Understanding protective factors in kidney disease for type 1 diabetes patients

Who could benefit from this research

What this research studies

This research investigates the protective mechanisms that may help prevent diabetic kidney disease (DKD) in patients with type 1 diabetes. By examining skin fibroblasts from individuals with and without DKD, the study aims to identify unique cellular behaviors and gene expression patterns that contribute to protection against kidney damage. The researchers will analyze how these protective pathways are activated in response to high glucose levels, which can cause DNA damage. The goal is to uncover insights that could lead to improved treatments and outcomes for patients at risk of DKD.

Why it matters

Where this research is happening

• Cleveland Clinic Lerner Com-Cwru
  Cleveland, United States Active

Researchers

• Principal investigator: Caramori, Maria Luiza a — Cleveland Clinic Lerner Com-Cwru
• Study coordinator: Caramori, Maria Luiza a

Related research

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.