Condition

Colorectal Cancer (CRC) clinical trials and research

• 54Clinical trials
• 3NIH research projects
• 1New in 30 days
• 24Countries

Newest Colorectal Cancer (CRC) clinical trials

All recruiting trials (54)

• Toripalimab Plus Cetuximab and Irinotecan for second-line right-sided colon cancer

  This phase II study tests whether a combo of toripalimab, cetuximab, and irinotecan helps adults with second-line, right‑sided, RAS/BRAF wild-type advanced colon cancer.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT07896681

• Intratumoral oncolytic virus plus immune checkpoint inhibitors in metastatic colorectal, gastric, or liver cancer

  Doctors are testing whether injecting an oncolytic virus directly into tumors along with immune checkpoint drugs is safe and may help people with advanced colorectal, gastric, or liver cancer who have tried many treatments.

  Recruiting Foshan Fosun Chancheng Hospital · Guangdong, Foshan · NCT07850882

• Targeted alpha-radiation therapy for NTSR1-positive tumors using SKL35501/SKL35502

  This early-phase trial tests whether a two-part approach—an imaging agent to find NTSR1-expressing tumors and a targeted alpha-ray therapy—can be safely used in adults with certain advanced solid tumors.

  Recruiting Phase 1 SK Life Science, Inc. · Glen Burnie, Maryland and 4 other locations · NCT07812805

• Pirfenidone plus PD-1 inhibitor with or without targeted radiotherapy for advanced colorectal cancer

  This study tests whether combining pirfenidone with a PD-1 inhibitor, with or without hypofractionated radiotherapy, is safe and helps people with unresectable or metastatic pMMR/MSS colorectal cancer who have exhausted standard therapies.

  Recruiting Phase 2 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07644286

• VMD-102 in liver cancer and other solid tumors

  This study tests VMD-102 to see if it is safe and tolerable and to find the best dose for further study in adults with advanced liver cancer and several other solid tumors.

  Recruiting at 2 sites Phase 1/2 VM Discovery, Inc. · Scottsdale, Arizona and 1 other locations · NCT07636785

• First-in-human imaging study of 68Ga-DFC413 and comparison with 68Ga-NNS309 in solid tumors

  This study tests a new radioactive imaging agent, 68Ga-DFC413, to see how it behaves in patients with several solid tumors and compares it to 68Ga-NNS309.

  Recruiting at 2 sites Phase 1 Novartis · Odense C and 1 other locations · NCT07630961

• Transcutaneous Electrical Acustimulation to Help Postoperative Bowel Function after Colorectal Cancer Surgery

  This study tests whether a gentle skin-stimulating therapy called TEA can help older adults recover bowel function after colorectal cancer surgery, compared with a sham procedure.

  Recruiting Sir Run Run Shaw Hospital · Binzhou, Shandong and 1 other locations · NCT07574502

• Plasma ctDNA methylation-guided adjuvant chemotherapy for stage I / low-risk stage II colorectal cancer

  This trial will test whether using a blood test for ctDNA methylation one month after surgery to guide adjuvant chemotherapy (such as capecitabine) helps clear ctDNA and lower recurrence risk in adults with stage I or low-risk stage II colorectal cancer who are ctDNA-positive.

  Recruiting Phase 2 Fudan University · Shanghai · NCT07562659

• KQB368 as a single-drug treatment for adults with advanced solid tumors

  This study tests whether taking KQB368 by mouth every day can help shrink tumors and is safe for adults with advanced solid cancers.

  Recruiting at 14 sites Phase 1 Kumquat Biosciences Inc. · Los Angeles, California and 13 other locations · NCT07542704

• Tegavivint treatment for metastatic colorectal cancer

  This trial will test tegavivint alone and with standard therapies in adults with metastatic colorectal cancer who have progressed after at least two prior systemic treatments.

