Condition

Glioblastoma Multiforme clinical trials and research

• 47Clinical trials
• 13NIH research projects
• 19Countries

Newest Glioblastoma Multiforme clinical trials

All recruiting trials (47)

• LMP744 (an indenoisoquinolone) for people with recurrent glioblastoma

  This trial will test whether the drug LMP744 can shrink tumors or slow progression in adults whose glioblastoma has returned after prior treatment.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07416188

• Adding ruxolitinib to standard radiation and temozolomide for newly diagnosed glioblastoma

  This trial will try whether adding the oral drug ruxolitinib to standard radiation and temozolomide helps adults newly diagnosed with glioblastoma.

  Recruiting at 2 sites Phase 2 Baptist Health South Florida · Miami, Florida and 1 other locations · NCT06991101

• Radiation plus tarlatamab for DLL3-expressing tumors

  This trial will test whether giving tarlatamab together with standard palliative or consolidative radiation is safe for adults with DLL3-expressing or DLL3-prevalent tumors such as melanoma, medullary thyroid cancer, sinonasal undifferentiated carcinoma, esthesioneuroblastoma, and bladder cancer.

  Recruiting at 3 sites Phase 1/2 University of Arizona · Gilbert, Arizona and 2 other locations · NCT06814496

• Using low-intensity magnetic therapy for newly diagnosed glioblastoma patients

  This study is testing whether a low-intensity magnetic therapy device can safely help people who have just been diagnosed with glioblastoma.

  Recruiting at 6 sites BioTex, Inc. · Stuttgart, Baden-Wurttemberg and 5 other locations · NCT06533163

• Evaluating Bevacizumab with Focused Ultrasound for Recurrent Glioblastoma

  This study is testing if adding focused ultrasound to the standard treatment of Bevacizumab can help people with recurrent glioblastoma feel better and live longer.

  Recruiting at 2 sites Phase 3 NaviFUS Corporation · Taipei and 1 other locations · NCT06496971

• Using FET-PET fused with MRI to better map and treat glioblastoma

  This will try using FET-PET combined with contrast MRI to better identify tumor tissue and guide surgery and treatment for adults with a single, newly diagnosed glioblastoma.

  Recruiting Copernicus Memorial Hospital · Lodz, Łódź Voivodeship · NCT06466031

• Neoadjuvant radiochemotherapy for glioblastoma treatment

  This study is testing a new combination of radiation and chemotherapy before surgery to see if it helps people with glioblastoma feel better and live longer compared to standard treatment.

  Recruiting Phase 1 Hospital San Carlos, Madrid · Madrid · NCT06418113

• Comparing two chemotherapy combinations for treating relapsed glioblastoma

  This study is testing two different chemotherapy combinations to see if they can help people with relapsed glioblastoma live longer and feel better.

  Recruiting Phase 2 Université de Sherbrooke · Sherbrooke, Quebec · NCT06356883

• Lorlatinib for newly diagnosed high-grade glioma with ALK or ROS1 fusions

  This trial will test whether the oral medicine lorlatinib helps children and young adults (ages 1–21) with newly diagnosed high-grade gliomas that have ALK or ROS1 fusions, given alone, with chemotherapy, or after radiation.

  Recruiting at 2 sites Early Phase 1 Nationwide Children's Hospital · Aurora, Colorado and 17 other locations · NCT06333899

• Comparing surgery and best treatment for recurrent glioblastoma

  This study is testing whether surgery or the best available treatment helps people with recurring glioblastoma feel better and live longer.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06283927

• Using NanoTherm therapy for recurrent glioblastoma multiforme

  This study is testing a new treatment called NanoTherm therapy for people with recurrent glioblastoma multiforme to see if it can help them live longer and feel better alongside standard treatments.

  Recruiting Poznan University of Medical Sciences · Poznan · NCT06271421

• Comparing palliative care and surgery for high-grade glioma patients

  This study is testing whether palliative care or surgery helps people with high-grade glioma live longer and feel better.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06146738

• Comparing tumor resection and biopsy for high-grade glioma patients

  This study is testing whether removing a brain tumor or just taking a small sample helps older patients with high-grade gliomas live longer and feel better afterward.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06146725

• Investigating a new imaging technique for measuring glycolysis in glioblastoma tumors

  This study is testing a new imaging method to see if it can help doctors measure how energy is used in glioblastoma tumors and find hidden cancer cells that are hard to see.

  Recruiting Phase 1/2 Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT06059690

• Using sonodynamic therapy for recurrent glioblastoma

  This study is testing a new treatment that uses sound waves and a special drug to see if it can safely help people with recurrent glioblastoma by destroying tumor cells while protecting healthy brain tissue.

