Effects of Aerobic Exercise and Diet on Weight in Children with Down Syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the impact of aerobic exercise alone versus aerobic exercise combined with a low-calorie diet on reducing adiposity and improving body mass index (BMI) in children with Down syndrome. Participants aged 8 to 16 years who are overweight or obese will be randomly assigned to one of two groups: one will engage in aerobic exercise, while the other will follow the same exercise regimen along with a low-calorie diet. The study will utilize calibrated scales, stadiometers, and waist circumference measurements to assess changes in weight and body composition over a 10-month period. The research is being conducted at a rehabilitation clinic in Lahore, Pakistan.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age (8-16) years.
* Both Genders (Male and Female).
* BMI-for-age percentile (at or above 85th percentile is overweight, and at or above 95th percentile is considered as obese)
* Children with generally stable health condition, without significant co-morbidities that might affect diet or exercise interventions.
* Consent form signed by parents, along with written approval by the physician.

Exclusion Criteria:

* History of any previous medical disease.
* Previous Participation in any Weight Loss Exercise Program.
* Participants following any specific diet plan from last 6 months.
* Exclusion of children on medication that could affect weight or metabolism.
* Children with physical disabilities that prevent them from safely participating in aerobic exercise.
* Children with dietary restrictions or food allergies.
* Children with severe cognitive impairments that prevent them from engaging in exercise program.

Where it's running

• Jannat Arshad
  Lahore, Punjab Province, Pakistan Recruiting

Study contacts

• Principal investigator: Jannat Arshad, MS-PT — Riphah International University
• Study coordinator: Imran Amjad, PhD
• Email: imran.amjad@riphah.edu.pk
• Phone: 9233224390125

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• JAK inhibitor treatment for Down syndrome in children and young adults

  This study tests whether 6 months of tofacitinib can help improve safety and neurodevelopment in people with Down syndrome aged 6 to 22, compared with placebo.

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• Jump rope to improve navicular drop and foot posture in children with Down syndrome

  This project will test whether adding jump-rope exercises to play activities helps improve foot posture in 4–15-year-old children with Down syndrome who have navicular drop.

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• Thymus removal and immune aging in people with Down syndrome

  This study will try to see if removing part of the thymus affects immune health over time in people aged 1 and older with Down syndrome, comparing those who had thymectomy to those who did not and to unaffected household relatives.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07416201

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.