chieti, Abruzzo and 52 other locations · NCT07186244

• Bringing PrEP to a family planning clinic

  This study tests whether offering PrEP in a family planning clinic is acceptable to patients and feasible for providers in Rhode Island.

  Recruiting Women and Infants Hospital of Rhode Island · Providence, Rhode Island · NCT06930508

• Evaluating a PrEP implementation strategy for incarcerated individuals

  This study is testing a new way to help people in jail get access to PrEP and learn about HIV prevention to see if it can improve their health outcomes.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06919419

• Predicting STIs in people using HIV prevention medication in Spain

  This study is trying to see if a new way to predict sexually transmitted infections can help people using HIV prevention medication in Spain stay healthier.

  Recruiting at 26 sites Hospital Universitario de Valme · Almería and 25 other locations · NCT06860945

• Increasing HIV prevention access for Black women

  This study is testing a new way to help Black women in Baltimore start taking HIV prevention medication by providing support and resources to overcome challenges they face.

  Recruiting Johns Hopkins Bloomberg School of Public Health · Baltimore, Maryland · NCT06703060

• Using PrEP, Doing It for Ourselves (UPDOs)

  This project will test whether UPDOs, an online video and telehealth program paired with salon outreach, helps Black cisgender women in the southeastern US learn about and start using PrEP.

  Recruiting Duke University · Durham, North Carolina · NCT06638892

NIH-funded research (newest 40 of 336)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• mChoice: Boosting PrEP Use and Adherence for Black and Latino MSM with Tailored Training and Support

  A national study to help Black and Latino men who have sex with men start and stick with PrEP through culturally matched provider training and patient support.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11624204

• Harnessing male peer networks to boost HIV testing and PrEP use

  A large clinical trial in South Africa tests whether giving HIV self-test kits through male peer networks, with phone support, increases PrEP uptake among men.

  NIH research Stellenbosch University · Stellenbosch, SOUTH AFRICA · NIH-11621079

• Harnessing men's peer networks to boost HIV self-testing and PrEP use

  A large project in South Africa tests whether giving HIV self-test kits through men’s social networks, with phone support, can lead to more men starting PrEP and using HIV testing.

  NIH research Stellenbosch University · Stellenbosch, SOUTH AFRICA · NIH-11621078

• Participatory system dynamics to improve PrEP access in the Bronx

  A community-driven project in the Bronx will use system dynamics to identify practical ways to help people at risk for HIV start and stay on PrEP.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11593939

• TB PrEP: Bringing HIV prevention to households affected by TB in Uganda

  Aims to help people in households with TB in Uganda access HIV PrEP as part of a combined prevention approach.

  NIH research University of Washington · Seattle, United States · NIH-11590744

• CARES: A practical program to help adolescent girls and young women use PrEP in Africa

  A program called CARES helps young women in South Africa and Zimbabwe use different PrEP options better, with counseling, reminders, and options for support.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-11589304

• CARES: a help plan to support PrEP use for adolescent girls and young women in Africa and beyond

  A real-world plan to help young women stay on PrEP and reduce HIV risk by using counseling, biomarker feedback, and flexible support options.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-11589303

• Multi-level HIV prevention in Ghana through community pharmacies

  A multi-level program tests using community pharmacies in Ghana to boost HIV testing and PrEP uptake among men at high risk.

  NIH research University of Rochester · Rochester, United States · NIH-11587443

• How well SMS reminders help cisgender women in Kenya stay on HIV PrEP

  A small study tests how two-way text message reminders and conversations help pregnant and postpartum women in Kenya stick to HIV PrEP.

  NIH research University of Washington · Seattle, United States · NIH-11580109

• A brief alcohol support for PrEP users to boost HIV prevention

  A short, friendly program helps people starting or restarting PrEP in Vietnam drink less and stick with PrEP to stay protected.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11574743

• How choosing PrEP products could improve HIV protection for young women in Kenya

  This project looks at which HIV-prevention options young Kenyan women prefer and how choosing a product affects how well they stay protected.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11572510

• Effectiveness of PrEP product choice for HIV prevention among young Kenyan women seeking reproductive health services

  A study tests which PrEP options best help young Kenyan women stay protected against HIV when they access reproductive health services.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11572509

• Mobile health support to boost PrEP and contraception use among young women in Zambia

  A mobile health program helps female university students in Zambia learn about and access HIV prevention and contraception.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11570031

• A social norms program to help urban adolescent girls and young women use PrEP

  A small pilot in Africa will test whether shaping social norms within networks of out-of-school AGYW can help increase PrEP use and adherence to reduce HIV risk.

  NIH research American University · Washington, UNITED STATES · NIH-11538496

• AI-powered tools to help youth choose PrEP and stay engaged in HIV prevention

  A new NIH grant will test AI-assisted supports on a digital platform to help youths aged 13–24 learn about PrEP options, choose the right method, and access benefits.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11537032

• PEP/PrEP access via pharmacist-prescribing by community pharmacists

  A community-pharmacy-based program tests giving PrEP and PEP directly from pharmacists to improve HIV prevention in communities.

  NIH research Empowerx, INC. · Del Mar, UNITED STATES · NIH-11536938

• PrEP My Way: a patient-friendly plan to help young Kenyan women stick with PrEP

  A patient-centered trial tests a new PrEP delivery approach that supports young women in staying on PrEP and protecting themselves and their babies.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11534545

• PrEP My Way: a peer-supported, flexible PrEP plan for young women in Kenya

  A new approach helps young Kenyan women stick with PrEP by letting them choose how to take it and using peer support and easy self-testing and self-care tools.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11534544

• Healthy Families-PrEP: helping women in Uganda start and stay on PrEP during periconception, pregnancy, and postpartum

  A program in Uganda helps periconception, pregnant, and postpartum women use PrEP safely to prevent HIV, with support sessions and monitoring.

