Condition

Diabetic Kidney Disease clinical trials and research

• 19Clinical trials
• 39NIH research projects
• 11Countries

Newest Diabetic Kidney Disease clinical trials

All recruiting trials (19)

• MTX-439 safety test in healthy adults and adults with diabetic kidney disease

  This phase 1 study tests MTX-439 in healthy adults and adults with diabetic kidney disease to see if it is safe and how the body handles it.

  Recruiting Phase 1 Mediar Therapeutics · Melbourne, Victoria · NCT07473323

• Pharmacist prescribing to improve kidney care for people with type 2 diabetes

  This project will test whether pharmacist prescribing guided by step-by-step algorithms helps adults with type 2 diabetes and early diabetic kidney disease who lack a regular doctor start recommended kidney‑protecting medications.

  Recruiting Nova Scotia Health Authority · Halifax, Nova Scotia · NCT07169422

• Formoterol for diabetic kidney disease

  This trial will test whether adding formoterol fumarate to usual care helps adults with type 2 diabetes who have moderate diabetic kidney disease.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT07022418

• Effects of low oxygen levels on kidney function in healthy individuals and diabetes patients

  This study is testing how low oxygen levels affect kidney function in healthy people and those with diabetes to see if there are different risks for kidney health.

  Recruiting Poitiers University Hospital · Poitiers · NCT06846034

• AP303 safety, tolerability, and dosing in people with diabetic kidney disease

  This study will try a 2-week oral dose of AP303 or placebo in adults with type 2 diabetic kidney disease to see if it is safe and how the body processes it.

  Recruiting Phase 1 Alebund Pharmaceuticals · Beijing, Beijing Municipality · NCT06666283

• Evaluating R3R01 for reducing protein in urine for diabetic kidney disease

  This study is testing if a new drug called R3R01 can help adults with type 2 diabetes and kidney disease lower the protein in their urine and improve their kidney function.

  Recruiting Phase 2 River 3 Renal Corp. · Copenhagen, Copenhagen · NCT06600412

• Using advanced MRI techniques to evaluate diabetic kidney disease

  This study is testing whether advanced MRI scans can help doctors better diagnose and track kidney problems in people with diabetes without needing invasive tests.

  Recruiting Shengjing Hospital · Shenyang, Liaoning · NCT06452862

• Effects of SGLT2 inhibitors on kidney function in Type 2 diabetes

  This study is testing if the diabetes medication Canagliflozin can help protect kidney function in adults with Type 2 diabetes and early signs of kidney disease.

  Recruiting Phase 4 University of Michigan · Ann Arbor, Michigan · NCT06291155

• Long-term follow-up for patients who received REACT injections for kidney disease

  This study is looking at how safe and effective REACT injections are for people with chronic kidney disease over a five-year period.

  Recruiting Prokidney · Meridian, Idaho · NCT05918523

• New methods for diagnosing and treating type 2 diabetes nephropathy

  This study is testing new ways to diagnose and treat kidney problems in people with type 2 diabetes by using advanced tools and combining different medical approaches.

  Recruiting Chinese PLA General Hospital · Beijing · NCT05888909

• Effects of Semaglutide on Kidney Function in Type 1 Diabetes

  This study is testing if a medication called semaglutide can improve kidney function in adults with type 1 diabetes over 26 weeks.

  Recruiting at 4 sites Phase 2 University of Washington · Aurora, Colorado and 3 other locations · NCT05822609

• NAD supplementation for improving kidney health in diabetes

  This study is testing if taking a supplement called NMN can help improve kidney health in older adults with type 2 diabetes by lowering a specific marker in their urine.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT05759468

• Implementing diabetes treatment guidelines by primary care physicians in the community

  This study is testing whether following new diabetes treatment guidelines can help older adults with diabetes avoid serious heart and kidney problems compared to regular care.

  Recruiting at 13 sites Shanghai Zhongshan Hospital · Suzhou, Jaingsu and 12 other locations · NCT05349955

• Effects of Metformin and Automated Insulin Delivery on Youth with Type 1 Diabetes

  This study is testing if adding metformin and an automated insulin delivery system can help young people with type 1 diabetes improve their kidney and heart health.

