Condition

Dysbiosis clinical trials and research

• 17Clinical trials
• 86NIH research projects
• 1New in 30 days
• 7Countries

Newest Dysbiosis clinical trials

All recruiting trials (17)

• Effect of Periodontal Therapy on Gut Microbes and Inflammation in People with Inflammatory Bowel Disease

  This study tests whether treating gum disease in people with inflammatory bowel disease can influence the gut microbiome and markers of systemic inflammation.

  Recruiting University of Turin, Italy · Turin, Turin · NCT07905859

• Metabolic and Functional Study of γδ T Cells in Critically Ill Patients

  Researchers will look at how γδ T cells behave in severely ill patients, including those with sepsis, to see how their metabolism and function change.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Outside of the US · NCT07680816

• Pulse-focused nutrition for school-age children

  This 6-week program tests whether a pulse-based diet (1.5 cups per week) improves gut health and metabolic markers in kids aged 6–13 who receive either pulses with education or pulses plus education and procurement support.

  Recruiting Florida State University · Tallahassee, Florida · NCT07648446

• Almonds, Gut Microbiome, and Kids

  This 8-week study tests whether a daily almond butter snack can favorably impact gut bacteria and metabolic health in children aged 6–13 compared with a chocolate spread control.

  Recruiting Florida State University · Tallahassee, Florida · NCT07636850

• Gut microbiome in gynecologic cancer patients with pelvic toxicity

  This study looks at whether gut bacteria profiles relate to pelvic toxicity after cancer treatment and how rectal ozone therapy might affect the gut microbiome and symptoms in women with gynecologic tumors.

  Recruiting at 2 sites Hospital Universitario de Gran Canaria Doctor Negrín · Las Palmas de Gran Canaria, Las Palmas and 1 other locations · NCT07259681

• How menstrual cups, tampons, and pads affect vaginal microbiota and immunity

  This project will see if using menstrual cups, tampons, or pads is linked to changes in vaginal bacteria, local immune responses, or recurrence of common vaginal infections in adult women.

  Recruiting Centre National de la Recherche Scientifique, France · Paris, Île-de-France Region · NCT07199998

• How medications that change gut bacteria affect immunotherapy in advanced non-small cell lung cancer

  This study tries to see if drugs that alter the gut microbiome change how well immunotherapy works in adults with stage III-C or IV non-small cell lung cancer.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07191171

• BioAmicus Complete for infants with colic, reflux, constipation, or loose stools (0–24 months)

  This study will see if the multistrain probiotic BioAmicus Complete can help reduce caregiver‑reported tummy symptoms in infants aged 0–24 months.

  Recruiting Haiphong University of Medicine and Pharmacy · Haiphong, Hai Phong · NCT07148583

• Impact of peanut butter on gut and metabolic health in children

  This study tests if eating smooth peanut butter every day can improve gut and metabolic health in children aged 6 to 13.

  Recruiting Florida State University · Tallahassee, Florida · NCT06916936

• Investigating how endocrine disruptors affect gut bacteria and colorectal cancer risk

  This study is trying to see if certain chemicals that mess with hormones can change gut bacteria and increase the risk of colorectal cancer in people.

  Recruiting Poitiers University Hospital · Poitiers · NCT06809660

• Effects of eating watermelon on gut and heart health

  This study is testing if eating fresh watermelon every day for six weeks can improve gut and heart health in young adults who are overweight or obese.

  Recruiting Florida State University · Tallahassee, Florida · NCT06588218

• Effects of California grapes on gut and heart health in overweight adults

  This study is testing whether eating freeze-dried grape powder can improve gut and heart health in overweight adults aged 45-70.

  Recruiting University of California, Davis · Davis, California · NCT06544954

• Fecal microbiota transplantation for treating axial spondyloarthritis

  This study is testing if a treatment using gut bacteria from healthy donors can help people with axial spondyloarthritis who aren't feeling better with their current medications.

  Recruiting Phase 2 University Hospital of North Norway · Tromsø · NCT06451588

• Reducing alcohol use in PrEP users through SBIRT intervention

  This study is testing if a program that helps people cut down on drinking can improve the health of those using PrEP for HIV prevention and help them stick to their medication.

  Recruiting University of Louisville · Louisville, Kentucky · NCT06005298

• Examining the gut microbiota in patients with anorexia nervosa

  This study looks at how the gut bacteria of people with anorexia nervosa differs from those who are healthy to see if these changes are linked to their symptoms and overall health.

  Recruiting Assistance Publique - Hôpitaux de Paris · Villejuif · NCT05632497

• Using probiotics to reduce heart disease risk in people with HIV who drink heavily

  This study is testing if a probiotic pill can help improve gut health and lower heart disease risk in people with HIV who drink heavily.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05288790

• Exploring the link between respiratory microbiome and severe asthma in young children

  This study is trying to see if the germs in the lungs of young children with severe asthma can help predict how well they respond to treatment.

