Investigating how changes in kidney cell processes affect diabetic kidney disease progression
Proximal Tubule Alternative Splicing and Progression of Diabetic Kidney Disease
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-11048691
This study is looking at how changes in kidney cell genes affect diabetic kidney disease and how a specific type of medication might help improve this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11048691 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of alternative splicing in kidney cells and how it contributes to the progression of diabetic kidney disease (DKD). The team will utilize advanced techniques, including single nucleus RNA sequencing, to analyze kidney cells from a mouse model of DKD and assess the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on these processes. By examining how these treatments influence gene expression and inflammation in kidney cells, the research aims to uncover new therapeutic targets for DKD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with diabetic kidney disease, particularly those who may benefit from new therapeutic approaches.
Not a fit: Patients without diabetes or those who do not have kidney disease may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diabetic kidney disease, potentially slowing its progression and reducing the risk of end-stage kidney disease.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of diabetic kidney disease, but this specific approach focusing on alternative splicing is relatively novel.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUMPHREYS, BENJAMIN D. — WASHINGTON UNIVERSITY
- Study coordinator: HUMPHREYS, BENJAMIN D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.