  Recruiting Phase 1 Seattle Children's Hospital · Aurora, Colorado and 1 other locations · NCT05065372

• Understanding how puberty affects kidney health in youth with diabetes

  This study looks at how puberty affects kidney health in teenagers with type 2 diabetes and obesity to see if the changes during this time can harm their kidneys.

  Recruiting at 2 sites Seattle Children's Hospital · Aurora, Colorado and 1 other locations · NCT05008276

• Understanding Diabetic Kidney Disease in Patients with Type 2 Diabetes

  This study is trying to understand how kidney disease affects people with Type 2 diabetes and macroalbuminuria by looking at their kidney samples and other health markers over 20 years to improve treatment options.

  Recruiting at 13 sites Herlev Hospital · Skejby, Aarhus and 12 other locations · NCT04916132

• Assessing the impact of KidneyIntelX on managing chronic kidney disease in diabetes patients

  This study tests if the KidneyIntelX tool can help doctors better manage kidney health in people with Type 2 diabetes and chronic kidney disease.

  Recruiting Renalytix AI, Inc. · New York, New York · NCT04802395

• Study on the relationship between clinical features and kidney pathology in type 2 diabetes

  This study is trying to see how the symptoms of kidney problems in people with type 2 diabetes differ from those with other kidney diseases to help improve treatment and understanding of diabetic kidney disease.

  Recruiting Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT03865914

• Identifying imaging biomarkers for diabetic kidney disease

  This study is trying to find new ways to use MRI and ultrasound images to better understand and predict kidney problems in people with diabetes.

  Recruiting at 2 sites University of Leeds · Turku and 6 other locations · NCT03716401

NIH-funded research (39)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• siRNA nanoparticle treatment to stop diabetic kidney damage

  A new nanoparticle-delivered gene-silencing treatment aims to lower kidney inflammation in people with diabetes to help protect their kidneys.

  NIH research Georgia Institute of Technology · Atlanta, United States · NIH-11501229

• LRG1’s role in diabetic kidney disease and kidney fibrosis

  A study examines how a specific protein, LRG1, influences kidney disease related to diabetes and its scarring, with the aim of finding targeted ways to slow or prevent damage.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11466076

• Genetic discovery for diabetic kidney disease in adults

  A scientist team is studying the genes that influence diabetic kidney disease in adults to better understand why some people develop it.

  NIH research Broad Institute, INC. · Cambridge, United States · NIH-11399693

• Non-canonical NF-kB and inflammation in diabetic kidney disease

  A study to understand how a specific inflammatory pathway worsens kidney disease in adults with type 2 diabetes and how it might be treated.

  NIH research University of Hawaii at Manoa · Honolulu, United States · NIH-11372089

• Epidermal microfluidic screen to detect diabetic kidney disease

  A new skin-based microfluidic test platform may help identify kidney complications in people with diabetes using real-time biomarkers from sweat and glucose data.

  NIH research University of Hawaii at Manoa · Honolulu, United States · NIH-11372084

• PFAS exposure and kidney disease risk in teens with type 2 diabetes

  Aging and kidney health study in youths with type 2 diabetes to see how a common chemical (PFAS) affects kidney risk and how to prevent or treat it.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11370697

• GSK3beta’s role in diabetic kidney disease and protecting kidney cells

  This grant looks at how a molecule called GSK3beta affects kidney damage in people with diabetes and whether targeting it can protect kidney cells.

  NIH research University of Toledo Health Sci Campus · Toledo, United States · NIH-11361697

• New inflammation pathway in diabetic kidney disease

  This project explores how inflammation in the kidney of people with diabetes may be reduced by targeting a key cell that produces inflammatory signals.

  NIH research University of North Texas Hlth Sci Ctr · Fort Worth, United States · NIH-11361566

• How kidney glucose transporters affect early diabetic kidney changes

  This project looks at how two kidney glucose transporters (SGLT1 and SGLT2) change kidney filtering in people with diabetes.

