Condition

High Grade Glioma clinical trials and research

• 43Clinical trials
• 23NIH research projects
• 26Countries

Newest High Grade Glioma clinical trials

All recruiting trials (43)

• Taste of hope: testing NRG-103 safety and dosing for adults with high-grade glioma

  This early-phase trial tests whether NRG-103 is safe and tolerable in adults with recurrent or progressive high-grade glioma and looks for early signs it might help.

  Recruiting at 2 sites Phase 1 Neuregen Therapeutics Co., Ltd. · Shanghai and 2 other locations · NCT07710690

• Dual-target CAR-NK cell therapy for recurrent glioblastoma and high-grade glioma

  This phase 1 study will test whether injecting dual-target CAR-NK cells into the brain is safe and can help adults with recurrent or progressive glioblastoma or other high-grade gliomas.

  Recruiting Phase 1 Beijing Biotech · Shenzhen, Guangdong · NCT07480941

• Intratumoral DNX-2401 for High-Grade Pediatric Brain Tumors

  This study tests whether a single injection of DNX-2401 into a pediatric brain tumor can help shrink the tumor and extend survival in kids and young adults with recurrent or refractory high-grade brain tumors.

  Recruiting Phase 2 Clinica Universidad de Navarra, Universidad de Navarra · Utrecht and 1 other locations · NCT07424092

• LMP744 (an indenoisoquinolone) for people with recurrent glioblastoma

  This trial will test whether the drug LMP744 can shrink tumors or slow progression in adults whose glioblastoma has returned after prior treatment.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07416188

• Fluorescence-enhanced stereotactic biopsy needle for tumor and vessel detection

  This project will test a biopsy needle fitted with 5-ALA fluorescence, Raman spectroscopy, and ultrasound to see if it can identify tumor tissue and blood vessels in adults with high-grade glioma.

  Recruiting Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Milan · NCT07286903

• Fluorescent-labeled nivolumab (Nivo800) imaging for high-grade glioma surgery

  This trial tests whether a near-infrared fluorescent version of the immunotherapy drug nivolumab can be given before planned surgery to visualize drug distribution in adults with suspected high-grade glioma.

  Recruiting Early Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT07210632

• Using carbon ion radiotherapy to treat high-grade glioma

  This study is testing a new type of radiation therapy using carbon ions combined with regular radiation to see if it can help people with high-grade glioma live longer and have fewer side effects.

  Recruiting Gansu Wuwei Tumor Hospital · Wuwei, Gansu · NCT06831773

• XRD-0394 with radiation therapy for high-grade glioma

  This trial tests whether adding the experimental drug XRD-0394 to radiation (and for some patients to temozolomide) is safe and helpful for adults with newly diagnosed or recurrent high-grade glioma.

  Recruiting Early Phase 1 NYU Langone Health · New York, New York · NCT06829173

• Measuring fluorescence from surgical suction during glioma surgery

  This study is testing a new device that measures fluorescence from surgical suction during glioma surgery to see if it helps doctors remove more tumor tissue compared to what they can see with their regular tools.

  Recruiting Kuopio University Hospital · Kuopio, Kuopio · NCT06736470

• Combining MAPK inhibitors with anti-PD1 therapy for pediatric gliomas with BRAF alterations

  This study is testing if combining two cancer drugs with a new therapy can help children with certain types of brain tumors feel better and have more treatment options.

  Recruiting Phase 1/2 Ann & Robert H Lurie Children's Hospital of Chicago · Washington D.C., District of Columbia and 2 other locations · NCT06712875

• Combining Atovaquone with Radiation for Treating Children's Brain Tumors

  This study is testing if adding atovaquone to radiation therapy can help children with aggressive brain tumors feel better and improve their treatment outcomes.

  Recruiting at 2 sites Phase 1 Emory University · Atlanta, Georgia and 1 other locations · NCT06624371

• Entrectinib treatment for young children with specific CNS tumors

  This study is testing if a new treatment called entrectinib can help young children under 3 with certain brain tumors feel better and live longer.

