Understanding how tumor cells grow and survive in aggressive childhood brain tumors
Official title: Investigation of tumor stem cell maintenance and cellular hierarchy in pediatric high-grade glioma
Funded at University of Colorado Denver · NIH-10890190 · Data updated 2026-11-12
This study is looking at aggressive brain tumors in kids to understand the different types of cells in these tumors and how they help them grow, with the hope of finding better treatments to help children live longer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $93,872 |
| NIH project number | 5K00CA274654-03 |
| Project ID | NIH-10890190 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with high-grade gliomas, particularly those with diffuse midline gliomas or hemispheric histone 3-wild type tumors.
✕Less likely to help
Patients with low-grade gliomas or other types of brain tumors may not benefit from this research.
What this research studies
This research focuses on pediatric high-grade gliomas, which are aggressive brain tumors in children. The study aims to identify the different types of cells within these tumors and how they contribute to tumor growth and survival. By using advanced techniques like single-cell RNA sequencing, researchers will analyze tumor samples to uncover the biological characteristics that drive these cancers. The ultimate goal is to find new therapeutic options that can improve survival rates for affected children.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for pediatric high-grade gliomas, potentially improving survival rates.
How similar studies have gone: While there have been numerous studies on pediatric brain tumors, this specific approach focusing on tumor stem cells and cellular hierarchy is relatively novel and untested.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Desisto, John a — University of Colorado Denver
- Study coordinator: Desisto, John a
Related research
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.