Blocking PD-1 helps the immune system fight pediatric high-grade glioma
Thymic PD-1 blockade mediates the anti-tumor immune response in pediatric high-grade glioma
This study is looking at how a new treatment that blocks a specific pathway can help kids with aggressive brain tumors by boosting their immune system to fight the cancer better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10872264 on NIH RePORTER |
What this research studies
This research investigates how blocking the PD-1 pathway can enhance the immune response against high-grade gliomas in children. It focuses on understanding the role of PD-1 in T cell development within the thymus, which is crucial for generating effective immune cells. By combining PD-1 inhibitors with hematopoietic stem cell therapy, the study aims to expand the pool of T cells that can target tumors. This approach could lead to new treatment strategies for pediatric patients suffering from aggressive brain tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients diagnosed with high-grade glioma who are seeking innovative treatment options.
Not a fit: Patients with low-grade gliomas or other types of cancers unrelated to high-grade glioma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapy options for children with high-grade gliomas, potentially improving survival rates.
How similar studies have performed: Other studies have shown promising results with PD-1 blockade in various cancers, suggesting that this approach may also be effective in pediatric high-grade glioma.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Francis, Connor Patrick — University of Florida
- Study coordinator: Francis, Connor Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.