Home › Trials › NCT07467018
Clinical trial Recruiting at 1 site Observational Ages 18 and up

Bringing long-acting lenacapavir PrEP to people who are unstably housed in Los Angeles County

Official title: Mobile Vehicle-Based Delivery of Lenacapavir Pre-Exposure Prophylaxis in Los Angeles County (MOVE-LA)

Run by University of California, Los Angeles · NCT07467018 · Data updated 2026-11-12

This project will try giving long-acting injectable lenacapavir as HIV prevention from UCLA's mobile health vans to adults who are unhoused or facing housing instability in Los Angeles County.

More HIV Prevention trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorUniversity of California, Los Angeles
Academic / other
Locations1 site (Santa Monica, California)
StatusRecruiting
StartedApril 21, 2026
Main results expectedDecember 31, 2026
Study endsDecember 31, 2027
Registry record updatedApril 23, 2026
Trial IDNCT07467018 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (≥18) in Los Angeles County who are reached by UCLA HHC mobile vans, speak English or Spanish, are HIV-negative or of unknown status, are considered at risk for HIV, and can provide informed consent are ideal candidates.

Probably not a fit

People with known hypersensitivity to lenacapavir or its formulation, those judged unsuitable due to clinical or psychosocial conditions, individuals already on other PrEP who refuse to discontinue, or those below the protocol's BMI cutoff may not receive benefit from this program.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational implementation project partners with the UCLA Health Homeless Healthcare Collaborative mobile vans to offer point-of-care HIV testing and on-site lenacapavir (LEN) PrEP to unstably housed adults in community settings such as shelters, encampments, and transitional housing. Eligible participants are adults reached by the vans who are HIV-negative or of unknown status, speak English or Spanish, and are judged at risk for HIV by clinicians. The study will document uptake, continuation, and implementation outcomes using Andersen's behavioral model and Proctor et al.'s implementation outcome framework. Data collection focuses on barriers, facilitators, and real-world delivery metrics rather than a randomized efficacy comparison.

Why it matters

Potential benefit: If successful, this approach could increase access to long-acting PrEP and reduce new HIV infections among people who are unhoused in Los Angeles County.

How similar studies have gone: Other long-acting injectable PrEP approaches such as cabotegravir have reduced HIV incidence in clinical trials, and lenacapavir has promising early data, but mobile community delivery of LEN PrEP is relatively untested.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Being reached for mobile health services by a UCLA HHC mobile van
* ≥18 years of age
* Able to provide informed consent
* English or Spanish-speaking
* Willing and able to comply with study procedures
* HIV unknown or negative status and HIV negative based on rapid 4th generation Ag/Ab test on the day of enrollment
* At-risk for HIV, based on clinician assessment (based on CDC guidelines; includes any individual requesting PrEP, regardless of reported risk factors for HIV)
* Pregnant and breastfeeding women/people can be offered LEN with counseling about benefits and risks.

Exclusion Criteria:

* Any clinical or psychosocial condition or prior therapy that, in the opinion of the investigator, would make the participant unsuitable for the study or unable to take LEN PrEP
* Known hypersensitivity to the study drug, the metabolites, or formulation excipient
* BMI \<35 kg/m2 (77 pounds)
* On oral or other long-acting PrEP and unwilling to discontinue
* Already taking LEN for HIV prevention
* Known HIV diagnosis or positive 4th generation HIV Ab/Ag test (on day of enrollment) or subsequent lab-based confirmatory testing.

Where it's running

  • UCLA Health Homeless Healthcare Collaborative
    Santa Monica, California, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov ↗ Find more trials like this →
Browse more
HIV Prevention 282University of California Los Angeles 1874
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.