Condition

Glioma, Malignant clinical trials and research

• 17Clinical trials
• 6Countries

Newest Glioma, Malignant clinical trials

All recruiting trials (17)

• LMP744 (an indenoisoquinolone) for people with recurrent glioblastoma

  This trial will test whether the drug LMP744 can shrink tumors or slow progression in adults whose glioblastoma has returned after prior treatment.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07416188

• C5252 injection for intracranial glioma

  A phase I/IIa study tests C5252 given into the brain to see if it is safe and whether it helps people with recurrent malignant glioma after standard therapies.

  Recruiting Phase 1/2 ImmVira Pharma Co. Ltd · Tianjin, Tianjin Municipality · NCT07243340

• Using 18F-TRX to image solid tumors

  This trial tests whether the 18F-TRX PET tracer can detect tumors in adults with advanced solid tumors such as high‑grade glioma, clear cell renal cell carcinoma, or metastatic castration‑resistant prostate cancer.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT06942104

• Testing TNG456 and Abemaciclib in Patients with Solid Tumors Lacking MTAP

  This study is testing a new drug called TNG456, alone and with another drug called abemaciclib, to see if it helps people with advanced solid tumors that have lost a specific gene called MTAP.

  Recruiting at 15 sites Phase 1/2 Tango Therapeutics, Inc. · Scottsdale, Arizona and 14 other locations · NCT06810544

• Testing DSP-0390 in patients with IDH-mutant gliomas

  This study is testing a new drug called DSP-0390 in patients with specific types of brain tumors to see if it helps kill more tumor cells during surgery.

  Recruiting Early Phase 1 Washington University School of Medicine · St Louis, Missouri · NCT06636162

• Cognitive rehabilitation program for patients with diffuse glioma

  This study is testing a new online brain training program to see if it can help people with diffuse glioma improve their memory and thinking skills after treatment.

  Recruiting Institut du Cancer de Montpellier - Val d'Aurelle · Montpellier, Hérault and 7 other locations · NCT06468176

• Proton pulsed reduced-dose-rate radiotherapy for recurrent high-grade glioma

  This trial tests whether a special proton radiation method called PRDR helps people whose fast-growing glioma has come back after prior radiation.

  Recruiting Baptist Health South Florida · Boca Raton, Florida and 1 other locations · NCT06397560

• Improving glioma surgery and quality of life through personalized motor rehabilitation

  This study is testing if personalized motor rehab before surgery can help people with lower-grade gliomas have better surgery results and improve their quality of life.

  Recruiting University of Milan · Milan, Lombardy · NCT06381726

• Monitoring blood levels of microRNAs in patients with grade 4 gliomas

  This study is trying to see if tracking certain microRNAs in the blood can help tell the difference between tumor recurrence and tissue damage in patients with grade 4 gliomas after surgery.

  Recruiting University Hospital, Caen · Caen · NCT06203496

• Using FET PET to Distinguish Tumor Progression from Pseudoprogression in High-Grade Glioma

  This study is testing if a special brain scan can help tell the difference between real tumor growth and false alarms in patients with high-grade gliomas after radiation therapy.

  Recruiting at 2 sites Phase 2 Singapore General Hospital · Singapore and 1 other locations · NCT06172595

• Using omental tissue to treat recurrent glioblastoma

  This study is testing whether using a piece of fat from the abdomen can help improve treatment for patients with recurrent glioblastoma by delivering medication and immune cells more effectively to the tumor site.

  Recruiting Northwell Health · New York, New York · NCT05979064

• Surgical technique to improve outcomes in glioblastoma patients

  This study is testing a new surgical method using special tissue flaps to see if it can help people with newly diagnosed glioblastoma live longer and have fewer problems after surgery.

  Recruiting Northwell Health · New York, New York · NCT05954858

• Evaluating a new imaging method for low-grade brain tumors in children

  This study is testing a new imaging method to see if it can help doctors better monitor and manage low-grade brain tumors in children.

  Recruiting Early Phase 1 Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT05555550

• Using 18F-fluciclovine PET-MRI to assess high-grade gliomas in children

  This study is testing a special imaging technique to see if it can help doctors tell the difference between real tumor growth and changes after treatment in children with high-grade brain tumors.

  Recruiting Early Phase 1 Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT05553041

• Using ultrasound and fluorescence to improve brain tumor removal

  This study is testing whether using ultrasound along with a special dye can help doctors remove brain tumors more completely in patients with certain types of brain cancer.

  Recruiting Sklifosovsky Institute of Emergency Care · Moscow · NCT05474573

• Infusion of Bevacizumab with Chemotherapy and Radiation for Newly Diagnosed Glioblastoma

  This study is testing if adding a special infusion of Bevacizumab to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma live longer and feel better.

  Recruiting Phase 3 Northwell Health · New York, New York · NCT05271240

• Combination treatment for recurrent malignant glioma

  This study is testing a new combination of treatments for patients with recurrent malignant glioma to see how safe they are and what the best dose is.

  Recruiting Phase 1 Duke University · Durham, North Carolina · NCT04547777

Related topics

Quick answers

How many Glioma, Malignant clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (11 trials), France (2 trials), Singapore (1 trial), Russia (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 3, Early Phase 1: 3, Phase 1: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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