DS-ARC: A smartphone-based cognitive test for Down syndrome–associated Alzheimer’s disease

Who could benefit from this research

What this research studies

People with Down syndrome are at high risk for developing Alzheimer’s–related dementia, and this project creates a quick, daily smartphone test to track cognitive changes in real life. Over one week, participants will complete brief tasks on their phones several times per day to reduce day-to-day fluctuations and improve reliability. The study builds on prior work showing that smartphone methods can relate to brain biomarkers and reduce the need for frequent clinic visits. By capturing natural, within-day variation, DS-ARC aims to identify early, pre-symptomatic changes that could guide future prevention efforts.

Why it matters

Where this research is happening

• Washington University
  Saint Louis, United States Active

Researchers

• Principal investigator: Hassenstab, Jason J — Washington University
• Study coordinator: Hassenstab, Jason J

Related research

Other NIH-funded projects on the same topics.

• DS-ARC: Smartphone-based cognitive check for people with Down syndrome at risk for Alzheimer’s

  A smartphone-based cognitive test is being developed and tested for people with Down syndrome who may develop Alzheimer’s disease, to track changes quietly in daily life.

  NIH research Washington University · Saint Louis, United States · NIH-11588336

• Remote monitoring of Alzheimer’s changes in adults with Down syndrome

  A study tests remote (at-home) ways to track Alzheimer’s-related thinking changes in adults with Down syndrome.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11532997

• How sleep and body temperature affect Alzheimer's risk in adults with Down syndrome

  Researchers will follow adults with Down syndrome over several years to learn whether sleep problems and lower body temperature are linked to earlier Alzheimer's changes.

  NIH research New York University School of Medicine · New York, United States · NIH-11508145

• DS-ARC: A smartphone-based cognitive test for Down syndrome-associated Alzheimer's disease

  A new smartphone app will measure day-to-day thinking changes in adults with Down syndrome who may develop Alzheimer’s disease, helping catch early signs in a convenient, real-world way.

  NIH research Washington University · Saint Louis, United States · NIH-11504765

• DS-ARC: A Remote Digital Cognitive Test for Down Syndrome-Related Alzheimer’s Disease

  A smartphone-based cognitive test is being developed to help people with Down syndrome who are at risk for Alzheimer’s disease understand and track early brain changes.

  NIH research Washington University · Saint Louis, United States · NIH-11504762

• DS-ARC: A smartphone test to track cognitive change in people with Down syndrome at risk for Alzheimer’s

  A smartphone-based cognitive test is being developed and tested to help monitor early symptoms of Alzheimer’s disease in people with Down syndrome.

  NIH research Washington University · Saint Louis, United States · NIH-11504761

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.