Understanding protective factors in kidney disease for type 1 diabetes patients
Protective factors in diabetic kidney disease in patients with type 1 diabetes
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-10753046
This study is looking at how certain cells in the skin might help protect people with type 1 diabetes from kidney problems, and it hopes to find new ways to improve treatment for those at risk of diabetic kidney disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10753046 on ClinicalTrials.gov |
What this research studies
This research investigates the protective mechanisms that may help prevent diabetic kidney disease (DKD) in patients with type 1 diabetes. By examining skin fibroblasts from individuals with and without DKD, the study aims to identify unique cellular behaviors and gene expression patterns that contribute to protection against kidney damage. The researchers will analyze how these protective pathways are activated in response to high glucose levels, which can cause DNA damage. The goal is to uncover insights that could lead to improved treatments and outcomes for patients at risk of DKD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 1 diabetes, particularly those who have not yet developed diabetic kidney disease.
Not a fit: Patients with type 2 diabetes or those who already have advanced diabetic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing kidney disease in patients with type 1 diabetes.
How similar studies have performed: Previous research has indicated potential protective mechanisms in diabetic kidney disease, suggesting that this approach may yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARAMORI, MARIA LUIZA A — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: CARAMORI, MARIA LUIZA A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Injury