Condition

Diffuse Intrinsic Pontine Glioma clinical trials and research

• 24Clinical trials
• 9NIH research projects
• 20Countries

Newest Diffuse Intrinsic Pontine Glioma clinical trials

All recruiting trials (24)

• BCB-276 CAR T therapy for DIPG in children and young adults

  This study tests BCB-276, a patient's own CAR T cells against DIPG, after standard radiation, to see if it is safe and can help extend survival.

  Recruiting at 3 sites Phase 2 BrainChild Bio, Inc · Los Angeles, California and 5 other locations · NCT07680439

• VRT106 plus radiotherapy in adults with DMG/DIPG

  This trial tests whether adding VRT106 to radiotherapy is safe and could help adults with DMG/DIPG.

  Recruiting Phase 2 Guangzhou Virotech Pharmaceutical Co., Ltd. · Guangzhou, Guangdong · NCT07589257

• Combining Atovaquone with Radiation for Treating Children's Brain Tumors

  This study is testing if adding atovaquone to radiation therapy can help children with aggressive brain tumors feel better and improve their treatment outcomes.

  Recruiting at 2 sites Phase 1 Emory University · Atlanta, Georgia and 1 other locations · NCT06624371

• Eflornithine (DFMO) plus AMXT 1501 for neuroblastoma, CNS tumors, and sarcomas

  This trial tests whether adding the oral drug AMXT 1501 to oral DFMO can help children and young adults (diagnosed by age 21) with relapsed or refractory neuroblastoma, ETMR, ATRT, Ewing sarcoma, osteosarcoma, or newly diagnosed DIPG.

  Recruiting at 14 sites Phase 1/2 Milton S. Hershey Medical Center · Birmingham, Alabama and 13 other locations · NCT06465199

• Lorlatinib for newly diagnosed high-grade glioma with ALK or ROS1 fusions

  This trial will test whether the oral medicine lorlatinib helps children and young adults (ages 1–21) with newly diagnosed high-grade gliomas that have ALK or ROS1 fusions, given alone, with chemotherapy, or after radiation.

  Recruiting at 2 sites Early Phase 1 Nationwide Children's Hospital · Aurora, Colorado and 17 other locations · NCT06333899

• Evaluating a new CAR T-cell therapy for children with DIPG

  This study is testing a new CAR T-cell therapy to see if it can help children with DIPG fight their tumors after standard treatments.

  Recruiting Phase 1 Chulalongkorn University · Bangkok, Pathumwan · NCT06221553

• Treatment of high-grade glioma in young patients using olutasidenib and temozolomide

  This study is testing if a new combination of olutasidenib and temozolomide can help young patients with high-grade gliomas that have a specific mutation feel better after their radiotherapy.

  Recruiting at 8 sites Phase 2 Rigel Pharmaceuticals · Aurora, Colorado and 19 other locations · NCT06161974

• Treatment for young patients with relapsed or refractory brain tumors

  This study is testing a new way to deliver cancer drugs directly to the brain tumors of young patients under 22 who have not responded to other treatments, to see if it helps them feel better.

  Recruiting Phase 1/2 University of Miami · Miami, Florida · NCT05956821

• Combining ribociclib and everolimus for treating high-grade gliomas in young patients

  This study is testing if a combination of two drugs, ribociclib and everolimus, can help young patients with high-grade gliomas live longer and feel better after their initial treatment.

  Recruiting at 12 sites Phase 2 Nationwide Children's Hospital · Aurora, Colorado and 19 other locations · NCT05843253

• Genetic profiling for pediatric high-grade glioma treatment eligibility

  This study is testing if genetic testing of brain tumors in children and young adults with high-grade gliomas can help match them to the best treatment options.

  Recruiting at 13 sites Nationwide Children's Hospital · Aurora, Colorado and 21 other locations · NCT05839379

• Using focused ultrasound to enhance drug delivery for brain tumors in children

  This study is testing whether using focused ultrasound can help deliver more chemotherapy directly to brain tumors in children while reducing side effects.

  Recruiting Phase 1 Columbia University · New York, New York · NCT05762419

• Using a virus to treat pediatric brain tumors

  This study is testing a new virus treatment for children with a tough brain tumor called DIPG to see if it is safe and how much of it can be given.

  Recruiting Phase 1 Capital Medical University · Beijing, Beijing Municipality · NCT05717712

• Using a virus to treat progressive pediatric brain tumors

  This study is testing a new virus treatment for children with a serious brain tumor called DIPG to see if it's safe to use after other treatments like surgery and chemotherapy.

  Recruiting Phase 1 Capital Medical University · Beijing, Beijing Municipality · NCT05717699

• New treatment for Diffuse Intrinsic Pontine Glioma

  This study is testing if a new drug called ONC201 can help kids with Diffuse Intrinsic Pontine Glioma live longer without their cancer getting worse, compared to an existing treatment called everolimus.

  Recruiting at 53 sites Phase 3 Gustave Roussy, Cancer Campus, Grand Paris · Brussels and 55 other locations · NCT05476939

• CAR T-cell therapy for pediatric brain tumors

  This study is testing a new CAR T-cell therapy for kids and young adults with tough brain tumors to see if it can safely help them when other treatments have failed.

  Recruiting Phase 1 Bambino Gesù Hospital and Research Institute · Roma, Italy · NCT05298995

• PEP-CMV vaccine for treating pediatric brain tumors

  This study is testing a new vaccine for kids with certain types of brain tumors to see if it can help them feel better when used with a common chemotherapy drug.

