Understanding a protein in diabetic kidney disease
Role of GSK3beta in diabetic kidney disease
['FUNDING_R01'] · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · NIH-11128712
This research aims to understand how a specific protein called GSK3beta contributes to diabetic kidney disease, hoping to find new ways to protect the kidneys.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS (nih funded) |
| Locations | 1 site (TOLEDO, UNITED STATES) |
| Trial ID | NIH-11128712 on ClinicalTrials.gov |
What this research studies
Diabetic kidney disease is a serious condition that often leads to kidney failure, and we currently lack effective treatments. This project explores how problems with insulin signaling in kidney cells, specifically podocytes, play a role in this disease. Researchers are focusing on a protein called GSK3beta, which appears to be overactive in the kidneys of people with diabetic kidney disease. By studying how GSK3beta affects kidney cell damage and aging, we hope to uncover new targets for future therapies.
Who could benefit from this research
Good fit: Patients with diabetic kidney disease could potentially benefit from future treatments developed based on this foundational understanding.
Not a fit: Patients without diabetic kidney disease would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could identify a new target for medications that could slow or stop the progression of diabetic kidney disease.
How similar studies have performed: The role of GSK3beta in diabetic kidney disease is currently debated, with limited and sometimes conflicting findings from previous studies.
Where this research is happening
TOLEDO, UNITED STATES
- UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS — TOLEDO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GONG, RUJUN — UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
- Study coordinator: GONG, RUJUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.