Understanding how autophagy affects kidney disease in diabetes
Official title: Autophagy in Diabetic Kidney Disease
Funded at University of Washington · NIH-11031987 · Data updated 2026-11-12
This study is looking at how a process that helps keep kidneys healthy might affect people with diabetes who have kidney problems, with the hope of finding better ways to diagnose and treat their condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | May 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $187,916 |
| NIH project number | 5K23DK135789-03 |
| Project ID | NIH-11031987 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with diabetes who are experiencing or at risk for diabetic kidney disease.
✕Less likely to help
Patients without diabetes or those with kidney disease unrelated to diabetes may not benefit from this research.
What this research studies
This research investigates the role of autophagy, a cellular process that helps maintain kidney health, in diabetic kidney disease (DKD). By examining kidney samples and clinical data from patients with diabetes, the study aims to uncover the molecular mechanisms that contribute to the variability in DKD symptoms and progression. The goal is to develop personalized diagnostic and treatment strategies based on these findings, which could lead to better management of kidney health in diabetic patients.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for patients with diabetic kidney disease.
How similar studies have gone: Previous research has shown promising results in understanding autophagy in experimental models of diabetes, but this approach in human diabetic kidney disease is relatively novel.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Limonte, Christine — University of Washington
- Study coordinator: Limonte, Christine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.