Examining the gut microbiota in patients with anorexia nervosa

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the relationship between the severity of anorexia nervosa symptoms and alterations in the intestinal microbiota. It will involve characterizing the gut microbiota of malnourished anorexia nervosa patients compared to healthy controls using DNA sequencing and metagenomic methods. The study will also explore how changes in the microbiota may affect intestinal permeability, inflammation, and psychiatric symptoms associated with anorexia nervosa.

Why it matters

Who can join: the full rules

Inclusion Criteria:

For patients:

* Patients aged ≥18 years;
* Anorexia according to DSM-5 and CIDI (Composite International Diagnostic Interview);
* Body mass index (BMI) (P/T2) \< 15;
* Hospitalization for nutrition rehabilitation;
* Covered by a health insurance;
* Informed consent form signed.

For Healthy Volunteers:

* Aged ≥18 years;
* 18.5 \< BMI (P/T2) \< 25;
* Covered by a health insurance;
* Informed consent form signed.

Exclusion Criteria:

For patients:

* Patients no-responding all criteria of DSM-5 or CIDI scores;
* Taken of antibiotic treatment 2 months / or laxativ 3 weeks before hospitalization;
* Somatic comorbidity should perturb intestinal microbiota (Crohn's disease, diabetes and all other chronic inflammatory diseases);
* Patients under guardianship;
* Patients covered by french AME scheme.

For Healthy Volunteers:

* Any disease should perturb intestinal microbiota;
* Recent ponderal variation;
* Taken of antibiotic treatment 2 months or laxativ 3 weeks before hospitalization;
* Under guardianship;
* Covered by french AME scheme.

Where it's running

• Service de Nutrition Clinique, Hôpital Paul Brousse (APHP)
  Villejuif, France Recruiting

Study contacts

• Principal investigator: Mouna HANACHI GUIDOUM, MD — Service de Nutrition Clinique, Hôpital Paul Brousse - APHP
• Study coordinator: Mouna HANACHI GUIDOUM, MD
• Email: mouna.hanachi@aphp.fr
• Phone: + 33 6 70 39 42 37

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.