  NIH research Boston Medical Center · Boston, United States · NIH-11307108

• How kidney filter cells and nearby tubule cells communicate in diabetic kidney disease

  This project looks at whether signals from podocytes can protect proximal tubule cells and slow kidney damage in people with diabetic kidney disease.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11302661

• Genetic causes of diabetic kidney disease

  This research looks at how genetic differences, especially in the Xor gene, change kidney damage risk in people with diabetes so new treatments can be developed.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11295460

• How fat-handling immune cells affect kidneys in type 2 diabetes

  This project tests whether changing how certain immune cells that store and clear fats work can help protect people with type 2 diabetes from worsening kidney damage.

  NIH research University of Washington · Seattle, United States · NIH-11293484

• RNA splicing changes in kidney tubules and diabetic kidney disease

  This project aims to understand how changes in RNA splicing inside kidney tubule cells during diabetes may cause kidney damage and point to new treatments.

  NIH research Washington University · Saint Louis, United States · NIH-11263698

• CH25H and 25‑hydroxycholesterol as potential protectors of diabetic kidneys

  This work looks at whether a cholesterol-processing enzyme (CH25H) and its product 25‑HC protect the tiny blood vessels in kidneys damaged by diabetes.

  NIH research James J Peters VA Medical Center · Bronx, United States · NIH-11247597

• Understanding how PFAS chemicals affect kidney disease in young people with Type 2 diabetes

  This project looks at how common chemicals called PFAS might contribute to kidney problems in young people with Type 2 diabetes.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11190901

• Understanding cell damage in chronic and diabetic kidney disease

  This research explores new ways that cells get damaged in chronic and diabetic kidney disease, hoping to find better ways to protect your kidneys.

  NIH research Lsu Pennington Biomedical Research Ctr · Baton Rouge, United States · NIH-11137671

• Understanding a protein in diabetic kidney disease

  This research aims to understand how a specific protein called GSK3beta contributes to diabetic kidney disease, hoping to find new ways to protect the kidneys.

  NIH research University of Toledo Health Sci Campus · Toledo, United States · NIH-11128712

• Finding genes linked to diabetes-related kidney damage

  This project searches for gene changes that raise or lower the chance of kidney damage in people with type 1 and type 2 diabetes.

  NIH research Broad Institute, INC. · Cambridge, United States · NIH-11123254

• Protecting kidney cells in diabetic kidney disease using signaling molecules

  This study is looking at how certain natural substances can help protect kidney cells from damage caused by diabetes, with the hope of finding new treatments that could improve kidney health for people with diabetic kidney disease.

  NIH research Durham VA Medical Center · Durham, United States · NIH-11098485

• Investigating the impact of PFAS on kidney disease in young people with type 2 diabetes

  This study is looking at how certain chemicals called PFAS might affect kidney health in young people with type 2 diabetes, helping to find out who might be at risk for kidney problems and how these chemicals could be involved.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11075249

• Understanding the genetic factors behind Diabetic Kidney Disease

  This study is looking at how genes might play a role in Diabetic Kidney Disease, which can lead to kidney failure, by using mice to find out which genes affect kidney health in diabetes, with the hope of discovering new treatments for people with this condition.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11066521

• Understanding how kidney feedback mechanisms affect diabetes treatment

  This study looks at how diabetes affects kidney function and how certain treatments might help protect your kidneys by managing sugar levels in your body.

  NIH research Boston Medical Center · Boston, United States · NIH-11055435

• Investigating the protective role of a cholesterol metabolite in diabetic kidney disease.

  This study is looking at how a specific protein and its byproduct might impact kidney health in people with diabetic kidney disease, hoping to find new ways to help improve kidney function for those affected.

  NIH research James J Peters VA Medical Center · Bronx, United States · NIH-11052023

• Investigating how changes in kidney cell processes affect diabetic kidney disease progression

  This study is looking at how changes in kidney cell genes affect diabetic kidney disease and how a specific type of medication might help improve this condition.

  NIH research Washington University · Saint Louis, United States · NIH-11048691

• Understanding how autophagy affects kidney disease in diabetes

  This study is looking at how a process that helps keep kidneys healthy might affect people with diabetes who have kidney problems, with the hope of finding better ways to diagnose and treat their condition.