  Recruiting at 10 sites Phase 2 Nationwide Children's Hospital · Aurora, Colorado and 12 other locations · NCT05096481

• Combination therapy for treating diffuse midline gliomas

  This study is testing a new combination of treatments for people with diffuse midline gliomas to see if it can help them live longer and feel better.

  Recruiting at 27 sites Phase 2 University of California, San Francisco · Birmingham, Alabama and 31 other locations · NCT05009992

• Combination immunotherapy for newly diagnosed DIPG and DMG

  This study is testing a new combination of a cancer vaccine and other treatments to see if it can help children with newly diagnosed DIPG and DMG fight their tumors better after finishing radiation therapy.

  Recruiting at 3 sites Phase 1 Ann & Robert H Lurie Children's Hospital of Chicago · Orange, California and 2 other locations · NCT04943848

• Precision medicine and cell therapy for children with brain and neuroblastoma cancers

  This study is testing a new treatment that combines targeted therapy with immune cell therapy to see if it helps children with tough brain cancers like DIPG and neuroblastoma.

  Recruiting at 2 sites Phase 1 University of Florida · Gainesville, Florida and 2 other locations · NCT04837547

• Using Larotrectinib for Children with Newly Diagnosed High-Grade Glioma with NTRK Fusion

  This study is testing if a new drug called larotrectinib can help children with a specific type of brain cancer called high-grade glioma that has an NTRK fusion.

  Recruiting at 20 sites Early Phase 1 Nationwide Children's Hospital · Aurora, Colorado and 20 other locations · NCT04655404

• Locoregional immunotherapy using CAR T cells for pediatric brain tumors

  This study is testing a new treatment using specially modified immune cells to see if it can help children and young adults with certain types of brain tumors feel better.

  Recruiting Phase 1 Seattle Children's Hospital · Seattle, Washington · NCT04185038

• C7R-GD2 CAR T cells for brain tumors expressing GD2

  This study is testing a new treatment using specially modified immune cells to see if they can help people with certain types of brain tumors that have a specific protein called GD2.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT04099797

• Registry for patients with Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma

  This study is creating a registry to collect information and tissue samples from patients with Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma to help improve how these tumors are diagnosed and treated.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT03101813

• Collecting samples from children with brainstem tumors

  This study is trying to collect samples from children with brainstem tumors to see if they can find genetic clues that might help create better treatments for these tough cancers.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT01106794

NIH-funded research (9)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• B7-H3 CAR T cells after initial radiation for children and young adults with DIPG

  A new treatment approach uses B7-H3 CAR T cells after initial radiation to help children and young adults with diffuse intrinsic pontine glioma feel better and live longer.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11335575

• Targeting the ATIC enzyme in diffuse intrinsic pontine glioma (DIPG)

  Researchers are testing ways to block a metabolic enzyme called ATIC to try to slow or stop aggressive DIPG tumors in children.

  NIH research Emory University · Atlanta, United States · NIH-11233309

• Investigating a new treatment target for a deadly childhood brain cancer

  This study is looking at a new way to fight a tough brain cancer called DIPG in kids by targeting a specific molecule that might help the tumors grow, with hopes of finding better treatments to help these children.

  NIH research Emory University · Atlanta, United States · NIH-11191212

• Peptide vaccine targeting CMV for children with high-grade glioma, DIPG, and recurrent medulloblastoma

  This vaccine trains the immune system to target a viral protein (CMV pp65) that is often found in certain pediatric brain tumors to help slow or shrink the tumor.

  NIH research Duke University · Durham, United States · NIH-11177623

• Using targeted therapy to treat a deadly brain tumor in children

  This study is testing a new treatment for children with a tough brain tumor called DIPG, using special molecules to target a specific gene mutation in the tumor, with the hope of helping kids live longer and healthier lives.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11099689

• Using B7-H3 CAR T cells after radiation to treat a deadly brain tumor in children and young adults

  This study is testing a new treatment using special immune cells called B7-H3 CAR T cells for children and young adults with a tough brain tumor called DIPG, hoping to help them live longer after their initial radiation therapy.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11048809

• Targeting a specific mutation in brain tumors with RNA nanoparticles

  This study is testing a new treatment for kids with Diffuse Intrinsic Pontine Glioma (DIPG), a tough-to-treat brain tumor, by using special mRNA vaccines that help the immune system fight the cancer, and it hopes to eventually help children with this condition.

  NIH research University of Florida · Gainesville, United States · NIH-10951747

• Investigating how a specific mutation affects aggressive brain tumors in children

  This study is looking at how a specific gene change in aggressive brain tumors called DIPGs, which mostly affect kids, might influence how these tumors grow and respond to treatments, with the hope of finding new ways to help fight this tough condition.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10919797

• New vaccine targeting a virus in pediatric brain tumors

  This study is testing a new vaccine that helps the immune system fight certain brain tumors in kids caused by a virus, aiming to keep healthy brain tissue safe while helping those with high-grade glioma, diffuse intrinsic pontine glioma, and recurrent medulloblastoma.

  NIH research Duke University · Durham, United States · NIH-10492522

Related topics

Quick answers

How many Diffuse Intrinsic Pontine Glioma clinical trials are recruiting right now?

24, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (18 trials), Australia (6 trials), New Zealand (6 trials), Canada (5 trials), Germany (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 10, Phase 2: 6, Phase 1/2: 2, Early Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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