Investigating how certain molecules affect kidney disease in diabetes
Official title: Novel redox mechanisms of oxygenated phospholipids in chronic and diabetic kidney disease
Funded at Lsu Pennington Biomedical Research Ctr · NIH-10906386 · Data updated 2026-11-12
This study is looking at how certain molecules in the body might affect kidney health, especially for people with chronic or diabetic kidney disease, to find new ways to help keep kidneys working better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Pennington Biomedical Research Ctr NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | August 15, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $287,849 |
| NIH project number | 5R01DK137472-02 |
| Project ID | NIH-10906386 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic or diabetic kidney disease.
✕Less likely to help
Patients with acute kidney injury or those without any form of kidney disease may not benefit from this research.
What this research studies
This research explores the role of specific oxidized phospholipids in the development of chronic and diabetic kidney disease. It aims to understand how these molecules, which are less reactive than superoxide, can signal stress in kidney cells and contribute to cell dysfunction. By focusing on proximal tubular epithelial cells, the study seeks to identify how changes in these molecules can influence kidney health and potentially lead to new therapeutic strategies. The approach involves detailed biochemical analysis to uncover the mechanisms behind these processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or prevent kidney disease in diabetic patients.
How similar studies have gone: While the role of oxidative stress in kidney disease has been studied, the specific focus on oxidized phospholipids as metabolic signals is a novel approach.
Where this research is happening
-
Lsu Pennington Biomedical Research Ctr
Baton Rouge, United States Active
Researchers
- Principal investigator: Stadler, Krisztian — Lsu Pennington Biomedical Research Ctr
- Study coordinator: Stadler, Krisztian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.