Brain network problems tied to memory and thinking in adults with Down syndrome
Default mode network dysfunction in Down Syndrome
This project looks at why key brain cells and networks that support memory and self-awareness break down in adults with Down syndrome.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Joseph's Hospital and Medical Center NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project ID | NIH-11457058 on NIH RePORTER |
What this research studies
You would hear how researchers compare brain samples and cellular data from people with Down syndrome who have dementia to those who do not. They focus on two connected brain areas (the frontal cortex and precuneus) that are important for memory and self-awareness and are part of the brain's default mode network. The team examines tau and amyloid protein changes and reads the activity of genes in single neurons to find patterns linked to decline. Findings may point to the cellular steps that cause dementia in Down syndrome and suggest targets for future treatments.
Who could benefit from this research
Good fit: Ideal candidates are adults with Down syndrome, especially those in midlife or older, whether or not they currently have memory or thinking problems.
Not a fit: People without Down syndrome or very young children with Down syndrome are unlikely to benefit directly from this specific project.
Why it matters
Potential benefit: If successful, this work could reveal molecular targets that lead to new ways to prevent or slow dementia in people with Down syndrome and related Alzheimer disease.
How similar studies have performed: Previous research has shown that tau and amyloid pathology occur in Down syndrome, but comparing single-neuron gene activity between demented and non-demented people with Down syndrome is a newer approach.
Where this research is happening
Phoenix, United States
- St. Joseph's Hospital and Medical Center — Phoenix, United States (Active)
Researchers
- Principal investigator: Mufson, Elliott Jay — St. Joseph's Hospital and Medical Center
- Study coordinator: Mufson, Elliott Jay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.