  Recruiting at 6 sites Phase 2 St. Jude Children's Research Hospital · Memphis, Tennessee and 5 other locations · NCT06528691

• Investigating immune therapy for children and young adults with specific brain tumors

  This study is testing if a new immune therapy called nivolumab can help children and young adults with certain brain tumors avoid or delay radiation treatment.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT06519682

• Combination of DB107-RRV, DB107-FC, and radiation therapy for high grade glioma

  This study is testing a new combination of treatments for people with newly diagnosed high grade glioma to see if it helps them live longer without their cancer getting worse after surgery.

  Recruiting at 5 sites Phase 1/2 University of California, San Francisco · Los Angeles, California and 4 other locations · NCT06504381

• Evaluating TX103 CAR-T Cell Therapy for Advanced Brain Tumors

  This study is testing a new CAR-T cell therapy called TX103 to see if it can safely help people with advanced brain tumors that keep coming back or getting worse.

  Recruiting at 4 sites Phase 1 Tcelltech Inc. · Phoenix, Arizona and 3 other locations · NCT06482905

• Treatment for inoperable high-grade brain tumors

  This study is testing a new treatment that combines laser therapy and medications to see if it can help people with inoperable high-grade brain tumors.

  Recruiting Phase 1 University of Miami · Miami, Florida · NCT06428045

• Intranasal NEO100 for Pediatric Brain Tumors: Safety and Dosing

  We’re testing whether delivering NEO100 through the nose is safe and achievable at higher doses for children with certain brain tumors.

  Recruiting Phase 1 Neonc Technologies, Inc. · Orange, California · NCT06357377

• Lorlatinib for newly diagnosed high-grade glioma with ALK or ROS1 fusions

  This trial will test whether the oral medicine lorlatinib helps children and young adults (ages 1–21) with newly diagnosed high-grade gliomas that have ALK or ROS1 fusions, given alone, with chemotherapy, or after radiation.

  Recruiting at 2 sites Early Phase 1 Nationwide Children's Hospital · Aurora, Colorado and 17 other locations · NCT06333899

• Combination treatment for recurrent high-grade glioma using DB107-RRV and DB107-FC

  This study is testing a new combination treatment for adults with recurrent high-grade gliomas to see if it can shrink tumors and help control the disease better.

  Recruiting Phase 2 University of Miami · Miami, Florida · NCT06264388

• New target method for treating high-grade glioma patients

  This study tests a new way of targeting radiation treatment for patients with high-grade glioma to see if it helps them live longer without their cancer getting worse and reduces side effects compared to the standard method.

  Recruiting Zhujiang Hospital · Guangzhou · NCT06215495

• Treatment of high-grade glioma in young patients using olutasidenib and temozolomide

  This study is testing if a new combination of olutasidenib and temozolomide can help young patients with high-grade gliomas that have a specific mutation feel better after their radiotherapy.

  Recruiting at 8 sites Phase 2 Rigel Pharmaceuticals · Aurora, Colorado and 19 other locations · NCT06161974

• Comparing two surgical approaches for high-grade glioma patients

  This study is testing whether a more extensive surgical method for removing high-grade brain tumors helps patients live longer and feel better compared to a standard approach.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06118723

• Testing BDTX-1535 for patients with recurrent high-grade glioma and glioblastoma

  This study is testing a new drug called BDTX-1535 to see if it can help patients with recurrent high-grade glioma or newly diagnosed glioblastoma who have certain changes in the EGFR protein.

  Recruiting at 2 sites Early Phase 1 St. Joseph's Hospital and Medical Center, Phoenix · Chandler, Arizona and 1 other locations · NCT06072586

• Using Chlorophyllin to Treat Brain Damage from Radiation in Glioma Patients

  This study is testing if Chlorophyllin can help glioma patients with brain damage from radiation feel better and improve their quality of life.

  Recruiting Phase 2 Tata Memorial Centre · Mumbai, Maharashtra · NCT06016452

• Multi-dimensional MRI habitat mapping to predict key gene mutations and prognosis in high-grade gliomas

  This project will use advanced MRI habitat analysis to try to predict key tumor gene changes and likely outcomes for adults with high-grade gliomas.

