Condition

Down Syndrome (Trisomy 21) clinical trials and research

• 8Clinical trials
• 4Countries

Newest Down Syndrome (Trisomy 21) clinical trials

All recruiting trials (8)

• Non-invasive fetal cell test to check fetal chromosomal status in early pregnancy

  A large, non-invasive blood test in pregnant people between 10 and 20 weeks looks for fetal cells in the mother's blood to see if the baby has certain chromosomal conditions, comparing results to invasive or postnatal diagnoses.

  Recruiting at 9 sites BillionToOne Inc. · Phoenix, Arizona and 8 other locations · NCT07643896

• Vascular Health in Adults with Down Syndrome

  This study tests how aging affects blood vessel function and stiffness in adults with Down syndrome compared with adults without Down syndrome.

  Recruiting University of Nevada, Las Vegas · Las Vegas, Nevada · NCT07630207

• Two-week intensive brain-focused therapy program for children with neurodevelopmental and chromosomal conditions

  This program will try a two-week, individualized multimodal neurorehabilitation approach for children about 4–12 years old with neurodevelopmental or chromosomal conditions to see if it improves attention, motor skills, communication, and daily functioning.

  Recruiting Healing Hope International · The Woodlands, Texas · NCT07493096

• Trust in people with intellectual disability: a look at Down syndrome and Fragile X syndrome

  This study tests how people with Down syndrome or Fragile X syndrome process trust in social interactions to see how trust decisions differ in these groups.

  Recruiting Hospices Civils de Lyon · Bron · NCT07434037

• AEF0217 for improving daily living and thinking in Down syndrome

  This trial will test whether daily AEF0217 helps adolescents and adults with Down syndrome improve daily living skills, thinking, sleep, and quality of life.

  Recruiting at 7 sites Phase 2 Aelis Farma · Bordeaux and 9 other locations · NCT07334912

• Levetiracetam to prevent seizures in adults with Down syndrome and Alzheimer's disease

  This trial will test whether the anti-seizure medicine levetiracetam can prevent tonic-clonic seizures and slow cognitive decline in adults over 40 who have Down syndrome and symptomatic Alzheimer's disease.

  Recruiting Phase 3 Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Granada, Andalusia and 4 other locations · NCT07234695

• Orofacial function and sleep breathing in infants with Down syndrome

  This study will test whether measures of mouth and facial muscle function and a non‑nutritive sucking recording at six months can help detect sleep apnea in infants with Down syndrome.

  Recruiting Hospices Civils de Lyon · Bron · NCT07195253

• Improving sleep quality in individuals with Down syndrome

  This study is testing a new online program to help young people with Down syndrome sleep better and feel happier in their daily lives.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06783725

Related topics

Quick answers

How many Down Syndrome (Trisomy 21) clinical trials are recruiting right now?

8, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (4 trials), France (3 trials), Spain (2 trials), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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