Understanding how kidney feedback mechanisms affect diabetes treatment
Significance of Tubuloglomerular Feedback in SGLT1 and SGLT2 Inhibition in Diabetic Kidney Disease
['FUNDING_R01'] · BOSTON MEDICAL CENTER · NIH-11055435
This study looks at how diabetes affects kidney function and how certain treatments might help protect your kidneys by managing sugar levels in your body.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11055435 on ClinicalTrials.gov |
What this research studies
This research investigates how the kidneys respond to changes in glucose levels in diabetic patients, particularly focusing on the role of tubuloglomerular feedback (TGF) in regulating kidney function. It explores how sodium-glucose cotransporters (SGLT1 and SGLT2) influence glomerular filtration rate (GFR) and how their inhibition may protect against diabetic kidney disease. By examining these mechanisms, the research aims to identify new therapeutic strategies that could improve kidney health in individuals with diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with diabetes who are at risk of developing diabetic kidney disease.
Not a fit: Patients without diabetes or those with advanced kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that protect kidney function in diabetic patients.
How similar studies have performed: Previous research has shown promising results in understanding kidney feedback mechanisms in diabetes, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, JIE — BOSTON MEDICAL CENTER
- Study coordinator: ZHANG, JIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.