Investigating how Hp1bp3 affects tumor growth in high grade glioma
Official title: Hp1bp3 oversees chromatin remodeling to slow tumor growth in high grade glioma
Funded at Baylor College of Medicine · NIH-10997119 · Data updated 2026-11-12
This study is looking at a serious brain tumor called high grade glioma to find out how certain changes in the tumor's DNA might help it grow, and how a protein called Hp1bp3 could help stop that growth, with the hope of discovering new treatments for patients facing this tough condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 9, 2024 |
| Project end | July 8, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31CA295034-01 |
| Project ID | NIH-10997119 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with high grade glioma, particularly those with specific genetic mutations related to Hp1bp3.
✕Less likely to help
Patients with low grade gliomas or other types of brain tumors may not benefit from this research.
What this research studies
This research focuses on high grade glioma (HGG), a deadly brain tumor that has seen little improvement in treatment over the past 30 years. The study aims to understand the epigenetic changes that contribute to tumor growth and how the protein Hp1bp3 may act as a tumor suppressor. By using advanced techniques like ATAC sequencing, researchers will analyze chromatin accessibility in tumors to identify mechanisms that could slow tumor progression. The findings could lead to new therapeutic strategies for patients with HGG.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve survival rates for patients with high grade glioma.
How similar studies have gone: Previous research has shown promising results in targeting epigenetic modifications in cancer, suggesting that this approach could be effective.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Lozzi, Brittney — Baylor College of Medicine
- Study coordinator: Lozzi, Brittney
Related research
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-
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.