  Recruiting Phase 1/2 HonorHealth Research Institute · Scottsdale, Arizona · NCT07463599

• Low-dose radiotherapy with pucotenlimab and CAPEOX for pMMR locally advanced rectal cancer

  This trial will try adding a single low dose of radiotherapy to the immunotherapy drug pucotenlimab plus CAPEOX chemotherapy before surgery to see if it improves tumor response in people with pMMR/MSS locally advanced rectal cancer.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guanggong · NCT07448142

• BPI-572270 in RAS-mutant advanced solid tumors (including NSCLC, CRC, PDAC)

  This study tests whether BPI-572270 is safe and tolerable in adults with RAS-mutant advanced solid tumors and looks for signs of clinical activity.

  Recruiting Phase 1/2 Betta Pharmaceuticals Co., Ltd. · Blacktown, New South Wales and 6 other locations · NCT07435038

• Combining RAS(ON) inhibitors with ivonescimab for adults with RAS‑mutant advanced solid tumors

  This trial will test whether combining RAS(ON) inhibitors with ivonescimab is safe and can shrink or control tumors in adults with advanced or metastatic solid tumors that have RAS mutations.

  Recruiting at 19 sites Phase 1/2 Revolution Medicines, Inc. · Scottsdale, Arizona and 18 other locations · NCT07397338

• RMC-5127 for advanced cancers with KRAS G12V mutation

  This trial will test whether the experimental drug RMC-5127, alone or with daraxonrasib or cetuximab, helps adults with advanced KRAS G12V-mutant solid tumors.

  Recruiting at 9 sites Phase 1 Revolution Medicines, Inc. · New Haven, Connecticut and 8 other locations · NCT07349537

• CBI-1214 T-cell engager for advanced MSS/MSI-L colorectal cancer

  This trial will test whether the experimental T-cell engager CBI-1214 is safe, reaches appropriate blood levels, and can shrink tumors in people with advanced or metastatic MSS/MSI-L colorectal cancer who have had prior treatment.

  Recruiting at 10 sites Phase 1 Cartography Biosciences · Phoenix, Arizona and 9 other locations · NCT07321106

• ABT-301 with tislelizumab and bevacizumab for pMMR/non‑MSI‑H advanced or metastatic colorectal cancer

  This trial will test whether adding the oral drug ABT-301 to fixed-dose tislelizumab and bevacizumab is safe and tolerable for adults with pMMR/non‑MSI‑H locally advanced or metastatic colorectal cancer who have had at least two prior systemic therapies.

  Recruiting Phase 1/2 Anbogen Therapeutics, Inc. · Liverpool, New South Wales and 14 other locations · NCT07244705

• BMS-986523 alone and with other cancer medicines for advanced KRAS-altered solid tumors

  This treatment tests whether BMS-986523, alone or combined with chemotherapy or immunotherapy, helps people with advanced KRAS-altered lung, colorectal, or pancreatic cancers.

  Recruiting at 6 sites Phase 1/2 Bristol-Myers Squibb · Baltimore, Maryland and 7 other locations · NCT07223047

• Blood test that looks for DNA methylation to detect colorectal cancer using Delta-HLD

  This will test a blood-based DNA methylation assay called Delta-HLD to see if it can detect colorectal cancer in people aged 45–75 undergoing routine screening colonoscopy.

  Recruiting Epiliquid Holding, Inc · Mendoza, Mendoza Province · NCT07168876

• TH9619 for advanced solid tumors (Phase 1/2)

  This trial will try different doses of TH9619 in adults with advanced solid tumors (including colorectal, head and neck, non-small cell lung, and gastroesophageal cancers) to find a recommended dose and check safety.

  Recruiting at 4 sites Phase 1/2 OneCarbon · Villejuif and 3 other locations · NCT07151040

• How the CES1 liver enzyme affects capecitabine levels in people with colorectal, gastric, or esophageal cancer

  This project will see if differences in the CES1 enzyme change how capecitabine is processed and whether that affects side effects like hand‑foot syndrome in adults starting capecitabine with oxaliplatin for colorectal, gastric, or esophageal cancer.

  Recruiting Erasmus Medical Center · Rotterdam · NCT07114627

• HLX43 (anti‑PD‑L1 antibody‑drug conjugate) treatment for advanced colorectal cancer

  This study will try three doses of HLX43, an anti‑PD‑L1 antibody‑drug conjugate, to see if it is safe and helps people with advanced colorectal cancer who have already received standard treatment.

