DS-ARC: Smartphone-based cognitive check for people with Down syndrome at risk for Alzheimer’s

Who could benefit from this research

What this research studies

This project aims to create a digital, pocket-friendly way to monitor cognition in people with Down syndrome who are at risk for DS-AD. By collecting short, frequent tasks on a smartphone during real-life activities, the study hopes to capture true cognitive changes over time rather than single clinic visits. The approach builds on prior research showing mobile tests can align with biological markers and reduce the burden of in-clinic testing. Participants will complete several brief tasks across a week, helping doctors understand early DS-AD progression in a natural setting. Results could inform earlier interventions and better monitoring for DS-AD in everyday life.

Why it matters

Where this research is happening

• Washington University
  Saint Louis, United States Active

Researchers

• Principal investigator: Hassenstab, Jason J — Washington University
• Study coordinator: Hassenstab, Jason J

Related research

Other NIH-funded projects on the same topics.

• Remote monitoring of Alzheimer’s changes in adults with Down syndrome

  A study tests remote (at-home) ways to track Alzheimer’s-related thinking changes in adults with Down syndrome.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11532997

• How sleep and body temperature affect Alzheimer's risk in adults with Down syndrome

  Researchers will follow adults with Down syndrome over several years to learn whether sleep problems and lower body temperature are linked to earlier Alzheimer's changes.

  NIH research New York University School of Medicine · New York, United States · NIH-11508145

• DS-ARC: A smartphone-based cognitive test for Down syndrome–associated Alzheimer’s disease

  A smartphone-based cognitive test will be developed and tested to help detect early signs of dementia in adults with Down syndrome.

  NIH research Washington University · Saint Louis, United States · NIH-11504766

• DS-ARC: A smartphone-based cognitive test for Down syndrome-associated Alzheimer's disease

  A new smartphone app will measure day-to-day thinking changes in adults with Down syndrome who may develop Alzheimer’s disease, helping catch early signs in a convenient, real-world way.

  NIH research Washington University · Saint Louis, United States · NIH-11504765

• DS-ARC: A Remote Digital Cognitive Test for Down Syndrome-Related Alzheimer’s Disease

  A smartphone-based cognitive test is being developed to help people with Down syndrome who are at risk for Alzheimer’s disease understand and track early brain changes.

  NIH research Washington University · Saint Louis, United States · NIH-11504762

• DS-ARC: A smartphone test to track cognitive change in people with Down syndrome at risk for Alzheimer’s

  A smartphone-based cognitive test is being developed and tested to help monitor early symptoms of Alzheimer’s disease in people with Down syndrome.

  NIH research Washington University · Saint Louis, United States · NIH-11504761

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.