Gut-disease signals linked to HIV and heart disease
Official title: Multi-omic signatures of gut dysbiosis and cardiovascular comorbidities associated with HIV infection
Funded at Albert Einstein College of Medicine · NIH-11380801 · Data updated 2026-11-12
This project will look at how gut bacteria and related molecules are connected to heart and blood vessel problems in people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $703,501 |
| NIH project number | 5R01HL170904-04 |
| Project ID | NIH-11380801 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with HIV infection who are part of the MWCCS cohort and have available cardiovascular imaging data.
✕Less likely to help
If you do not have HIV or are not part of the MWCCS cohort, this study would not directly benefit you.
What this research studies
If you have HIV, your gut bacteria and immune system can influence your heart and blood vessels. The study will analyze data from large HIV cohorts to map multi-omics signatures (gut microbes, genes, proteins) to various cardiovascular measurements like carotid plaques and heart function. Researchers will combine microbiome, gene, and protein data with imaging tests to understand shared pathways between HIV-related inflammation and cardiovascular disease. The goal is to identify biomarkers and possible pathways that could guide future interventions to reduce heart risks for people with HIV.
Why it matters
Potential benefit: Findings could lead to new ways to prevent or treat heart disease in people living with HIV.
How similar studies have gone: Previous work linked specific gut bacteria and immune markers to carotid artery disease in HIV patients, supporting this multi-omics approach.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Qi, Qibin — Albert Einstein College of Medicine
- Study coordinator: Qi, Qibin
Related research
Other NIH-funded projects on the same topics.
-
Gut microbes and blood markers linked to heart and blood vessel problems in people with HIV
This project looks for patterns in gut microbes and blood-based markers that relate to heart and blood vessel problems in people living with HIV.
-
Understanding how genetic changes in blood cells relate to heart disease in people with HIV
A study will look at how age-related blood cell mutations and large chromosomal changes might contribute to heart disease risk in people living with HIV.
-
Microbial Dysbiosis and Its Role in Pancreatic Cancer
A doctor-researcher team at Northwestern University is studying how gut bacteria influence pancreatic cancer and its response to immunotherapy to find new ways to help patients.
-
From Symbiosis to Dysbiosis: How Resolving Inflammation Could Restore Your Mouth’s Balance
This grant explores how turning off the harmful inflammation in periodontitis and promoting natural healing could help restore the mouth’s healthy balance.
-
Cardiac health and protein markers in kids with perinatal HIV exposure or infection
A study from Duke aims to understand heart health and protein biomarkers in children who were exposed to or infected with HIV at birth, especially in sub-Saharan Africa.
-
Antibiotics, gut health, and skin reactions in kids
A small study in children will look at whether antibiotic use and gut bacteria play a role in hives and related symptoms that children sometimes get after antibiotics.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.