  Recruiting at 2 sites Phase 2 Shanghai Henlius Biotech · Beijing and 1 other locations · NCT07106892

• AI-assisted colonoscopy to find and classify colorectal lesions

  This trial tries to see if using AI during routine colonoscopy helps doctors find more adenomas and better classify colorectal lesions in adults.

  Recruiting Instituto do Cancer do Estado de São Paulo · São Paulo, São Paulo · NCT07066046

• Fractionated liposomal irinotecan with 5‑FU/LV and bevacizumab for second-line advanced colorectal cancer

  This study will test whether giving liposomal irinotecan in split doses together with 5‑FU/LV and bevacizumab helps people with advanced colorectal cancer who need a second-line treatment after oxaliplatin-based therapy.

  Recruiting Phase 2 Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT07047560

• Smart swallowable pill to measure gut oxidation in colon inflammation and cancer

  This pilot will test whether a swallowed sensor pill can measure gut oxidation levels in people with ulcerative colitis or colorectal cancer before and three months after treatment.

  Recruiting Radboud University Medical Center · Nijmegen, Gelderland · NCT07046468

• PD-1–edited tumor-infiltrating T cells for advanced colorectal cancer

  This test uses a patient's own tumor-infiltrating T cells, edited to remove PD‑1, to see if the treatment is safe and may help adults with advanced colorectal cancer who no longer have standard treatment options.

  Recruiting Phase 1 Ruijin Hospital · Shanghai, None Selected · NCT07035002

• Fruquintinib plus FOLFIRI for second-line metastatic colorectal cancer

  This study will test whether adding fruquintinib to FOLFIRI helps people with metastatic colorectal cancer who progressed after first-line FOLFOX plus bevacizumab.

  Recruiting at 14 sites Phase 2 SCRI Development Innovations, LLC · Denver, Colorado and 13 other locations · NCT07011576

• Examining the large intestine with a camera capsule in patients with blood infections from gut bacteria

  This study is testing if a special camera pill can help find colorectal cancer and precancerous growths in adults who have had blood infections from gut bacteria.

  Recruiting Odense University Hospital · Odense · NCT06919068

• Urine protein markers to predict and monitor response to pre-surgery therapy in colorectal cancer.

  This project will test whether urine proteins can predict and track how people with locally advanced colorectal cancer respond to neoadjuvant (pre-surgery) therapy.

  Recruiting Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Chaoyang District · NCT06904677

• JYP0015 for adults with advanced RAS‑mutant solid tumors

  This trial tests whether the oral drug JYP0015 is safe and can shrink tumors in adults whose advanced solid cancers have specific RAS mutations.

  Recruiting Phase 2 Guangzhou JOYO Pharma Co., Ltd · Beijing, Beijing Municipality · NCT06895031

• Exploring the link between colon cancer and chronic kidney disease

  This study is trying to see how chronic kidney disease affects the growth of early-stage colon cancer in patients who are having surgery.

  Recruiting National Cancer Institute, Naples · Naples · NCT06886282

• Using MRI to Improve Radiotherapy Planning for Rectal Cancer

  This study is testing if using regular MRI scans can help doctors better plan radiotherapy for patients with rectal cancer.

  Recruiting NHS Greater Glasgow and Clyde · Glasgow · NCT06822634

• Using deep learning and Raman spectroscopy for early cancer diagnosis

  This study is trying to see if a new deep learning tool using blood samples can help spot early signs of different types of cancer, like colorectal and gastric cancers, in both healthy people and those already diagnosed.

  Recruiting at 4 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Nanchang, Jiangxi and 3 other locations · NCT06822413

• Investigating how endocrine disruptors affect gut bacteria and colorectal cancer risk

  This study is trying to see if certain chemicals that mess with hormones can change gut bacteria and increase the risk of colorectal cancer in people.

