Modulating the peri-implant microbiome to prevent titanium-related inflammation
Official title: Commensal modulation of Peri-implant Microbiome Dysbiosis via Veillonella parvula
Funded at Rutgers Biomedical and Health Sciences · NIH-11375062 · Data updated 2026-11-12
This project looks at how a common oral bacteria, Veillonella parvula, helps protect other microbes around dental implants from oxidative stress and how this might affect inflammation and bone loss near implants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $634,762 |
| NIH project number | 5R01DE031746-05 |
| Project ID | NIH-11375062 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with dental implants at risk for peri-implantitis or experiencing implant-associated inflammation may benefit from future developments based on this research.
✕Less likely to help
Individuals without dental implants or without peri-implant inflammation are unlikely to directly benefit from this study.
What this research studies
Peri-implantitis is a painful condition where bone around dental implants deteriorates and current antibacterial treatments often fail. The study investigates how titanium particles from implants cause oxidative stress in the mouth and alter the tiny ecosystem of bacteria on implants. Researchers will explore the genetic toolkit of Veillonella parvula, a key player in oral biofilms, to understand how it survives stress and interacts with other pathogens. By focusing on the katA antioxidant system, the team hopes to uncover mechanisms that could be targeted to preserve biofilm balance and reduce inflammation.
Why it matters
Potential benefit: If successful, this work could lead to new strategies to prevent or mitigate peri-implant inflammation and bone loss, improving implant longevity and oral health.
How similar studies have gone: Preliminary data suggest that microbiome dynamics around implants influence inflammation, but the exact role of Veillonella parvula and titanium-related oxidative stress is an area of active investigation.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Kotsakis, Georgios — Rutgers Biomedical and Health Sciences
- Study coordinator: Kotsakis, Georgios
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.