Condition

Anaplastic Astrocytoma clinical trials and research

• 11Clinical trials
• 1NIH research projects
• 7Countries

Newest Anaplastic Astrocytoma clinical trials

All recruiting trials (11)

• Lorlatinib for newly diagnosed high-grade glioma with ALK or ROS1 fusions

  This trial will test whether the oral medicine lorlatinib helps children and young adults (ages 1–21) with newly diagnosed high-grade gliomas that have ALK or ROS1 fusions, given alone, with chemotherapy, or after radiation.

  Recruiting at 2 sites Early Phase 1 Nationwide Children's Hospital · Aurora, Colorado and 17 other locations · NCT06333899

• Combination treatment for recurrent high-grade glioma using DB107-RRV and DB107-FC

  This study is testing a new combination treatment for adults with recurrent high-grade gliomas to see if it can shrink tumors and help control the disease better.

  Recruiting Phase 2 University of Miami · Miami, Florida · NCT06264388

• Treatment for young patients with relapsed or refractory brain tumors

  This study is testing a new way to deliver cancer drugs directly to the brain tumors of young patients under 22 who have not responded to other treatments, to see if it helps them feel better.

  Recruiting Phase 1/2 University of Miami · Miami, Florida · NCT05956821

• Combining ribociclib and everolimus for treating high-grade gliomas in young patients

  This study is testing if a combination of two drugs, ribociclib and everolimus, can help young patients with high-grade gliomas live longer and feel better after their initial treatment.

  Recruiting at 12 sites Phase 2 Nationwide Children's Hospital · Aurora, Colorado and 19 other locations · NCT05843253

• Genetic profiling for pediatric high-grade glioma treatment eligibility

  This study is testing if genetic testing of brain tumors in children and young adults with high-grade gliomas can help match them to the best treatment options.

  Recruiting at 13 sites Nationwide Children's Hospital · Aurora, Colorado and 21 other locations · NCT05839379

• Combining Temozolomide with Abexinostat for Recurrent Glioma Treatment

  This study is testing a new combination of two drugs, Temozolomide and Abexinostat, to see if it can help people with recurrent high-grade gliomas like glioblastoma feel better and manage their condition.

  Recruiting Phase 1 University of Nebraska · Omaha, Nebraska · NCT05698524

• Combining Pembrolizumab with M032 for treating recurrent brain tumors

  This study is testing a new treatment that combines two therapies, Pembrolizumab and M032, to see if it can help people with recurring brain tumors like glioblastoma feel better when other treatments haven't worked.

  Recruiting Phase 1/2 University of Alabama at Birmingham · Birmingham, Alabama · NCT05084430

• Wearable fluorescence imaging for brain tumor surgery

  This study is testing a new wearable device that uses special light to help surgeons find brain tumors during surgery, comparing it to a traditional microscope to see if it works just as well.

  Recruiting University of Kentucky · Lexington, Kentucky · NCT04780009

• Gene therapy combined with radiation and chemotherapy for newly diagnosed brain tumors

  This study is testing a new gene therapy combined with radiation and chemotherapy to see if it can help people who have just been diagnosed with aggressive brain tumors like glioblastoma or anaplastic astrocytoma.

  Recruiting Phase 1/2 The Methodist Hospital Research Institute · Houston, Texas · NCT03603405

• Targeting brain tumors with a specific drug infusion and re-irradiation

  This study is testing a new way to deliver a drug directly to brain tumors in patients with certain aggressive types of glioblastoma to see if it can improve treatment results.

  Recruiting Phase 2 Northwell Health · New York, New York · NCT02800486

• Using targeted delivery of Bevacizumab for treating recurrent brain tumors

  This study is testing a new way to deliver the cancer drug Bevacizumab directly to the brain to see if it helps people with recurrent brain tumors live longer and feel better compared to the usual method of giving it through an IV.

  Recruiting Phase 1/2 Northwell Health · New York, New York · NCT01269853

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Investigating a new treatment for recurrent brain tumors using a viral vector and a prodrug.

  This study is looking at a new treatment for people with tough brain tumors called glioblastoma or anaplastic astrocytoma, using a special combination of therapies to see if it can help them live longer and fight their tumors better.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-10888393

Related topics

Quick answers

How many Anaplastic Astrocytoma clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (11 trials), Australia (3 trials), Canada (3 trials), Germany (3 trials), New Zealand (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 4, Phase 2: 3, Phase 1: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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