  Recruiting Poitiers University Hospital · Poitiers · NCT06809660

• Combination therapy for advanced colorectal cancer

  This study is testing a new combination treatment for people with advanced colorectal cancer to see if it can help them respond better to therapy and live longer compared to a standard treatment.

  Recruiting Phase 3 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT06791512

• Investigating OKN4395 and Pembrolizumab for Solid Tumors

  This study is testing a new drug called OKN4395, alone and with another drug called pembrolizumab, to see if it can help people with solid tumors who have run out of other treatment options.

  Recruiting at 10 sites Phase 1 Epkin · Beverly Hills, California and 9 other locations · NCT06789172

• Personalized vaccine combined with third-line therapy for advanced colorectal cancer

  This study is testing if a personalized vaccine, along with standard treatment, can help people with advanced colorectal cancer who haven't responded to previous therapies.

  Recruiting at 2 sites The First Affiliated Hospital of Nanchang University · Nanchang, Jiangxi and 1 other locations · NCT06751966

• Personalized vaccine and therapy for advanced colorectal cancer

  This study is testing a personalized vaccine combined with standard treatment for people with advanced colorectal cancer who haven't improved after previous therapies.

  Recruiting at 2 sites The First Affiliated Hospital of Nanchang University · Nanchang, Jiangxi and 1 other locations · NCT06751953

• Personalized vaccine and second-line therapy for advanced colorectal cancer

  This study is testing a personalized vaccine combined with standard therapy to see if it helps people with advanced colorectal cancer who haven't responded to their first treatment.

  Recruiting at 2 sites The First Affiliated Hospital of Nanchang University · Nanchang, Jiangxi and 1 other locations · NCT06751940

• Personalized peptide vaccine combined with second-line therapy for advanced colorectal cancer

  This study is testing a personalized vaccine combined with standard treatment to see if it helps people with advanced colorectal cancer who haven't responded to their first treatment.

  Recruiting at 2 sites The First Affiliated Hospital of Nanchang University · Nanchang, Jiangxi and 1 other locations · NCT06751914

• Identifying gut microbiome biomarkers for early colorectal cancer screening in Portugal

  This study is trying to find specific gut bacteria in stool samples from people aged 40-74 in Lisbon to see if they can help detect early signs of colorectal cancer more accurately.

  Recruiting Gulbenkian Institute for Molecular Medicine · Lisbon, Lisbon District · NCT06741293

• Gut microbiome clues for colorectal cancer risk, progression, and outcomes

  This study will try to find whether patterns in stool microbes can mark disease stage, prognosis, or treatment response in people aged 40–74 newly diagnosed with colorectal cancer.

  Recruiting at 2 sites Gulbenkian Institute for Molecular Medicine · Lisbon, Lisbon District and 1 other locations · NCT06734156

• Reducing sitting time and increasing daily activity during cancer treatment

  This project will try a digital self-management program plus physiotherapist support to help people with breast, prostate, or colorectal cancer who are starting neo- or adjuvant treatment sit less and feel better during and after treatment.

  Recruiting at 2 sites Mälardalen University · Uppsala and 1 other locations · NCT06719206

• IM96 CAR-T cell therapy for advanced colorectal cancer

  This study is testing a new CAR-T cell therapy to see if it can help people with advanced colorectal cancer feel better and improve their treatment options.

  Recruiting Phase 1 Beijing Immunochina Medical Science & Technology Co., Ltd. · Beijing, Beijing Municipality · NCT06718738

• Registry of digestive tumors in Spain

  This study is collecting information on digestive tumors in adults in Spain to see how to improve diagnosis and treatment for patients.

  Recruiting Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) · Madrid, Madrid · NCT06711211

• FIT stool testing to monitor for return of colorectal cancer after surgery

  We will try whether a simple stool FIT test can detect returning colorectal cancer or significant polyps in adults who had curative bowel surgery and are due a 3‑year surveillance colonoscopy or CT colon.

  Recruiting Nottingham University Hospitals NHS Trust · Nottingham · NCT06689293

• Evaluating Gixam for detecting precancerous polyps using tongue images

  This study is testing a new device that takes pictures of the tongue to see if it can help find precancerous polyps in the colon or rectum for people aged 45-85 who are going for a screening colonoscopy.

