Condition
WHO Grade IV Glioma clinical trials and research
As of November 12, 2026, Find a Trial lists 4 WHO Grade IV Glioma clinical trials that are recruiting, at sites in 7 countries (most in Australia (4), Canada (4), Germany (4)). By phase: Phase 2 (2), Early Phase 1 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 4Clinical trials
- 7Countries
Newest WHO Grade IV Glioma clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Lorlatinib for newly diagnosed high-grade glioma with ALK or ROS1 fusions | Early Phase 1 | Aurora, Colorado and 17 other locations | Recruiting | Mar 27, 2024 |
| Treatment of high-grade glioma in young patients using olutasidenib and temozolomide | Phase 2 | Aurora, Colorado and 19 other locations | Recruiting | Dec 8, 2023 |
| Combining ribociclib and everolimus for treating high-grade gliomas in young patients | Phase 2 | Aurora, Colorado and 19 other locations | Recruiting | May 6, 2023 |
| Genetic profiling for pediatric high-grade glioma treatment eligibility | — | Aurora, Colorado and 21 other locations | Recruiting | May 3, 2023 |
All recruiting trials (4)
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Lorlatinib for newly diagnosed high-grade glioma with ALK or ROS1 fusions
This trial will test whether the oral medicine lorlatinib helps children and young adults (ages 1–21) with newly diagnosed high-grade gliomas that have ALK or ROS1 fusions, given alone, with chemotherapy, or after radiation.
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Treatment of high-grade glioma in young patients using olutasidenib and temozolomide
This study is testing if a new combination of olutasidenib and temozolomide can help young patients with high-grade gliomas that have a specific mutation feel better after their radiotherapy.
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Combining ribociclib and everolimus for treating high-grade gliomas in young patients
This study is testing if a combination of two drugs, ribociclib and everolimus, can help young patients with high-grade gliomas live longer and feel better after their initial treatment.
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Genetic profiling for pediatric high-grade glioma treatment eligibility
This study is testing if genetic testing of brain tumors in children and young adults with high-grade gliomas can help match them to the best treatment options.
Related topics
Quick answers
How many WHO Grade IV Glioma clinical trials are recruiting right now?
4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 7 countries. The most sites are in Australia (4 trials), Canada (4 trials), Germany (4 trials), New Zealand (4 trials), United States (4 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.