  Recruiting Phase 1 University of Virginia · Charlottesville, Virginia · NCT06039709

• Using Chlorophyllin to Treat Brain Damage from Radiation in Glioma Patients

  This study is testing if Chlorophyllin can help glioma patients with brain damage from radiation feel better and improve their quality of life.

  Recruiting Phase 2 Tata Memorial Centre · Mumbai, Maharashtra · NCT06016452

• Using omental tissue to treat recurrent glioblastoma

  This study is testing whether using a piece of fat from the abdomen can help improve treatment for patients with recurrent glioblastoma by delivering medication and immune cells more effectively to the tumor site.

  Recruiting Northwell Health · New York, New York · NCT05979064

• Treatment for young patients with relapsed or refractory brain tumors

  This study is testing a new way to deliver cancer drugs directly to the brain tumors of young patients under 22 who have not responded to other treatments, to see if it helps them feel better.

  Recruiting Phase 1/2 University of Miami · Miami, Florida · NCT05956821

• Surgical technique to improve outcomes in glioblastoma patients

  This study is testing a new surgical method using special tissue flaps to see if it can help people with newly diagnosed glioblastoma live longer and have fewer problems after surgery.

  Recruiting Northwell Health · New York, New York · NCT05954858

• Combining eflornithine and temozolomide for newly diagnosed glioblastoma

  This study is testing a new combination of two medications, eflornithine and temozolomide, to find the best dose for people with newly diagnosed glioblastoma.

  Recruiting at 7 sites Phase 1 Orbus Therapeutics, Inc. · Birmingham, Alabama and 7 other locations · NCT05879367

• Using MRI and machine learning to guide brain surgery for glioblastoma

  This study is testing if a computer program can use MRI scans to help doctors better plan surgery for patients with glioblastoma by predicting how the tumors will respond to treatment.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT05864976

• Combining ribociclib and everolimus for treating high-grade gliomas in young patients

  This study is testing if a combination of two drugs, ribociclib and everolimus, can help young patients with high-grade gliomas live longer and feel better after their initial treatment.

  Recruiting at 12 sites Phase 2 Nationwide Children's Hospital · Aurora, Colorado and 19 other locations · NCT05843253

• Genetic profiling for pediatric high-grade glioma treatment eligibility

  This study is testing if genetic testing of brain tumors in children and young adults with high-grade gliomas can help match them to the best treatment options.

  Recruiting at 13 sites Nationwide Children's Hospital · Aurora, Colorado and 21 other locations · NCT05839379

• Evaluating BEY1107 with Temozolomide for recurrent glioblastoma

  This study is testing a new treatment called BEY1107 combined with Temozolomide to see if it can help adults with recurrent glioblastoma who haven't had success with standard therapies.

  Recruiting Phase 1 BeyondBio Inc. · Seoul · NCT05769660

• Collecting and preserving glioblastoma tissue during surgery for future research

  This study is collecting and saving glioblastoma tumor tissue and blood samples during surgery to help researchers learn more about the disease and find better treatments.

  Recruiting Baptist Health South Florida · Miami, Florida · NCT05756985

• Comparing a Ketogenic Diet to a Standard Anti-Cancer Diet for Glioblastoma Patients

  This study is testing if a Ketogenic Diet can help people with newly diagnosed glioblastoma live longer compared to a standard anti-cancer diet while they receive their usual treatment.

  Recruiting at 4 sites Phase 2 Cedars-Sinai Medical Center · Los Angeles, California and 4 other locations · NCT05708352

• Gene therapy combined with radiotherapy for brain tumors

  This study is testing a new gene therapy combined with targeted radiation to see if it can safely help people with recurrent high-grade brain tumors.

  Recruiting Phase 1 Henry Ford Health System · Detroit, Michigan · NCT05686798

• Assessing glioblastoma response during MR-guided radiation therapy

  This study is testing how well glioblastoma responds to radiation therapy by using weekly MRI scans to track changes in the tumor for 20 patients.

  Recruiting University of Zurich · Zurich, Canton of Zurich · NCT05565326

• MRI-based imaging to guide radiotherapy for glioblastoma

  Doctors are testing whether special MRI techniques can map tumor hypoxia in glioblastoma patients to see if higher radiation doses can be targeted to the most aggressive parts of the tumor.

  Recruiting University of Sydney · St Leonards, New South Wales and 1 other locations · NCT05500612

• Combining Atezolizumab with radiation therapy for brain tumors

  This study is testing if combining a cancer drug called Atezolizumab with radiation therapy can help people with newly diagnosed brain tumors feel better and improve their treatment results.

