Antibiotics, the immune system, and gut health in kids with allergic reactions
Official title: Antibiotics, innate immunity, and dysbiosis in pediatric urticarial reactions
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11374155 · Data updated 2026-11-12
This grant explores how antibiotics and gut health may trigger itching rashes and other reactions in children, aiming to improve understanding and care for SSLR-like symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 17, 2025 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $401,250 |
| NIH project number | 5UG3AI190045-02 |
| Project ID | NIH-11374155 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 who experience antibiotic-associated reactions, including hives, facial swelling, fever, and joint symptoms, with non-diagnostic traditional allergy testing.
✕Less likely to help
Children without a history of antibiotic-associated reactions or who do not fit the study’s cohorts may not benefit from this research.
What this research studies
This project focuses on children aged 0-11 who experience antibiotic-associated skin and immune reactions. Using a multi-omics approach, researchers will examine blood inflammation markers, immune gene activity, gut bacteria, and metabolic changes to see how these factors relate to reactions like hives and joint pain. The study compares two groups of children to identify patterns that precede or accompany these reactions, especially when standard allergy tests are negative. The goal is to uncover non-traditional mechanisms behind these events and guide better prevention and treatment strategies for affected families.
Why it matters
Potential benefit: If successful, findings could lead to better prediction, prevention, and management of antibiotic-associated reactions in children, reducing distress and unnecessary allergy treatments.
How similar studies have gone: Previous work suggests complex, non-traditional pathways; this project proposes a novel, integrated multi-omics approach to clarify mechanisms.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Risma, Kimberly a — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Risma, Kimberly a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.