Exploring vulnerabilities in a specific type of brain tumor in children and young adults
Official title: Developmental programs as vulnerabilities in H3.3G34-mutant high-grade glioma
Funded at University of Georgia · NIH-10883096 · Data updated 2026-11-12
This study is looking at certain brain tumors in kids and young adults to understand how specific gene changes affect their growth, with the hope of finding new ways to treat these tumors better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | September 12, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $358,901 |
| NIH project number | 1R01NS131659-01A1 |
| Project ID | NIH-10883096 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and young adults diagnosed with high-grade gliomas that exhibit H3.3G34 mutations.
✕Less likely to help
Patients with brain tumors that do not have the specific H3.3G34 mutations or those with other types of brain cancers may not benefit from this research.
What this research studies
This research investigates high-grade gliomas with specific mutations in the H3.3 histone variant, which primarily affect the cerebral hemispheres of children and young adults. The study aims to understand the cellular and molecular mechanisms behind these tumors, particularly focusing on the mutations in H3.3, ATRX, and TP53. By developing a human embryonic stem cell-based model, researchers will introduce these mutations to observe their effects on brain cell development and tumor formation. The goal is to identify new therapeutic targets that could lead to better treatment options for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for a currently untreatable subtype of brain tumors in children and young adults.
How similar studies have gone: While research on brain tumors is extensive, this specific approach using human embryonic stem cell models to study H3.3G34-mutant gliomas is relatively novel and has not been widely tested.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Funato, Kosuke — University of Georgia
- Study coordinator: Funato, Kosuke
Related research
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-
Targeted study on a pediatric brain cancer subtype with specific gene mutations
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-
Finding weaknesses in G34‑mutant high‑grade brain tumors
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.