Understanding how PFAS chemicals affect kidney disease in young people with Type 2 diabetes
Official title: PFAS Exposure and Diabetic Kidney Disease in Youth with Type 2 Diabetes: A Multi-Omic Approach for Prevention and Treatment
Funded at University of Southern California · NIH-11190901 · Data updated 2026-11-12
This project looks at how common chemicals called PFAS might contribute to kidney problems in young people with Type 2 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | September 10, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $693,571 |
| NIH project number | 5R01DK140831-02 |
| Project ID | NIH-11190901 on NIH RePORTER |
Who could benefit from this research
✓Could help
This project focuses on understanding existing data from Latinx and African American youth aged 12-20 who have Type 2 diabetes and are at risk for or have developed diabetic kidney disease.
✕Less likely to help
Patients who do not have Type 2 diabetes or are outside the specified age range would not directly benefit from this specific data analysis.
What this research studies
Many young people with Type 2 diabetes develop kidney disease, especially Latinx and African American youth, and current treatments are limited. This project explores whether exposure to PFAS, a group of widespread artificial chemicals, increases the risk of kidney damage in these young individuals. Researchers believe that specific transporters in the kidney, called OATs, might play a role by reabsorbing PFAS and concentrating them in kidney cells. By studying existing health information from two groups of young people with Type 2 diabetes, this work aims to understand if reducing the reabsorption of these chemicals could help prevent kidney disease.
Why it matters
Potential benefit: If successful, this work could identify new ways to prevent and treat diabetic kidney disease in young people by targeting PFAS exposure or its effects on the kidneys.
How similar studies have gone: This is described as a first-of-its-kind study examining this specific hypothesis, though preliminary data links PFAS to kidney injury in youth with Type 2 diabetes.
Where this research is happening
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University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Goodrich, Jesse Allen — University of Southern California
- Study coordinator: Goodrich, Jesse Allen
Related research
Other NIH-funded projects on the same topics.
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PFAS exposure and kidney disease risk in teens with type 2 diabetes
Aging and kidney health study in youths with type 2 diabetes to see how a common chemical (PFAS) affects kidney risk and how to prevent or treat it.
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Investigating the impact of PFAS on kidney disease in young people with type 2 diabetes
This study is looking at how certain chemicals called PFAS might affect kidney health in young people with type 2 diabetes, helping to find out who might be at risk for kidney problems and how these chemicals could be involved.
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Investigating how PFAS exposure affects kidney health in youth with type 2 diabetes
This study is looking at how certain harmful chemicals called PFAS affect kidney health in young people with type 2 diabetes, especially in Latinx and African American youth, to find ways to prevent and treat kidney problems.
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Rapid, multi-drug initiation for people with CKD and type 2 diabetes
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Improving heart- and kidney-protective treatment for people with type 2 diabetes and chronic kidney disease
This project will help people with type 2 diabetes and chronic kidney disease get proven medicines that protect the heart and kidneys but are often missed.
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Improving heart and kidney treatment for patients with diabetes
This study is looking into why people with type 2 diabetes and chronic kidney disease aren't getting the heart-protecting treatments they need, and it aims to find ways to make sure these important medications are prescribed more often.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.