Condition

Diffuse Midline Glioma, H3 K27M-Mutant clinical trials and research

• 14Clinical trials
• 21Countries

Newest Diffuse Midline Glioma, H3 K27M-Mutant clinical trials

All recruiting trials (14)

• VRT106 plus radiotherapy in adults with DMG/DIPG

  This trial tests whether adding VRT106 to radiotherapy is safe and could help adults with DMG/DIPG.

  Recruiting Phase 2 Guangzhou Virotech Pharmaceutical Co., Ltd. · Guangzhou, Guangdong · NCT07589257

• Combining Atovaquone with Radiation for Treating Children's Brain Tumors

  This study is testing if adding atovaquone to radiation therapy can help children with aggressive brain tumors feel better and improve their treatment outcomes.

  Recruiting at 2 sites Phase 1 Emory University · Atlanta, Georgia and 1 other locations · NCT06624371

• Intranasal NEO100 for Pediatric Brain Tumors: Safety and Dosing

  We’re testing whether delivering NEO100 through the nose is safe and achievable at higher doses for children with certain brain tumors.

  Recruiting Phase 1 Neonc Technologies, Inc. · Orange, California · NCT06357377

• New immunotherapy for treating brain tumors in children and young adults

  This study is testing a new immunotherapy treatment for children and young adults with aggressive brain tumors to see if it can help their immune system fight the cancer better.

  Recruiting Phase 1 OX2 Therapeutics · Minneapolis, Minnesota · NCT06305910

• Treatment of high-grade glioma in young patients using olutasidenib and temozolomide

  This study is testing if a new combination of olutasidenib and temozolomide can help young patients with high-grade gliomas that have a specific mutation feel better after their radiotherapy.

  Recruiting at 8 sites Phase 2 Rigel Pharmaceuticals · Aurora, Colorado and 19 other locations · NCT06161974

• Combining ribociclib and everolimus for treating high-grade gliomas in young patients

  This study is testing if a combination of two drugs, ribociclib and everolimus, can help young patients with high-grade gliomas live longer and feel better after their initial treatment.

  Recruiting at 12 sites Phase 2 Nationwide Children's Hospital · Aurora, Colorado and 19 other locations · NCT05843253

• Genetic profiling for pediatric high-grade glioma treatment eligibility

  This study is testing if genetic testing of brain tumors in children and young adults with high-grade gliomas can help match them to the best treatment options.

  Recruiting at 13 sites Nationwide Children's Hospital · Aurora, Colorado and 21 other locations · NCT05839379

• Using focused ultrasound to enhance drug delivery for brain tumors in children

  This study is testing whether using focused ultrasound can help deliver more chemotherapy directly to brain tumors in children while reducing side effects.

  Recruiting Phase 1 Columbia University · New York, New York · NCT05762419

• CAR T cell therapy targeting GD2 for treating Diffuse Midline Glioma in children

  This study is testing a new treatment using modified immune cells to see if it can help children and young adults with Diffuse Midline Glioma feel better and fight their cancer.

  Recruiting Phase 1 University College, London · London · NCT05544526

• New treatment for Diffuse Intrinsic Pontine Glioma

  This study is testing if a new drug called ONC201 can help kids with Diffuse Intrinsic Pontine Glioma live longer without their cancer getting worse, compared to an existing treatment called everolimus.

  Recruiting at 53 sites Phase 3 Gustave Roussy, Cancer Campus, Grand Paris · Brussels and 55 other locations · NCT05476939

• Observational assessment of treatment outcomes for patients with primary brain tumors

  This study looks at how well treatments work for people with rare primary brain tumors using new classification guidelines to see if they help doctors group patients better.

  Recruiting at 42 sites European Organisation for Research and Treatment of Cancer - EORTC · Innsbruck and 41 other locations · NCT05259605

• Combination therapy for treating diffuse midline gliomas

  This study is testing a new combination of treatments for people with diffuse midline gliomas to see if it can help them live longer and feel better.

  Recruiting at 27 sites Phase 2 University of California, San Francisco · Birmingham, Alabama and 31 other locations · NCT05009992

• Combination immunotherapy for newly diagnosed DIPG and DMG

  This study is testing a new combination of a cancer vaccine and other treatments to see if it can help children with newly diagnosed DIPG and DMG fight their tumors better after finishing radiation therapy.

  Recruiting at 3 sites Phase 1 Ann & Robert H Lurie Children's Hospital of Chicago · Orange, California and 2 other locations · NCT04943848

• Registry for patients with Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma

  This study is creating a registry to collect information and tissue samples from patients with Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma to help improve how these tumors are diagnosed and treated.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT03101813

Related topics

Quick answers

How many Diffuse Midline Glioma, H3 K27M-Mutant clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (10 trials), United Kingdom (5 trials), Australia (4 trials), Germany (4 trials), New Zealand (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 6, Phase 2: 4, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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