Understanding cell damage in chronic and diabetic kidney disease
Official title: Novel redox mechanisms of oxygenated phospholipids in chronic and diabetic kidney disease
Funded at Lsu Pennington Biomedical Research Ctr · NIH-11137671 · Data updated 2026-11-12
This research explores new ways that cells get damaged in chronic and diabetic kidney disease, hoping to find better ways to protect your kidneys.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Pennington Biomedical Research Ctr NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | August 15, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $299,843 |
| NIH project number | 5R01DK137472-03 |
| Project ID | NIH-11137671 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is for patients with chronic or diabetic kidney disease who are interested in understanding the basic science behind their condition and potential future treatments.
✕Less likely to help
Patients seeking immediate new treatments or direct clinical intervention will not find direct benefit from this basic science research.
What this research studies
For a long time, we've known that 'oxidative stress' plays a role in kidney disease, but this project looks beyond the usual suspects. We believe that specific fat molecules, called lipid peroxides, act as important signals that tell kidney cells to become unhealthy or even die. By understanding exactly which of these signals are involved and how they work, we hope to find new targets for treatments. This could help prevent the progression of kidney damage in people with chronic and diabetic kidney disease.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that specifically block harmful signals in kidney cells, potentially slowing or preventing the progression of chronic and diabetic kidney disease.
How similar studies have gone: While the general concept of lipid damage is known, this specific focus on identifying particular signaling molecules and their roles in kidney disease is a novel approach.
Where this research is happening
-
Lsu Pennington Biomedical Research Ctr
Baton Rouge, United States Active
Researchers
- Principal investigator: Stadler, Krisztian — Lsu Pennington Biomedical Research Ctr
- Study coordinator: Stadler, Krisztian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.