Investigating how ATRX mutations affect cell cycle regulation in pediatric high-grade glioma
Official title: The role of ATRX mutation in the epigenetic dysregulation of cell cycle in pediatric high-grade glioma
Funded at University of Michigan at Ann Arbor · NIH-10873090 · Data updated 2026-11-12
This study is looking at how certain changes in a gene called ATRX affect kids with a serious brain cancer called pediatric high-grade glioma, especially after they receive radiation treatment, to find new ways to help improve their care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $378,300 |
| NIH project number | 5R01NS119231-04 |
| Project ID | NIH-10873090 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with pediatric high-grade glioma, particularly those with ATRX mutations.
✕Less likely to help
Patients without ATRX mutations or those with other types of brain tumors may not benefit from this research.
What this research studies
This research focuses on understanding the role of ATRX mutations in pediatric high-grade glioma (pHGG), a severe form of brain cancer in children. The study aims to explore how these mutations disrupt normal cell cycle checkpoints, particularly after radiation treatment. By using advanced mouse models, researchers will investigate the epigenetic mechanisms behind this dysfunction and how it relates to other mutations commonly found in pHGG. The ultimate goal is to identify potential targeted therapies that could improve treatment outcomes for affected children.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that significantly improve survival rates for children with pediatric high-grade glioma.
How similar studies have gone: Previous research has shown promising results in understanding the role of ATRX mutations in cancer, but this specific approach to pediatric high-grade glioma is relatively novel.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Koschmann, Carl J — University of Michigan at Ann Arbor
- Study coordinator: Koschmann, Carl J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.