  Recruiting Early Phase 1 Stony Brook University · Stony Brook, New York · NCT05423210

• Using CAR-T cells to target B7-H3 in recurrent glioblastoma

  This study is testing a new CAR-T cell therapy that targets a specific protein in patients with recurrent glioblastoma to see if it's safe and how much can be given.

  Recruiting Phase 1 UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT05366179

• Evaluating the TheraSphere device for recurrent glioblastoma

  This study is testing a new device that delivers targeted radiation directly to tumors in patients with recurrent glioblastoma to see if it can improve treatment results and reduce side effects.

  Recruiting at 7 sites Phase 1 Boston Scientific Corporation · Birmingham, Alabama and 8 other locations · NCT05303467

• Noninvasive detection of glioblastoma using sonobiopsy

  This study is testing a new noninvasive method called sonobiopsy to see if it can help doctors better detect and understand glioblastoma in patients.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT05281731

• Infusion of Bevacizumab with Chemotherapy and Radiation for Newly Diagnosed Glioblastoma

  This study is testing if adding a special infusion of Bevacizumab to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma live longer and feel better.

  Recruiting Phase 3 Northwell Health · New York, New York · NCT05271240

• Combining Pembrolizumab with M032 for treating recurrent brain tumors

  This study is testing a new treatment that combines two therapies, Pembrolizumab and M032, to see if it can help people with recurring brain tumors like glioblastoma feel better when other treatments haven't worked.

  Recruiting Phase 1/2 University of Alabama at Birmingham · Birmingham, Alabama · NCT05084430

• Combining carmustine wafers with retifanlimab and radiation for glioblastoma treatment

  This study is testing if combining carmustine wafers with retifanlimab and radiation can help adults with newly diagnosed glioblastoma live longer and feel better after surgery.

  Recruiting Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT05083754

• Using stem cells and chemotherapy to treat brain tumors

  This study is testing a new treatment using stem cells and chemotherapy to see if it can help people with recently removed brain tumors feel better and improve their chances of recovery.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT05052957

• Pembrolizumab with focused stereotactic radiation before surgery for recurrent glioblastoma

  This trial will test whether giving pembrolizumab plus focused radiation before planned surgery is safe and helps adults with recurrent glioblastoma live longer.

  Recruiting Phase 1/2 Cedars-Sinai Medical Center · Los Angeles, California · NCT04977375

• Wearable fluorescence imaging for brain tumor surgery

  This study is testing a new wearable device that uses special light to help surgeons find brain tumors during surgery, comparing it to a traditional microscope to see if it works just as well.

  Recruiting University of Kentucky · Lexington, Kentucky · NCT04780009

• Comparing Tamoxifen and Etoposide for Glioblastoma Recurrence

  This study is testing whether tamoxifen or etoposide is more effective for people whose glioblastoma has come back after initial treatment.

  Recruiting Phase 2 AHS Cancer Control Alberta · Edmonton, Alberta · NCT04765098

• Using a virus therapy to treat recurrent cerebellar brain tumors in children

  This study is testing a new virus treatment for children with recurring brain tumors to see if it can help them get better when combined with a low dose of radiation.

  Recruiting at 3 sites Phase 1 M.D. Anderson Cancer Center · Birmingham, Alabama and 2 other locations · NCT03911388

• Comparing awake craniotomy and general anesthesia for glioblastoma surgery

  This study is testing whether having brain surgery while awake is safer and more effective than having it under general anesthesia for people with glioblastoma in important areas of the brain.

  Recruiting at 5 sites Erasmus Medical Center · Ghent and 4 other locations · NCT03861299

• Intraarterial carboplatin combined with radiotherapy for relapsing glioblastoma

  This study is testing if a new way of giving carboplatin along with radiation can help people with relapsing glioblastoma live longer and feel better.

  Recruiting Phase 1/2 Université de Sherbrooke · Sherbrooke, Quebec · NCT03672721

• Gene therapy and chemotherapy for recurrent glioblastoma

  This study is testing a new treatment combining gene therapy, a medication, and radiation with chemotherapy to see if it helps people with recurrent glioblastoma or anaplastic astrocytoma who haven't responded to other treatments.

  Recruiting Phase 1/2 The Methodist Hospital Research Institute · Houston, Texas · NCT03596086

• Treatment of advanced solid tumors with APL-101 for specific genetic mutations

  This study is testing a new oral medication called APL-101 to see if it helps people with advanced lung cancer and other solid tumors that have certain genetic changes, especially those who haven't had success with standard treatments.

