Condition
High Grade Glioma (III or IV) clinical trials and research
As of November 12, 2026, Find a Trial lists 5 High Grade Glioma (III or IV) clinical trials that are recruiting, at sites in 5 countries (most in Italy (1), Iran (1), United States (1)). By phase: Phase 2 (1), Early Phase 1 (1), Phase 3 (1), Phase 1 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 5Clinical trials
- 5Countries
Newest High Grade Glioma (III or IV) clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Taste of hope: testing NRG-103 safety and dosing for adults with high-grade glioma | Phase 1 | Shanghai and 2 other locations | Recruiting | Jul 17, 2026 |
| Fluorescence-enhanced stereotactic biopsy needle for tumor and vessel detection | — | Milan | Recruiting | Dec 16, 2025 |
| Fluorescent-labeled nivolumab (Nivo800) imaging for high-grade glioma surgery | Early Phase 1 | Nashville, Tennessee | Recruiting | Oct 7, 2025 |
| First-line bevacizumab versus dexamethasone for symptomatic cerebral radiation necrosis after radiation for high-grade glioma or brain metastases. | Phase 3 | Amsterdam and 5 other locations | Recruiting | Mar 21, 2025 |
| Injection of natural killer cells for treating gliomas | Phase 2 | Tehran | Recruiting | Nov 13, 2024 |
All recruiting trials (5)
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Taste of hope: testing NRG-103 safety and dosing for adults with high-grade glioma
This early-phase trial tests whether NRG-103 is safe and tolerable in adults with recurrent or progressive high-grade glioma and looks for early signs it might help.
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Fluorescence-enhanced stereotactic biopsy needle for tumor and vessel detection
This project will test a biopsy needle fitted with 5-ALA fluorescence, Raman spectroscopy, and ultrasound to see if it can identify tumor tissue and blood vessels in adults with high-grade glioma.
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Fluorescent-labeled nivolumab (Nivo800) imaging for high-grade glioma surgery
This trial tests whether a near-infrared fluorescent version of the immunotherapy drug nivolumab can be given before planned surgery to visualize drug distribution in adults with suspected high-grade glioma.
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First-line bevacizumab versus dexamethasone for symptomatic cerebral radiation necrosis after radiation for high-grade glioma or brain metastases.
This trial will test whether first-line bevacizumab or dexamethasone works better at reducing symptoms in adults with symptomatic cerebral radiation necrosis after radiation for high-grade glioma or brain metastases.
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Injection of natural killer cells for treating gliomas
This study is testing whether a new treatment using natural killer cells can help young patients with high-grade gliomas, like glioblastoma, fight their cancer better.
Related topics
Quick answers
How many High Grade Glioma (III or IV) clinical trials are recruiting right now?
5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 5 countries. The most sites are in Italy (1 trial), Iran (1 trial), United States (1 trial), Netherlands (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 1, Early Phase 1: 1, Phase 3: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.