  Recruiting RenJi Hospital · Shanghai, Select A State Or Province and 1 other locations · NCT06002711

• Using omental tissue to treat recurrent glioblastoma

  This study is testing whether using a piece of fat from the abdomen can help improve treatment for patients with recurrent glioblastoma by delivering medication and immune cells more effectively to the tumor site.

  Recruiting Northwell Health · New York, New York · NCT05979064

• Surgical technique to improve outcomes in glioblastoma patients

  This study is testing a new surgical method using special tissue flaps to see if it can help people with newly diagnosed glioblastoma live longer and have fewer problems after surgery.

  Recruiting Northwell Health · New York, New York · NCT05954858

• Combining ribociclib and everolimus for treating high-grade gliomas in young patients

  This study is testing if a combination of two drugs, ribociclib and everolimus, can help young patients with high-grade gliomas live longer and feel better after their initial treatment.

  Recruiting at 12 sites Phase 2 Nationwide Children's Hospital · Aurora, Colorado and 19 other locations · NCT05843253

• Genetic profiling for pediatric high-grade glioma treatment eligibility

  This study is testing if genetic testing of brain tumors in children and young adults with high-grade gliomas can help match them to the best treatment options.

  Recruiting at 13 sites Nationwide Children's Hospital · Aurora, Colorado and 21 other locations · NCT05839379

• New imaging approach for assessing high grade glioma after radiation therapy

  This study is testing a new imaging method to see if it can help doctors find active high grade glioma in kids and adults after they've had radiation therapy.

  Recruiting Early Phase 1 University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT05632562

• Recording brain activity during surgery for high-grade glioma

  This study is testing if recording brain activity during surgery for high-grade glioma tumors can help us understand how these tumors interact with brain cells to improve treatment options.

  Recruiting Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT05565118

• Using 18F-fluciclovine PET-MRI to assess high-grade gliomas in children

  This study is testing a special imaging technique to see if it can help doctors tell the difference between real tumor growth and changes after treatment in children with high-grade brain tumors.

  Recruiting Early Phase 1 Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT05553041

• CAR T-cell therapy for pediatric brain tumors

  This study is testing a new CAR T-cell therapy for kids and young adults with tough brain tumors to see if it can safely help them when other treatments have failed.

  Recruiting Phase 1 Bambino Gesù Hospital and Research Institute · Roma, Italy · NCT05298995

• Lutathera treatment for recurrent high-grade brain tumors

  This study is testing if Lutathera can safely help children and young adults with recurring high-grade brain tumors that show certain markers on scans.

  Recruiting at 2 sites Phase 1/2 Nationwide Children's Hospital · Aurora, Colorado and 3 other locations · NCT05278208

• Predicting brain function changes in high-grade glioma patients after radiation

  This study is trying to see if brain scans and blood tests can help predict how radiation treatment affects brain function and memory in patients with high-grade glioma.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT05212272

• PEP-CMV vaccine for treating pediatric brain tumors

  This study is testing a new vaccine for kids with certain types of brain tumors to see if it can help them feel better when used with a common chemotherapy drug.

  Recruiting at 10 sites Phase 2 Nationwide Children's Hospital · Aurora, Colorado and 12 other locations · NCT05096481

• Creating a living tissue bank from glioma tumors

  This study is trying to create mini versions of glioma tumors from patients to see how they behave and how different treatments might work better for people with glioma.

  Recruiting Maastricht Radiation Oncology · Maastricht, Limburg · NCT04865315

• Using Larotrectinib for Children with Newly Diagnosed High-Grade Glioma with NTRK Fusion

  This study is testing if a new drug called larotrectinib can help children with a specific type of brain cancer called high-grade glioma that has an NTRK fusion.

