Diabetes-related gut imbalance and heart disease in diabetes patients
Official title: Role of Diabetes Associated Intestinal Dysbiosis in cardiac disease
Funded at Georgia State University · NIH-11381740 · Data updated 2026-11-12
A study to understand how changes in gut bacteria caused by diabetes may raise the risk of heart disease and to explore ways to prevent it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia State University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $521,855 |
| NIH project number | 5R01HL168465-04 |
| Project ID | NIH-11381740 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with diabetes who are at risk for or have heart disease may be most relevant for this research.
✕Less likely to help
Individuals without diabetes or heart disease may see less direct benefit from this study.
What this research studies
This project looks at how diabetes changes the gut microbiome and how those changes might lead to heart problems. Researchers will study microbial targets linked to inflammation and poorer heart function in diabetic conditions. They will also examine how diabetes-related shifts in gut bacteria, gut motility, and luminal glucose could worsen heart health. The team plans to test possible strategies to modify the microbiome to reduce heart disease risk in diabetes.
Why it matters
Potential benefit: If successful, the work could lead to new approaches to prevent heart disease in people with diabetes by targeting the gut microbiome.
How similar studies have gone: Previous animal studies showed that transferring microbiota from diabetic to non-diabetic mice affected heart function, suggesting potential for translation to humans.
Where this research is happening
-
Georgia State University
Atlanta, United States Active
Researchers
- Principal investigator: Zou, Jun — Georgia State University
- Study coordinator: Zou, Jun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.