Condition

WHO Grade III Glioma clinical trials and research

• 8Clinical trials
• 9Countries

Newest WHO Grade III Glioma clinical trials

All recruiting trials (8)

• Lorlatinib for newly diagnosed high-grade glioma with ALK or ROS1 fusions

  This trial will test whether the oral medicine lorlatinib helps children and young adults (ages 1–21) with newly diagnosed high-grade gliomas that have ALK or ROS1 fusions, given alone, with chemotherapy, or after radiation.

  Recruiting at 2 sites Early Phase 1 Nationwide Children's Hospital · Aurora, Colorado and 17 other locations · NCT06333899

• Treatment of high-grade glioma in young patients using olutasidenib and temozolomide

  This study is testing if a new combination of olutasidenib and temozolomide can help young patients with high-grade gliomas that have a specific mutation feel better after their radiotherapy.

  Recruiting at 8 sites Phase 2 Rigel Pharmaceuticals · Aurora, Colorado and 19 other locations · NCT06161974

• Combining ribociclib and everolimus for treating high-grade gliomas in young patients

  This study is testing if a combination of two drugs, ribociclib and everolimus, can help young patients with high-grade gliomas live longer and feel better after their initial treatment.

  Recruiting at 12 sites Phase 2 Nationwide Children's Hospital · Aurora, Colorado and 19 other locations · NCT05843253

• Genetic profiling for pediatric high-grade glioma treatment eligibility

  This study is testing if genetic testing of brain tumors in children and young adults with high-grade gliomas can help match them to the best treatment options.

  Recruiting at 13 sites Nationwide Children's Hospital · Aurora, Colorado and 21 other locations · NCT05839379

• Combination therapy for treating diffuse midline gliomas

  This study is testing a new combination of treatments for people with diffuse midline gliomas to see if it can help them live longer and feel better.

  Recruiting at 27 sites Phase 2 University of California, San Francisco · Birmingham, Alabama and 31 other locations · NCT05009992

• Chemotherapy and radiation therapy for treating certain types of gliomas

  This study is testing if a combination of a chemotherapy drug and radiation therapy can help people with certain types of brain tumors live longer and feel better.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04623931

• Using advanced MRI techniques to evaluate lower grade gliomas

  This study is testing if advanced MRI techniques can help doctors better understand and track the growth of lower grade brain tumors in patients.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT04540107

• Customized video to reduce anxiety for brain tumor patients and caregivers during radiation treatment

  This study tests if a personalized video can help reduce anxiety for brain tumor patients and their caregivers during radiation treatment.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT04479696

Related topics

Quick answers

How many WHO Grade III Glioma clinical trials are recruiting right now?

8, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (8 trials), Australia (5 trials), New Zealand (5 trials), Canada (4 trials), Germany (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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