Understanding the genetics of high-grade gliomas
Official title: Functional Genomics of High Grade Glioma
Funded at Baylor College of Medicine · NIH-10895583 · Data updated 2026-11-12
This study is looking at glioblastoma, a tough type of brain cancer, to find out how its genes affect how it grows and resists treatment, and it also wants to understand how this cancer is linked to epilepsy, which many patients experience.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 2, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $152,274 |
| NIH project number | 5R50CA252125-05 |
| Project ID | NIH-10895583 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with high-grade gliomas, particularly glioblastoma, and those experiencing glioma-associated epilepsy.
✕Less likely to help
Patients with low-grade gliomas or other types of brain tumors may not benefit from this research.
What this research studies
This research investigates high-grade gliomas, particularly glioblastoma, which is a severe and often fatal brain cancer. By utilizing advanced genomic sequencing technologies, the study aims to uncover the underlying genetic factors that contribute to the disease's progression and treatment resistance. The researchers are developing innovative methods to analyze genetic information in a living model, allowing them to test multiple genetic factors simultaneously. Additionally, the research will explore the relationship between gliomas and epilepsy, a common complication in patients with this type of tumor.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve outcomes for patients with high-grade gliomas.
How similar studies have gone: Previous research utilizing genomic approaches in cancer has shown promise, indicating potential for success in this novel application.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Yu, Kwanha — Baylor College of Medicine
- Study coordinator: Yu, Kwanha
Related research
Other NIH-funded projects on the same topics.
-
Liquid biopsy for monitoring high-grade glioma using patient-specific DNA junctions
A Mayo Clinic team tests a blood test that looks for unique tumor DNA pieces in glioblastoma patients to monitor disease without frequent scans.
-
Canine and human high-grade gliomas: linking dog and human tumor biology to guide better treatments
A study in dogs with high-grade glioma aims to reveal parallels to human brain tumors so that treatments looked promising in dogs might translate to people.
-
Targeted study on a pediatric brain cancer subtype with specific gene mutations
A study to understand why a rare form of high-grade brain cancer in young people develops and to find new treatment targets.
-
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A phase 1/2 trial tests a CMV-targeted vaccine plus a PD-1 blocker for newly diagnosed and recurrent high-grade brain tumors in children and adults.
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This project uses advanced MRI scans to spot and tell apart invasive types of high-grade brain tumors so doctors can find tumor cells that hide beyond standard scans.
-
Finding weaknesses in G34‑mutant high‑grade brain tumors
This project looks at how specific genetic changes in G34‑mutant high‑grade brain tumors that affect adolescents and young adults create weaknesses that could point to new treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.