  NIH research University of Washington · Seattle, United States · NIH-11031987

• How inflammatory cells activate a system that affects kidney disease in diabetes

  This study is looking at how certain immune cells in the kidneys might be affecting a system that can worsen kidney problems in people with diabetes, and it aims to find new ways to help treat these issues.

  NIH research Wayne State University · Detroit, United States · NIH-11013359

• Investigating how GPR56 affects kidney cell injury in early diabetes-related kidney disease

  This study is looking at how a specific protein called GPR56 affects kidney cells during the early stages of diabetic kidney disease, with the hope of finding new ways to help people with this condition.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11013319

• Investigating how PFAS exposure affects kidney health in youth with type 2 diabetes

  This study is looking at how certain harmful chemicals called PFAS affect kidney health in young people with type 2 diabetes, especially in Latinx and African American youth, to find ways to prevent and treat kidney problems.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-10942017

• Investigating how certain molecules affect kidney disease in diabetes

  This study is looking at how certain molecules in the body might affect kidney health, especially for people with chronic or diabetic kidney disease, to find new ways to help keep kidneys working better.

  NIH research Lsu Pennington Biomedical Research Ctr · Baton Rouge, United States · NIH-10906386

• Using NAD supplements to treat kidney disease in diabetes patients

  This study is looking at whether taking a supplement called NMN can help improve kidney health and lower signs of damage in people with diabetic kidney disease.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10906074

• Investigating the role of a specific protein in kidney disease related to diabetes

  This study is looking at how a protein called RARRES1 impacts kidney health in people with diabetic kidney disease, and it hopes to find new ways to help manage this condition by using tissue samples from patients and experiments with mice.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10883725

• Improving care for patients with diabetic kidney disease during hospital transitions

  This study is looking to help people with diabetic kidney disease by making sure they get the right medications and support when they leave the hospital, especially for those who might need extra help, so they can stay healthier at home.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-10869841

• New treatments to stop kidney damage from diabetes

  This study is looking at new ways to protect your kidneys from damage caused by diabetes by using tiny particles to deliver special treatments that can help reduce inflammation, and they hope this will lead to better options for people with diabetic kidney disease.

  NIH research Massachusetts Institute of Technology · Cambridge, United States · NIH-10865338

• Using MRI to measure kidney oxygen levels in early diabetic kidney disease

  This study is looking at a new way to check how well your kidneys are working using MRI technology, which could help catch problems early for people with diabetes before serious damage happens.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10833573

• Exploring how complement proteins affect kidney disease in diabetes

  This study is looking at how certain proteins in your urine might help us understand and track kidney problems in people with diabetes, with the hope of finding new ways to protect your kidneys from damage.

  NIH research Joslin Diabetes Center · Boston, United States · NIH-10809603

• Investigating the role of APOC3 in heart and kidney diseases related to diabetes

  This study is looking at how a protein called APOC3 affects heart and kidney problems in people with diabetes, and it hopes to find out if blocking this protein can help prevent kidney disease, especially in those with both diabetes and kidney issues, which might raise the risk of heart disease.

  NIH research University of Washington · Seattle, United States · NIH-10774240

• Understanding protective factors in kidney disease for type 1 diabetes patients

  This study is looking at how certain cells in the skin might help protect people with type 1 diabetes from kidney problems, and it hopes to find new ways to improve treatment for those at risk of diabetic kidney disease.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-10753046

• Understanding bone health in people with type 1 diabetes and kidney disease

  This study is looking at how type 1 diabetes and kidney problems can affect bone health and increase the risk of fractures, so we can find better ways to help people with diabetes keep their bones strong and healthy.

  NIH research Northern California Institute/res/edu · San Francisco, United States · NIH-10684140

• Helping African Americans with diabetes and kidney disease navigate basic needs.

  This study is all about helping African Americans with diabetic kidney disease, especially those who are struggling financially, by providing support and education to make it easier for them to manage their health and improve their well-being.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-10676228

Related topics

Quick answers

How many Diabetic Kidney Disease clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (8 trials), China (5 trials), Canada (2 trials), France (2 trials), Denmark (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 3, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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