Investigating how certain molecules affect kidney disease in diabetes
Novel redox mechanisms of oxygenated phospholipids in chronic and diabetic kidney disease
['FUNDING_R01'] · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · NIH-10906386
This study is looking at how certain molecules in the body might affect kidney health, especially for people with chronic or diabetic kidney disease, to find new ways to help keep kidneys working better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LSU PENNINGTON BIOMEDICAL RESEARCH CTR (nih funded) |
| Locations | 1 site (BATON ROUGE, UNITED STATES) |
| Trial ID | NIH-10906386 on ClinicalTrials.gov |
What this research studies
This research explores the role of specific oxidized phospholipids in the development of chronic and diabetic kidney disease. It aims to understand how these molecules, which are less reactive than superoxide, can signal stress in kidney cells and contribute to cell dysfunction. By focusing on proximal tubular epithelial cells, the study seeks to identify how changes in these molecules can influence kidney health and potentially lead to new therapeutic strategies. The approach involves detailed biochemical analysis to uncover the mechanisms behind these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic or diabetic kidney disease.
Not a fit: Patients with acute kidney injury or those without any form of kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or prevent kidney disease in diabetic patients.
How similar studies have performed: While the role of oxidative stress in kidney disease has been studied, the specific focus on oxidized phospholipids as metabolic signals is a novel approach.
Where this research is happening
BATON ROUGE, UNITED STATES
- LSU PENNINGTON BIOMEDICAL RESEARCH CTR — BATON ROUGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STADLER, KRISZTIAN — LSU PENNINGTON BIOMEDICAL RESEARCH CTR
- Study coordinator: STADLER, KRISZTIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.