Exploring the link between respiratory microbiome and severe asthma in young children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the relationship between respiratory dysbiosis and severe asthma in preschool children under 3 years old. It aims to identify a microbiological signature that may predict corticosteroid resistance in these patients. The research employs a multicentric prospective case-control design, utilizing stool tests, blood tests, induced sputum, and nasal virology to gather data. The goal is to better understand how variations in the respiratory microbiome may influence asthma severity and treatment efficacy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age greater than 1 year and less than 3 years
* Diagnosis of asthma by a pediatrician
* Parental consent
* Affiliation to the social security system

Exclusion Criteria:

* Chronic pathologies: congenital heart disease, immune deficiency, cystic fibrosis, bronchopulmonary dysplasia, encephalopathy, primary ciliary dyskinesia, laryngomalacia, digestive pathology requiring digestive surgery
* Premature \< 34 SA
* Recent antibiotic therapy (\< 7 days)
* Treatment with oral corticosteroid therapy within the previous 10 days.
* Patient whose parent(s) is (are) minor(s)

Where it's running

• CHU de Brest
  Brest, Finistère, France Recruiting

Study contacts

• Study coordinator: Pierrick CROS
• Email: pierrick.cros@chu-brest.fr
• Phone: 02 98 22 36 59

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.