  Recruiting University Hospital, Brest · Brest, Finistère · NCT05192499

NIH-funded research (newest 40 of 86)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Microbial Dysbiosis and Its Role in Pancreatic Cancer

  A doctor-researcher team at Northwestern University is studying how gut bacteria influence pancreatic cancer and its response to immunotherapy to find new ways to help patients.

  NIH research Northwestern University · Chicago, United States · NIH-11624054

• From Symbiosis to Dysbiosis: How Resolving Inflammation Could Restore Your Mouth’s Balance

  This grant explores how turning off the harmful inflammation in periodontitis and promoting natural healing could help restore the mouth’s healthy balance.

  NIH research Ada Forsyth Institute, INC. · Somerville, UNITED STATES · NIH-11621747

• Antibiotics, gut health, and skin reactions in kids

  A small study in children will look at whether antibiotic use and gut bacteria play a role in hives and related symptoms that children sometimes get after antibiotics.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11603169

• Novel therapeutic to protect the gut after radiation

  A new GI-directed treatment given after radiation exposure may reduce gut damage and improve survival in people exposed to high-dose radiation.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11572662

• A new GI-focused treatment to reduce radiation damage after exposure

  A potential GI-targeted therapy given after radiation exposure may help protect the gut and improve survival in people affected by radiation injuries.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11572658

• How a mouth bacterium might fuel gum disease and heart risk

  A small study will look at how a bacterium in the mouth that makes a reactive chemical (methylglyoxal) could drive gum inflammation and changes in the mouth’s bacteria, possibly linking to heart disease.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11564245

• Targeting gut microbes to restore food-tolerance in adults

  Aims to understand how gut bacteria and the lining of the gut interact to keep people with food allergies tolerant to what they eat.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11551491

• Antibiotics, Campylobacter, and Guillain-Barré Syndrome: Understanding Triggered Immunity

  A short, patient-friendly look at how certain antibiotics might unexpectedly raise the risk of Guillain-Barré syndrome in people exposed to Campylobacter bacteria.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11436090

• Biocontained whole-cell biosensors to detect dysbiosis and inflammation

  A scientist team is creating safe, engineered bacteria that can sit in saliva and signal early signs of imbalance in the microbiome and inflammation, potentially helping with early diagnosis.

  NIH research St. John's University · Queens, United States · NIH-11424406

• Vaginal estradiol vs moisturizer to help GSM symptoms and HIV-related changes in menopausal women with HIV

  This study tests whether vaginal estradiol or a moisturizer can ease menopause symptoms and improve vaginal health for women living with HIV.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11411827

• Alcohol, Gut Health, and PrEP: How a brief intervention might help HIV prevention care

  A program to help people using PrEP reduce risky drinking and improve gut health so they can stay on PrEP.

  NIH research University of Louisville · Louisville, United States · NIH-11396995

• Fecal microbiome therapy to help older adults recover after brain injury

  A trial explores giving a healthy gut microbiome to help people, especially older adults, recover better after a traumatic brain injury.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11383110

• Alcohol and HIV: Gut Imbalance Linked to Heart Disease

  A study at Brown University will look at how drinking alcohol in people with HIV changes gut bacteria and may raise the risk of heart problems and death.

  NIH research Brown University · Providence, United States · NIH-11382215

• Diabetes-related gut imbalance and heart disease in diabetes patients

  A study to understand how changes in gut bacteria caused by diabetes may raise the risk of heart disease and to explore ways to prevent it.

  NIH research Georgia State University · Atlanta, United States · NIH-11381740

• Gut-disease signals linked to HIV and heart disease

  This project will look at how gut bacteria and related molecules are connected to heart and blood vessel problems in people living with HIV.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11380801

• Modulating the peri-implant microbiome to prevent titanium-related inflammation

  This project looks at how a common oral bacteria, Veillonella parvula, helps protect other microbes around dental implants from oxidative stress and how this might affect inflammation and bone loss near implants.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11375062

• Antibiotics, the immune system, and gut health in kids with allergic reactions

  This grant explores how antibiotics and gut health may trigger itching rashes and other reactions in children, aiming to improve understanding and care for SSLR-like symptoms.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11374155

• Lung transplant patients: how lung bacteria may drive chronic rejection and how blocking IL-33 might help

  A scientist team at Baylor College of Medicine is studying whether imbalances in lung bacteria after transplant contribute to chronic rejection, and if blocking IL-33 could prevent this damage.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11364241

• Gut bacteria and increased inflammation after heart bypass in children with congenital heart defects

  This project will look at whether an unhealthy gut microbiome in children with congenital heart defects makes inflammation and gut barrier damage worse after cardiopulmonary bypass surgery.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11362104

• Exploring how multiple microbes interact to drive inflammatory mouth diseases

  A research project uses animal models to study how complex microbial communities in the mouth trigger and sustain inflammatory diseases.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11341069

• Why a baby’s gut matters: howearly bacteria may cause illness and how we can prevent it

  This grant looks at how early-life gut bacteria from group B strep can trigger infection and disease in newborns and what might stop it.

