How succinate affects gut health and inflammation as we age
Succinate triggers gut dysbiosis and activates SUCNR1 to enhance inflammaging
['FUNDING_R01'] · UNIVERSITY OF VIRGINIA · NIH-11247689
This study is looking at how a substance called succinate, which is connected to aging, affects the gut bacteria and inflammation in both young and old mice, with the hope of finding new ways to improve health as we age.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-11247689 on ClinicalTrials.gov |
What this research studies
This research investigates the role of succinate, a metabolite linked to aging, in altering gut microbiota and promoting chronic inflammation known as inflammaging. By studying both young and old mice, the researchers aim to understand how increased succinate levels impact gut health and immune responses. The study will explore the mechanisms by which succinate influences inflammation and gut dysbiosis, potentially leading to new strategies for managing age-related health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing chronic inflammation or related health issues.
Not a fit: Patients who are not experiencing age-related inflammation or have no gut health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve gut health and reduce inflammation in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between gut microbiota and inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, XIN — UNIVERSITY OF VIRGINIA
- Study coordinator: LI, XIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.