Dysbiosis, organ injury, and systemic inflammation in critical illness
Official title: Dysbiosis, organ injury, and Systemic Inflammation
Funded at University of Illinois at Chicago · NIH-11257915 · Data updated 2026-11-12
This grant explores how gut bacteria imbalances and organ injury contribute to widespread inflammation in critically ill patients, with the goal of finding therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | June 1, 2026 |
| Project end | March 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $440,908 |
| NIH project number | 1R35GM161304-01 |
| Project ID | NIH-11257915 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults in intensive care with critical illness (e.g., trauma, burns, surgery) showing dysbiosis or gut barrier issues.
✕Less likely to help
Patients without critical illness or with stable gut microbiomes are unlikely to benefit from this research.
What this research studies
In people who are critically ill due to trauma, burns, or surgery, this project looks at how changes in the gut microbiome relate to organ damage and a dangerous inflammatory response. Researchers will study how gut bacteria interact with the body’s immune system, aiming to identify targets for treatment. The work includes examining 16S RNA sequencing data to understand which microbes are present and how they relate to patient outcomes. By uncovering the links between dysbiosis, gut barrier failure, and systemic inflammation, the team hopes to improve survival and recovery for ICU patients.
Why it matters
Potential benefit: Potentially leading to new therapies that protect the gut and reduce organ failure in critically ill patients.
How similar studies have gone: Previous work suggests a link between dysbiosis and worse outcomes, supporting the rationale for this approach.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Wang, Xiao — University of Illinois at Chicago
- Study coordinator: Wang, Xiao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.