Investigating how changes in kidney cell processes affect diabetic kidney disease progression
Official title: Proximal Tubule Alternative Splicing and Progression of Diabetic Kidney Disease
Funded at Washington University · NIH-11048691 · Data updated 2026-11-12
This study is looking at how changes in kidney cell genes affect diabetic kidney disease and how a specific type of medication might help improve this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | February 1, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $531,999 |
| NIH project number | 1R01DK136663-01A1 |
| Project ID | NIH-11048691 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with diabetic kidney disease, particularly those who may benefit from new therapeutic approaches.
✕Less likely to help
Patients without diabetes or those who do not have kidney disease may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of alternative splicing in kidney cells and how it contributes to the progression of diabetic kidney disease (DKD). The team will utilize advanced techniques, including single nucleus RNA sequencing, to analyze kidney cells from a mouse model of DKD and assess the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on these processes. By examining how these treatments influence gene expression and inflammation in kidney cells, the research aims to uncover new therapeutic targets for DKD.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diabetic kidney disease, potentially slowing its progression and reducing the risk of end-stage kidney disease.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of diabetic kidney disease, but this specific approach focusing on alternative splicing is relatively novel.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Humphreys, Benjamin D. — Washington University
- Study coordinator: Humphreys, Benjamin D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.