  Recruiting at 32 sites Phase 2 Apollomics Inc. · Los Angeles, California and 34 other locations · NCT03175224

• Using targeted delivery of Bevacizumab for treating recurrent brain tumors

  This study is testing a new way to deliver the cancer drug Bevacizumab directly to the brain to see if it helps people with recurrent brain tumors live longer and feel better compared to the usual method of giving it through an IV.

  Recruiting Phase 1/2 Northwell Health · New York, New York · NCT01269853

• Collecting blood and urine samples from glioblastoma patients receiving radiation therapy

  This study is collecting blood and urine samples from glioblastoma patients receiving radiation therapy to see if certain markers can help predict if their cancer will come back.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00083512

NIH-funded research (13)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Role of a brain tumor RNA in glioblastoma where a unique lncRNA may drive cancer cells

  A small, focused NIH grant explores how a brain cancer–related RNA called LINC01896 might control the growth of glioblastoma stem cells and influence treatment resistance.

  NIH research University of New Haven · West Haven, United States · NIH-11516889

• Sonodynamic therapy for recurrent glioblastoma using MRI-guided focused ultrasound and ALA

  A new treatment combines a drug called 5-ALA with MRI-guided focused ultrasound to target recurrent glioblastoma tumors.

  NIH research Sonalasense INC · San Carlos, UNITED STATES · NIH-11408427

• Enhanced delivery of neural stem cells to brain cancer with a biodegradable gel and focused ultrasound

  A new treatment approach uses patient-friendly neural stem cells delivered over several months with a biodegradable gel and ultrasound to target glioblastoma.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11381120

• STAG2 mutations and 3D genome organization in glioblastoma

  A study in adults with glioblastoma examines how STAG2 gene mutations may change the 3D structure of DNA in tumor cells and drive cancer.

  NIH research Georgetown University · Washington, United States · NIH-11353893

• Long-lasting stem-cell delivery for glioblastoma using an injectable gel and focused ultrasound

  An injectable, biodegradable gel that slowly releases tumor‑killing neural stem cells, paired with focused ultrasound to allow non-surgical re-dosing, for people with glioblastoma.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11192852

• Understanding the STAG2 Gene in Brain Tumors

  This project aims to understand how changes in a specific gene called STAG2 contribute to the growth of glioblastoma, a common type of brain tumor.

  NIH research Georgetown University · Washington, United States · NIH-11146340

• Understanding how metabolic changes help glioblastoma resist radiation treatment

  This study is looking at how glioblastoma, a tough type of brain cancer, manages to survive radiation therapy, and it hopes to find new ways to make this treatment work better for patients like you.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11010050

• Improving treatment for aggressive brain cancer using innovative cell delivery methods

  This study is testing a new way to treat glioblastoma, a tough brain cancer, by using a special gel and sound waves to help deliver helpful stem cells directly to the tumor, which could lead to better results and fewer surgeries for patients.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10981700

• Investigating Dichloroacetate for treating aggressive brain tumors

  This study is looking at how well a treatment called dichloroacetate (DCA) works for people with glioblastoma, a tough type of brain tumor, to see if it can help improve their health and survival.

  NIH research University of Florida · Gainesville, United States · NIH-10919168

• QBS-72S for newly diagnosed glioblastoma with unmethylated MGMT promoter

  A new drug called QBS-72S is being given to people with newly diagnosed glioblastoma whose tumors lack MGMT promoter methylation.

  NIH research Quadriga Biosciences, INC. · Los Altos, UNITED STATES · NIH-10918037

• Investigating how STAG2 mutations affect genome organization in brain tumors.

  This study is looking at how changes in a specific gene called STAG2 might affect the way brain tumor cells are organized and behave, which could help us understand more about glioblastoma and how it grows.

  NIH research Georgetown University · Washington, United States · NIH-10911159

• Understanding how metabolic changes help glioblastoma resist radiation treatment

  This study is looking into why glioblastoma, a tough type of brain cancer, often doesn't respond well to radiation therapy, and it's for patients who want to understand how researchers are trying to find new ways to make this treatment work better for them.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10877054

• MRI-guided focused ultrasound with 5‑ALA for recurrent glioblastoma

  This project uses a non-invasive MRI-guided focused ultrasound together with the drug 5‑ALA as a possible treatment for people with recurrent glioblastoma.

  NIH research Sonalasense INC · Oakland, UNITED STATES · NIH-10813104

Related topics

Quick answers

How many Glioblastoma Multiforme clinical trials are recruiting right now?

47, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 19 countries. The most sites are in United States (34 trials), Canada (7 trials), Germany (7 trials), Netherlands (6 trials), Australia (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 9, Phase 1/2: 9, Phase 2: 8, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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