Understanding genetic factors in a type of childhood brain tumor
Identifying a transcriptional core regulatory circuitry and other critical transcription factor dependencies in H3.3 G34R/V high-grade glioma
This study is looking at how certain changes in proteins in the brain might cause aggressive brain tumors in kids, with the goal of finding new ways to treat these tumors better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11034113 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular mechanisms behind high-grade gliomas (HGGs) in children, particularly focusing on specific mutations in histone proteins that may drive tumor development. By analyzing how these mutations affect gene regulation in the brain, the research aims to uncover new therapeutic targets. The approach involves advanced techniques to study the transcriptional regulatory programs influenced by these mutations, which could lead to more effective treatments for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents diagnosed with high-grade gliomas, particularly those with H3.3 G34R/V mutations.
Not a fit: Patients with low-grade gliomas or those without the specific H3.3 G34R/V mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and potentially better survival rates for children with high-grade gliomas.
How similar studies have performed: Other research has shown promise in targeting genetic mutations in tumors, suggesting that this approach could yield significant insights and advancements in treatment.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Roach, Jordan Trent — University of Tennessee Health Sci Ctr
- Study coordinator: Roach, Jordan Trent
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.