  Recruiting Phase 2 Jubaan Ltd. · Portland, Oregon · NCT06612281

• Evaluating RMC-9805 for KRAS G12D-Mutant Solid Tumors

  This study is testing a new drug called RMC-9805 to see if it can safely help adults with solid tumors that have a specific KRAS G12D mutation.

  Recruiting at 17 sites Phase 1 Revolution Medicines, Inc. · Sacramento, California and 16 other locations · NCT06040541

• Testing KO-2806 for advanced solid tumors

  This study is testing a new treatment called KO-2806 for adults with advanced solid tumors that have certain genetic changes to see if it can help them feel better.

  Recruiting at 38 sites Phase 1 Kura Oncology, Inc. · Phoenix, Arizona and 37 other locations · NCT06026410

• Evaluating GI-102 for advanced solid tumors with or without other cancer drugs

  This study is testing a new cancer treatment called GI-102, both on its own and with other cancer drugs, to see how safe it is and how well it works for people with advanced solid tumors.

  Recruiting at 11 sites Phase 1/2 GI Innovation, Inc. · Scottsdale, Arizona and 10 other locations · NCT05824975

• Assessing safety and efficacy of new treatments for advanced solid tumors

  This study is testing two new treatments for patients with advanced solid tumors to see if they are safe and effective.

  Recruiting at 10 sites Phase 1/2 Lumara Bio Oncologics GmbH · Melbourne and 9 other locations · NCT05706129

• Evaluating RMC-6236 for advanced solid tumors with specific RAS mutations

  This study is testing a new drug called RMC-6236 to see if it can help adults with advanced solid tumors that have certain RAS mutations.

  Recruiting at 21 sites Phase 1/2 Revolution Medicines, Inc. · Orange, California and 20 other locations · NCT05379985

• Zanzalintinib with immune checkpoint drugs for advanced solid tumors

  This trial will test whether zanzalintinib alone or combined with immune drugs (nivolumab, with or without ipilimumab or relatlimab) is safe and helps people with advanced or metastatic solid tumors such as renal cell, prostate, urothelial, and liver cancers.

  Recruiting at 101 sites Phase 1 Exelixis · Phoenix, Arizona and 121 other locations · NCT05176483

• Collecting blood samples to improve colorectal cancer detection

  This study is trying to see if blood samples can help improve the detection of colorectal cancer and advanced adenomas in people who are at risk or have just been diagnosed.

  Recruiting at 4 sites Universal Diagnostics · Chula Vista, California and 15 other locations · NCT04792684

• Innovative therapies for liver metastases in cancer patients

  This study is testing new ways to understand and treat liver tumors in patients with advanced colorectal and pancreatic cancer to see if it can lead to better therapies.

  Recruiting IRCCS San Raffaele · Milan, Milan · NCT04622423

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How KRAS mutations influence fat cell development to worsen colorectal cancer

  This study is looking at how changes in the KRAS gene help colorectal cancer grow and spread by encouraging fat cells to form around the tumor, with the goal of finding new ways to treat patients with advanced colorectal cancer.

  NIH research Stanford University · Stanford, United States · NIH-11199641

• Preventing colorectal cancer using a new drug in a rat model.

  This study is looking at how well a new drug called TPST-1495 can help prevent colorectal cancer in people with Familial Adenomatous Polyposis (FAP), using a special rat model to see if it works safely and effectively.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-10927554

• Preventing colorectal cancer using Urolithin A in animal models

  This study is looking at whether a natural compound called Urolithin A, found in some fruits and nuts, can help prevent colorectal cancer by testing it in mice that have a similar condition to humans, with hopes that it could lead to new ways to protect people from this cancer.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-10885222

Related topics

Quick answers

How many Colorectal Cancer (CRC) clinical trials are recruiting right now?

54, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 24 countries. The most sites are in China (19 trials), United States (17 trials), United Kingdom (5 trials), Spain (5 trials), France (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 11, Phase 1/2: 10, Phase 2: 9, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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