Protecting kidney cells in diabetic kidney disease using signaling molecules
Promoting podocyte protective cGMP signaling in diabetic kidney disease
['FUNDING_OTHER'] · DURHAM VA MEDICAL CENTER · NIH-11098485
This study is looking at how certain natural substances can help protect kidney cells from damage caused by diabetes, with the hope of finding new treatments that could improve kidney health for people with diabetic kidney disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DURHAM VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11098485 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how specific signaling molecules, known as natriuretic peptides, can protect kidney cells called podocytes from damage in diabetic kidney disease. The study investigates how these peptides stimulate the production of a protective signaling molecule called cGMP in podocytes, which is crucial for maintaining kidney health. By blocking a receptor that degrades these peptides, the research aims to enhance their protective effects and reduce kidney injury. Patients may benefit from insights that could lead to new treatments for diabetic nephropathy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with diabetic kidney disease, particularly those experiencing albuminuria.
Not a fit: Patients without diabetic kidney disease or those with other unrelated kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that protect kidney function in patients with diabetic kidney disease.
How similar studies have performed: Other research has shown promising results using similar approaches to enhance kidney protection, indicating potential for success in this area.
Where this research is happening
DURHAM, UNITED STATES
- DURHAM VA MEDICAL CENTER — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SPURNEY, ROBERT — DURHAM VA MEDICAL CENTER
- Study coordinator: SPURNEY, ROBERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.