Understanding the role of gut bacteria in a serious intestinal condition in newborns.
Official title: Dysbiosis in Hirschsprung Associated Enterocolitis Pathogenesis
Funded at University of Virginia · NIH-11239461 · Data updated 2026-11-12
This study is looking into a serious condition called Hirschsprung-associated enterocolitis that affects babies with Hirschsprung Disease, and it aims to find out how certain bad bacteria in the gut might be causing problems, so we can create better treatments that tackle the issue at its source.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | April 1, 2020 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $207,778 |
| NIH project number | 7R01DK125047-06 |
| Project ID | NIH-11239461 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants diagnosed with Hirschsprung Disease who are at risk of developing Hirschsprung-associated enterocolitis.
✕Less likely to help
Patients without Hirschsprung Disease or those who do not develop enterocolitis may not benefit from this research.
What this research studies
This research investigates Hirschsprung-associated enterocolitis (HAEC), a severe complication affecting infants with Hirschsprung Disease. The study aims to uncover the underlying mechanisms of HAEC, focusing on how imbalances in gut bacteria may contribute to the condition. By identifying specific harmful bacteria and understanding their interactions with the immune system, the research seeks to develop targeted therapies that go beyond current symptom management. This could lead to improved treatment strategies that address the root causes of HAEC.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the risk of life-threatening complications in infants with Hirschsprung Disease.
How similar studies have gone: Other research has shown promising results in understanding the role of gut microbiota in various gastrointestinal conditions, suggesting potential for success in this area as well.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Gosain, Ankush — University of Virginia
- Study coordinator: Gosain, Ankush
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.