Antibiotics, gut health, and skin reactions in kids
Official title: Antibiotics, innate immunity, and dysbiosis in pediatric urticarial reactions
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11603169 · Data updated 2026-11-12
A small study in children will look at whether antibiotic use and gut bacteria play a role in hives and related symptoms that children sometimes get after antibiotics.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 17, 2025 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $242,583 |
| NIH project number | 3UG3AI190045-02S1 |
| Project ID | NIH-11603169 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 who have experienced antibiotic-associated skin or joint reactions, including SSLR-like symptoms.
✕Less likely to help
Children without a history of antibiotic-related hypersensitivity or those outside the 0-11 age range.
What this research studies
This project focuses on 0-11 year olds who have antibiotic-related skin and joint reactions. Researchers will collect blood, stool, and immune data to explore inflammatory signals and gut microbes, aiming to see how antibiotics may disrupt the gut that leads to symptoms. They will compare two groups of children with these reactions to understand patterns and possible triggers. The study uses a multi-omics approach to connect clinical signs with biological changes in the body.
Why it matters
Potential benefit: If successful, findings could clarify why some kids have these reactions and point toward strategies to prevent or treat them.
How similar studies have gone: Prior studies have shown links between antibiotics, gut microbiota, and immune reactions, but this project expands to pediatric SSLR with a multi-omics view.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Risma, Kimberly a — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Risma, Kimberly a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.