Understanding genetic factors in a type of childhood brain tumor
Official title: Identifying a transcriptional core regulatory circuitry and other critical transcription factor dependencies in H3.3 G34R/V high-grade glioma
Funded at University of Tennessee Health Sci Ctr · NIH-11034113 · Data updated 2026-11-12
This study is looking at how certain changes in proteins in the brain might cause aggressive brain tumors in kids, with the goal of finding new ways to treat these tumors better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | April 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $54,278 |
| NIH project number | 5F30CA271570-04 |
| Project ID | NIH-11034113 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents diagnosed with high-grade gliomas, particularly those with H3.3 G34R/V mutations.
✕Less likely to help
Patients with low-grade gliomas or those without the specific H3.3 G34R/V mutations may not benefit from this research.
What this research studies
This research investigates the genetic and molecular mechanisms behind high-grade gliomas (HGGs) in children, particularly focusing on specific mutations in histone proteins that may drive tumor development. By analyzing how these mutations affect gene regulation in the brain, the research aims to uncover new therapeutic targets. The approach involves advanced techniques to study the transcriptional regulatory programs influenced by these mutations, which could lead to more effective treatments for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and potentially better survival rates for children with high-grade gliomas.
How similar studies have gone: Other research has shown promise in targeting genetic mutations in tumors, suggesting that this approach could yield significant insights and advancements in treatment.
Where this research is happening
-
University of Tennessee Health Sci Ctr
Memphis, United States Active
Researchers
- Principal investigator: Roach, Jordan Trent — University of Tennessee Health Sci Ctr
- Study coordinator: Roach, Jordan Trent
Related research
Other NIH-funded projects on the same topics.
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Liquid biopsy for monitoring high-grade glioma using patient-specific DNA junctions
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-
Canine and human high-grade gliomas: linking dog and human tumor biology to guide better treatments
A study in dogs with high-grade glioma aims to reveal parallels to human brain tumors so that treatments looked promising in dogs might translate to people.
-
Targeted study on a pediatric brain cancer subtype with specific gene mutations
A study to understand why a rare form of high-grade brain cancer in young people develops and to find new treatment targets.
-
PEP-CMV vaccine with nivolumab for pediatric and adult high-grade brain tumors
A phase 1/2 trial tests a CMV-targeted vaccine plus a PD-1 blocker for newly diagnosed and recurrent high-grade brain tumors in children and adults.
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Better MRI detection and classification of invasive high-grade brain tumors
This project uses advanced MRI scans to spot and tell apart invasive types of high-grade brain tumors so doctors can find tumor cells that hide beyond standard scans.
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Finding weaknesses in G34‑mutant high‑grade brain tumors
This project looks at how specific genetic changes in G34‑mutant high‑grade brain tumors that affect adolescents and young adults create weaknesses that could point to new treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.