  Recruiting at 20 sites Early Phase 1 Nationwide Children's Hospital · Aurora, Colorado and 20 other locations · NCT04655404

• RNA-lipid particle vaccines for treating newly diagnosed brain tumors in children and adults

  This study is testing a new type of vaccine made from RNA to see if it can safely help adults and children with newly diagnosed brain tumors feel better after their treatment.

  Recruiting at 2 sites Phase 1 University of Florida · Washington D.C., District of Columbia and 1 other locations · NCT04573140

• Treatment of pediatric patients with advanced solid tumors using LAM561

  This study is testing a new treatment called LAM561 for children with advanced solid tumors to see if it's safe and how well it works.

  Recruiting at 3 sites Phase 1/2 Laminar Pharmaceuticals · Little Rock, Arkansas and 2 other locations · NCT04299191

• Locoregional injections of expanded natural killer cells for high grade glioma

  This study is testing if giving special immune cells directly to patients with tough brain tumors can be safe and help them feel better.

  Recruiting Phase 1 Nationwide Children's Hospital · Columbus, Ohio · NCT04254419

• C7R-GD2 CAR T cells for brain tumors expressing GD2

  This study is testing a new treatment using specially modified immune cells to see if they can help people with certain types of brain tumors that have a specific protein called GD2.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT04099797

• Access to continued treatment with dabrafenib and/or trametinib for eligible patients

  This study is for patients with melanoma, lung cancer, or other solid tumors who have been doing well on dabrafenib and/or trametinib and want to keep getting these treatments without a break.

  Recruiting at 5 sites Phase 4 Novartis · Scottsdale, Arizona and 36 other locations · NCT03340506

NIH-funded research (23)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Liquid biopsy for monitoring high-grade glioma using patient-specific DNA junctions

  A Mayo Clinic team tests a blood test that looks for unique tumor DNA pieces in glioblastoma patients to monitor disease without frequent scans.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11457457

• Canine and human high-grade gliomas: linking dog and human tumor biology to guide better treatments

  A study in dogs with high-grade glioma aims to reveal parallels to human brain tumors so that treatments looked promising in dogs might translate to people.

  NIH research University of California at Davis · Davis, United States · NIH-11449919

• Targeted study on a pediatric brain cancer subtype with specific gene mutations

  A study to understand why a rare form of high-grade brain cancer in young people develops and to find new treatment targets.

  NIH research University of Georgia · Athens, United States · NIH-11395631

• PEP-CMV vaccine with nivolumab for pediatric and adult high-grade brain tumors

  A phase 1/2 trial tests a CMV-targeted vaccine plus a PD-1 blocker for newly diagnosed and recurrent high-grade brain tumors in children and adults.

  NIH research Washington University · Saint Louis, United States · NIH-11312693

• Better MRI detection and classification of invasive high-grade brain tumors

  This project uses advanced MRI scans to spot and tell apart invasive types of high-grade brain tumors so doctors can find tumor cells that hide beyond standard scans.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11247530

• Finding weaknesses in G34‑mutant high‑grade brain tumors

  This project looks at how specific genetic changes in G34‑mutant high‑grade brain tumors that affect adolescents and young adults create weaknesses that could point to new treatments.

  NIH research University of Georgia · Athens, United States · NIH-11192254

• What drives aggressive childhood brainstem tumors (DIPG)

  Researchers are using mouse models that carry the same H3 K27M change found in most DIPG to find biological weak points that could lead to new treatments for children with these tumors.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11178019

• Peptide vaccine targeting CMV for children with high-grade glioma, DIPG, and recurrent medulloblastoma

  This vaccine trains the immune system to target a viral protein (CMV pp65) that is often found in certain pediatric brain tumors to help slow or shrink the tumor.

  NIH research Duke University · Durham, United States · NIH-11177623

• Mapping how brain tumors connect with neural circuits in mice

  This study is looking at how glioblastoma, a serious brain cancer, interacts with normal brain cells in mice to find out how these connections might affect tumor growth and brain function, with the hope of discovering new ways to treat this condition.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11159369

• Understanding ATRX Mutations in Childhood Brain Tumors

  This research aims to understand how a specific genetic change, called an ATRX mutation, affects the growth of aggressive brain tumors in children, hoping to discover new ways to treat them.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11127747

• Detecting and categorizing high-grade glioma brain tumors using MRI

  This study is looking to make it easier for doctors to spot and understand different types of aggressive brain tumors using advanced MRI scans, which could help them plan better treatments and improve outcomes for patients with high-grade gliomas.