  NIH research Yale University · New Haven, United States · NIH-11533806

• Better information on women’s PrEP choices and outcomes in Malawi

  A study in Malawi aims to understand how women choose between oral and injectable PrEP and what happens when these options are rolled out in real-world settings.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11532084

• Peer-led PrEP delivery for youth in Brazil: a community-based randomized trial

  A youth-focused, community-based program tests whether trained young peers can help more adolescents get HIV PrEP in Brazil.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11528283

• Peer-led PrEP delivery for youth in Brazil: a youth-focused PrEP access trial

  This project tests whether trained youth peer workers can deliver PrEP in community settings to increase PrEP uptake among young people in Brazil.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11528255

• How PrEP Drugs Affect HIV Risk in Women and Reproductive Health

  This project looks at how PrEP medicines work for women, and whether they influence pregnancy-related processes in the uterus.

  NIH research University of Nevada Reno · Reno, United States · NIH-11528077

• Modernizing sequencing capacity at a veterinary diagnostic lab to help One Health and antimicrobial stewardship

  A veterinary diagnostic lab at North Dakota State University is upgrading its sequencing equipment to speed up and lower the cost of analyzing animal health samples, supporting One Health and antimicrobial stewardship efforts.

  NIH research North Dakota State University · Fargo, United States · NIH-11527612

• Safer PrEP dosing for pregnant women in sub‑Saharan Africa

  Seeing if higher daily doses of the HIV prevention pill FTC/TDF during pregnancy help women in sub‑Saharan Africa maintain stronger protection from HIV.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11512886

• PrEP use for Black cisgender women: making HIV prevention more accessible

  This project tests practical strategies to help Black cisgender women in six U.S. counties start and keep using HIV PrEP.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11500991

• Adaptation of a problem-solving approach to boost PrEP use during pregnancy in Zimbabwe

  A multi-level program is being adapted to help pregnant and postpartum women in Zimbabwe start and stick with HIV PrEP, with support from providers and communities.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11490517

• Nurse-led group program to boost PrEP use for women at risk of HIV

  A nurse-developed, three-session group program helps women in midwestern cities start and stay on PrEP to prevent HIV.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11485334

• CAB-LA PrEP for breastfeeding women after delivery in Botswana

  This study tests a long-acting HIV prevention shot for new mothers who are breastfeeding in Botswana to see if it prevents HIV safely and effectively.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11478445

• Healthy Families-PrEP: helping pregnant and new mothers in Uganda stay HIV-free

  A family-focused program in Uganda tests an approach to help women who are planning pregnancy or are pregnant or postpartum use PrEP to prevent HIV infection.

  NIH research Yale University · New Haven, United States · NIH-11473991

• STI testing added to PrEP programs to protect women from HIV

  Offering STI testing alongside routine risk screening to see if more women aged 15–39 start and keep using PrEP to prevent HIV.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11472894

• Combined effects of PrEP and HIV stigma on PrEP adherence in youth at risk for HIV

  A small, patient-friendly study will explore how stigma around PrEP and HIV affects whether at-risk youth stick with PrEP, using real data from teens and young adults.

  NIH research Florida State University · Tallahassee, United States · NIH-11470901

• Improving HIV PrEP delivery by providers in the U.S.

  A short-term grant to help doctors, nurses, and other health workers better identify people at risk and prescribe HIV PrEP, and to keep patients using it over time.

  NIH research University of Rochester · Rochester, United States · NIH-11470888

• Injectable HIV PrEP in maternity clinics to protect pregnant and postpartum women

  A doctor-scientist team is testing a twice-yearly injectable HIV prevention medicine for pregnant and postpartum women in high-risk areas to help keep them and their babies HIV-free.

  NIH research University of Washington · Seattle, United States · NIH-11470489

• Advancing PrEP Access for Women in Georgia

  A study to help more women in Georgia get PrEP for HIV prevention through better provider training and a woman-focused decision tool.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-11470465

• Barbershop-based approach to reduce HIV stigma and boost testing and PrEP among young Black men

  A community program partners with barbershops to reduce HIV stigma and help young Black men get tested for HIV and start PrEP.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11470341

• Integrating long-acting PrEP into street medicine for people who use drugs

  This project tests whether a long-acting HIV prevention shot (lenacapavir) can be feasibly and acceptably offered by street-based health teams to people who use drugs.

  NIH research University of Washington · Seattle, United States · NIH-11469899

• Pregnancy safety and infant outcomes with long-acting PrEP agents (CAB-LA and LEN) for HIV prevention

  This study follows pregnant and breastfeeding women using long-acting PrEP drugs to understand safety for moms and babies when these medicines are taken during pregnancy and after birth.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11468380

• Suubi4PrEP: Improving PrEP Access and Adherence for Adolescent Girls and Young Women

  A program to help adolescent girls and young women in the U.S. and globally access and stick with PrEP to prevent HIV.

  NIH research Washington University · Saint Louis, United States · NIH-11467599

• Suubi4PrEP: Improving PrEP Access and Adherence for Adolescent Girls and Young Women

  A study to help young women aged 15-24 in the US and abroad access and stick with PrEP to prevent HIV.

  NIH research Washington University · Saint Louis, United States · NIH-11467584

Related topics

Quick answers

How many PrEP clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (7 trials), Botswana (1 trial), Spain (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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