  NIH research University of Virginia · Charlottesville, United States · NIH-11340404

• Probiotic-loaded Hydrogels to Prevent and Treat Oral Candidiasis and Imbalance

  A probiotic-delivery hydrogel treatment using Lactobacillus paracasei 28.4 is being explored to prevent and treat oral yeast infections and microbial imbalance, especially in people with autoimmune or immunocompromised conditions.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-11338354

• Gut health and PTSD in veterans with inflammatory bowel disease

  A study explores how the gut microbiome and chronic stress from military experiences may influence inflammatory bowel disease in veterans.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11333100

• Targeting fluoride exporters to restore healthy mouth bacteria in young children

  Aims to help prevent early childhood caries by blocking fluoride-exporting proteins in harmful oral microbes to help shift dental biofilms toward health in children ages 0-11.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11332969

• How heavy drinking changes gut bacteria and harms heart and blood vessel health

  This work looks at whether hazardous alcohol use changes gut microbes and their chemicals in ways that worsen blood vessel and heart health for people who drink heavily.

  NIH research University of South Florida · Tampa, United States · NIH-11324502

• Understanding mouth bacteria linked to gum disease getting worse or staying stable

  This project looks at mouth bacteria over time in adults with chronic gum disease to find patterns that predict when the disease will worsen or remain stable.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11306656

• Modifying harmful oral microbes with smart peptides guided by machine learning

  A study aims to use machine learning to guide the design of targeted antimicrobial peptides that reshape the oral microbiome to help treat periodontitis in teens and adults.

  NIH research University of Kansas Lawrence · Lawrence, United States · NIH-11305025

• How gut bacterial indoles affect intestinal inflammation and healing

  This project looks at whether small molecules made by gut bacteria from dietary tryptophan, called indoles, help protect and heal the gut lining in people with Crohn's disease and ulcerative colitis.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11262908

• Gut‑targeted treatment to prevent severe radiation-related intestinal injury

  This project is developing a gut-targeted drug to help people who suffer high-dose radiation that damages the intestines.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11261072

• Dysbiosis, organ injury, and systemic inflammation in critical illness

  This grant explores how gut bacteria imbalances and organ injury contribute to widespread inflammation in critically ill patients, with the goal of finding therapies.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11257915

• How a Western high-fat diet can change the gut and raise heart disease risk

  This project looks at how a Western high-fat diet causes gut cell changes and bacterial shifts that may increase the chance of heart disease in adults.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11248757

• How succinate affects gut health and inflammation as we age

  This study is looking at how a substance called succinate, which is connected to aging, affects the gut bacteria and inflammation in both young and old mice, with the hope of finding new ways to improve health as we age.

  NIH research University of Virginia · Charlottesville, United States · NIH-11247689

• Understanding the role of gut bacteria in a serious intestinal condition in newborns.

  This study is looking into a serious condition called Hirschsprung-associated enterocolitis that affects babies with Hirschsprung Disease, and it aims to find out how certain bad bacteria in the gut might be causing problems, so we can create better treatments that tackle the issue at its source.

  NIH research University of Virginia · Charlottesville, United States · NIH-11239461

• Gut bacteria and tryptophan's role in lupus

  This project looks at how changes in gut bacteria and tryptophan metabolism may drive immune activity in people with systemic lupus.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11238996

• Restoring small-intestine bile acids to prevent antibiotic-related gut imbalance

  Researchers will try restoring how the small intestine handles bile acids to help protect gut bacteria in people taking antibiotics like amoxicillin.

  NIH research Brown University · Providence, United States · NIH-11229642

• How a mom’s inflammatory fats and lung microbes may raise a child’s allergy risk

  This project looks at whether higher levels of a type of inflammatory fat (called DHET) and changes in a mother's lung microbes increase a child's chance of developing allergies or asthma.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11225080

• Improving cell-based melanoma treatment affected by antibiotic-related gut imbalance

  Working to make cell-based immunotherapy work better for people with advanced melanoma whose gut bacteria were disrupted by antibiotics.

  NIH research Univ of Arkansas for Med Scis · Little Rock, United States · NIH-11211211

• How drinking changes gut bacteria and heart health in people with HIV

  This project looks at whether alcohol-related changes in gut bacteria in people with HIV lead to more inflammation and higher heart disease risk.

  NIH research Brown University · Providence, United States · NIH-11196102

• New ways to stop tooth decay in young children

  This project looks for new ways to stop tooth decay in young children by targeting specific germs in the mouth that cause cavities.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11192320

• Improving immune cell therapy for melanoma after antibiotic-related gut changes

  This work seeks ways to help cellular immunotherapy work better for people with melanoma whose gut bacteria have been disrupted by antibiotics.

  NIH research Univ of Arkansas for Med Scis · Little Rock, United States · NIH-11171417

Related topics

Quick answers

How many Dysbiosis clinical trials are recruiting right now?

17, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (7 trials), France (5 trials), Vietnam (1 trial), Italy (1 trial), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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