  NIH research Arizona State University-Tempe Campus · Tempe, United States · NIH-11044555

• Understanding genetic factors in a type of childhood brain tumor

  This study is looking at how certain changes in proteins in the brain might cause aggressive brain tumors in kids, with the goal of finding new ways to treat these tumors better.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-11034113

• New treatment for aggressive brain tumors in children and adults

  This study is testing a new treatment for kids with tough brain tumors by using a special vaccine and a medicine that helps the immune system fight the cancer better, with the hope of helping them live longer and feel better.

  NIH research Washington University · Saint Louis, United States · NIH-11029506

• Investigating how Hp1bp3 affects tumor growth in high grade glioma

  This study is looking at a serious brain tumor called high grade glioma to find out how certain changes in the tumor's DNA might help it grow, and how a protein called Hp1bp3 could help stop that growth, with the hope of discovering new treatments for patients facing this tough condition.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10997119

• Creating a new treatment for a rare brain cancer in children.

  This study is testing a new treatment for kids with a tough brain tumor called DIPG, aiming to make it safer and more effective by understanding how radiation therapy interacts with the brain's immune system.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-10993127

• Testing a new drug combined with radiation for brain tumors

  This study is looking at a new drug called WSD0628 to see if it can help make radiation therapy work better for patients with recurrent high-grade gliomas, like glioblastoma, while keeping side effects low.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10929435

• Understanding the genetics of high-grade gliomas

  This study is looking at glioblastoma, a tough type of brain cancer, to find out how its genes affect how it grows and resists treatment, and it also wants to understand how this cancer is linked to epilepsy, which many patients experience.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10895583

• Understanding how tumor cells grow and survive in aggressive childhood brain tumors

  This study is looking at aggressive brain tumors in kids to understand the different types of cells in these tumors and how they help them grow, with the hope of finding better treatments to help children live longer.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10890190

• Exploring vulnerabilities in a specific type of brain tumor in children and young adults

  This study is looking at certain brain tumors in kids and young adults to understand how specific gene changes affect their growth, with the hope of finding new ways to treat these tumors better.

  NIH research University of Georgia · Athens, United States · NIH-10883096

• Investigating how ATRX mutations affect cell cycle regulation in pediatric high-grade glioma

  This study is looking at how certain changes in a gene called ATRX affect kids with a serious brain cancer called pediatric high-grade glioma, especially after they receive radiation treatment, to find new ways to help improve their care.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10873090

• Blocking PD-1 helps the immune system fight pediatric high-grade glioma

  This study is looking at how a new treatment that blocks a specific pathway can help kids with aggressive brain tumors by boosting their immune system to fight the cancer better.

  NIH research University of Florida · Gainesville, United States · NIH-10872264

• Training family members to care for patients with brain tumors

  This study is creating a hands-on training program to help family caregivers of patients with high-grade gliomas learn important skills for daily care, manage symptoms, and feel more confident in their role, all while practicing real-life situations they might face.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10693312

• New vaccine targeting a virus in pediatric brain tumors

  This study is testing a new vaccine that helps the immune system fight certain brain tumors in kids caused by a virus, aiming to keep healthy brain tissue safe while helping those with high-grade glioma, diffuse intrinsic pontine glioma, and recurrent medulloblastoma.

  NIH research Duke University · Durham, United States · NIH-10492522

Related topics

Quick answers

How many High Grade Glioma clinical trials are recruiting right now?

43, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 26 countries. The most sites are in United States (31 trials), Canada (7 trials), China (7 trials), Germany (7 trials), Netherlands (7 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 11, Early Phase 1: 7, Phase 2: 7, Phase 1/2: 5. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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