Investigating how endocrine disruptors affect gut bacteria and colorectal cancer risk

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines the relationship between endocrine disruptors and colorectal cancer by comparing gut microbiota in patients with colorectal cancer to those without. It involves collecting stool, hair, and urine samples from 200 participants, divided into two groups of 100. Participants will complete a questionnaire regarding their exposure to endocrine disruptors, and routine care data will be collected over five years. The goal is to identify specific endocrine disruptors linked to dysbiosis and colorectal cancer development.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Scheduled endoscopy during the inclusion visit or within 18 months following this consultation.
* Signed consent from the patient after clear and fair information about the study is provided.
* Patient is free of guardianship, curatorship, or dependency.
* Patient is covered by a social security system or through a third party.

Exclusion Criteria:

* Patients receiving treatment for chronic inflammatory bowel disease;
* Patients with hereditary colorectal cancer;
* Use of antibiotics, probiotics, or prebiotics within four weeks prior to stool sample collection;
* Patients who have undergone neoadjuvant chemotherapy or radiotherapy;
* Patients who have had previous surgical resection;
* Patients under enhanced protection: minors, individuals deprived of liberty by judicial or administrative decision, individuals residing in healthcare or social institutions, and adults under legal protection;
* Pregnant and/or breastfeeding women.

Exclusion Criteria During Study Participation:

* Patients presenting any of the following during their participation in the study will be excluded:
* Use of antibiotics, probiotics, or prebiotics before stool collection (between inclusion and stool collection, which may occur within the month);
* Endoscopy not performed within 18 months following inclusion;
* Failure to send/receive stool samples

Where it's running

• CHU de Poitiers
  Poitiers, France Recruiting

Study contacts

• Study coordinator: Violaine RANDRIAN, Doctor
• Email: violaine.randrian@chu-poitiers.fr
• Phone: 00335 49 44 42 93

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.