Canine and human high-grade gliomas: linking dog and human tumor biology to guide better treatments
Official title: Correlating the clinical and molecular features of canine high-grade glioma for improved translation to human high-grade glioma
Funded at University of California at Davis · NIH-11449919 · Data updated 2026-11-12
A study in dogs with high-grade glioma aims to reveal parallels to human brain tumors so that treatments looked promising in dogs might translate to people.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | August 11, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $621,660 |
| NIH project number | 1R37CA309054-01A1 |
| Project ID | NIH-11449919 on NIH RePORTER |
Who could benefit from this research
✓Could help
Dogs diagnosed with high-grade glioma will be included to study tumor biology and progression, with potential implications for human patients.
✕Less likely to help
The study may not directly benefit individual dogs in all cases if no effective therapies are identified.
What this research studies
This project compares clinical disease progression and molecular features of naturally occurring canine high-grade glioma with human glioma biology to identify signals that predict treatment responses. Researchers will collect clinical data, tumor samples, and treatment outcomes from dogs and relate these to what is known in human tumors. By using dogs as a parallel translational model with spontaneous tumor development, the study seeks to improve how we interpret preclinical findings for humans. The goal is to bridge gaps between rodent models and human patients to advance more reliable therapeutic strategies.
Why it matters
Potential benefit: If successful, findings could sharpen the relevance of dog models to human glioma, improving the design and predictability of future human trials.
How similar studies have gone: Prior work supports using canine glioma as a translational model; this study seeks prospective correlations to strengthen that link.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Toedebusch, Christine M — University of California at Davis
- Study coordinator: Toedebusch, Christine M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.