Immune and breathing measurements in children with Down syndrome and pneumonia
Relationship Between Immune Profile and Respiratory Parameters in Down Syndrome Children With Acute Pneumonia: Pre-Intervention Analysis
This project tests whether blood immune markers and simple breathing measures are linked in children with Down syndrome who have acute pneumonia.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 1 Year to 6 Years |
| Sex | All |
| Sponsor | Badr University Academic / other |
| Locations | 2 sites (Cairo and 1 other locations) |
| Trial ID | NCT07366593 on ClinicalTrials.gov |
What this trial studies
This is a descriptive, cross-sectional analysis of baseline data from 40 children with Down syndrome enrolled before an intervention. Investigators measured serum IgG, IgA, and IgM by nephelometry, total white blood cell count by automated analyzer, respiratory rate by manual count, and oxygen saturation by pulse oximetry. They used Pearson or Spearman correlation tests to examine relationships among immune markers, respiratory parameters, and age. The analysis aims to characterize associations at presentation rather than to test a treatment.
Who should consider this trial
Good fit: Children with Down syndrome who have acute bronchopneumonia, sufficient cognitive ability to cooperate with measurements, and no severe congenital heart defects or known primary immunodeficiencies.
Not a fit: Children with severe congenital heart defects, primary immunodeficiencies, or without acute pneumonia were excluded and are unlikely to benefit from the study's findings.
Why it matters
Potential benefit: If findings show clear links between immune markers and respiratory status, clinicians might better identify children at higher risk of respiratory compromise and tailor monitoring.
How similar studies have performed: Prior work has documented immune abnormalities in people with Down syndrome, but direct correlations between serum immunoglobulins and respiratory measures during acute pneumonia are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Down Syndrome with acute bronchopneumonia * sufficient cognitive ability Exclusion Criteria: * severe congenital heart defects * primary immunodeficiencies
Where this trial is running
Cairo and 1 other locations
- Badr university — Cairo, Egypt (Recruiting)
- Mona Mohamed Abdelkhalek — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Mona Mohamed Abdelkhalek, assistance prof
- Email: 3m.sons@gmail.com
- Phone: 002021024056108
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.