Understanding how kidney feedback mechanisms affect diabetes treatment
Official title: Significance of Tubuloglomerular Feedback in SGLT1 and SGLT2 Inhibition in Diabetic Kidney Disease
Funded at Boston Medical Center · NIH-11055435 · Data updated 2026-11-12
This study looks at how diabetes affects kidney function and how certain treatments might help protect your kidneys by managing sugar levels in your body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $372,536 |
| NIH project number | 5R01DK134616-04 |
| Project ID | NIH-11055435 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with diabetes who are at risk of developing diabetic kidney disease.
✕Less likely to help
Patients without diabetes or those with advanced kidney disease may not benefit from this research.
What this research studies
This research investigates how the kidneys respond to changes in glucose levels in diabetic patients, particularly focusing on the role of tubuloglomerular feedback (TGF) in regulating kidney function. It explores how sodium-glucose cotransporters (SGLT1 and SGLT2) influence glomerular filtration rate (GFR) and how their inhibition may protect against diabetic kidney disease. By examining these mechanisms, the research aims to identify new therapeutic strategies that could improve kidney health in individuals with diabetes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that protect kidney function in diabetic patients.
How similar studies have gone: Previous research has shown promising results in understanding kidney feedback mechanisms in diabetes, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Boston Medical Center
Boston, United States Active
Researchers
- Principal investigator: Zhang, Jie — Boston Medical Center
- Study coordinator: Zhang, Jie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.